Notova S.V., Kiyaeva E.V., Ermakova N.V., Kazakova T.V., Marshinskaya O.V.
CORRELATION OF PSYCHOLOGICAL CHARACTERISTICS WITH PARAMETERS OF THE METABOLISM OF DISABLED ATHLETES ^{[№ 9 ' 2017]}
Сurrently the Paralympic games are the largest event of world sports, which increases the level of competition between participants. In the preparation of athletes to the games should pay increased attention to their psychological state and a number of indicators of metabolism of the body. Using this data and taking into account their relationship can increase the level of sporting achievements and preserve the health of Paralympic athletes. Conducted psychological research in General had satisfactory results. It was established the absence of significant negative emotions in connection with the peculiarities of physical and psycho-emotional stresses sledge hockey team. This may indicate a sufficient level of adaptation of athletes to training activities. The study of the elemental composition of hair showed that for the majority of the surveyed athletes was characterized by an excess of P, Na, K, Zn, and deficiency of Co, Cr, Ca and Se. In biochemical indicators of blood revealed elevated values of glucose, ALT, direct bilirubin and alkaline phosphatase from 40, 33, 47 and 47 % of patients, respectively. In the course of correlation analysis the highest correlation was observed between the studied psychological indicators and the level of Be, Mg, Se, Si, Al and CA in hair. Most of the indicators of the mental state was significantly correlated with the level of pancreatic amylase, γ-GT, AST, total protein and blood glucose. The study shows the link of the elemental composition of hair and biochemical indicators of psychological characteristics. Despite the fact that the psychological status of the athletes was normal, the indicators of the elemental balance and biochemical profile, in contrast, had deviations, which subsequently can lead to deficient growth and manifestations of neuropsychiatric diseases. Therefore, a questionnaire analysis of psychological status cannot give a full picture of the condition of the athletes, indicating the need for a parallel analysis of the indices of protein, carbohydrate, mineral and lipid metabolism and their timely correction.

Notova S.V., Slobodskov A.A., Bokov D.A., Sizova E.A.
SRC GENE EXPRESSION IN CHANGING PLACENTAL TISSUESAFTER EXPOSURE TO COPPER NANOPARTICLES ^{[№ 12 ' 2016]}
The SRC gene is a protooncogene with vague regulatory functions. Protein products of its expression are tyrosinkinases that modulate membrane receptors to cytokines involved in cell proliferation and differentiation. Placental insufficiency and placental immaturity are characterized by complicated pathogenesis, so morphogenetic and regulatory aspects of their development are not clearly defined. In addition, inevitable usage of nanostructured substances for the purpose of medical diagnosis and treatment is presently evident. There were shown toxigenic features of nanoparticles for placental tissues leading to intolerable decline in surface area of the chorion and fetal-placental metabolic rate. The aim of the research is to establish connections between c-src gene expression and structural processes of chorial remodeling after damage. The study shows the main mechanisms of placental adaptation after exposure to copper nanoparticles (dose 1.0 mg/kg) administered to pregnant Wistar rats throughout the gestation period. The first mechanism consists in the increase in the proportion of intermediate villi and their processes, the second one is the increase in volume of syncytial knots. As a result, new formation of structures is observed, including terminal villi. The src gene expression was detected in epithelial cells of syncytial knots, as well as on separate epithelial sites of intermediate and terminal villi (induced epithelium). SRC gene is also actively expressed in fibroblasts of fetal stroma. Decidua and peripheral portion of trophoblast in spongy zone do not contain signs of SRC gene activity. Thus, there was established that SRC gene plays a regulatory role increasing processes of chorionic villi growth in placenta after exposure to copper nanoparticles and consequent damage.

Borisyuk S.V., Notova S.V., Kvan O.V.
THE ELEMENTAL COMPOSITION OF BONE PREGNANT FEMALE RATS ON THE BACKGROUND OF DIFFERENT LEVELS OF CONSUMPTION OF DIETARY FIBER IN THE DIET ^{[№ 5 ' 2016]}
The paper presents the results of a study of the elemental composition of bone pregnant female rats who were on a diet with excess and deficient intake of dietary fiber before and during pregnancy (6 weeks). The basis of power was a semisynthetic casein diet that ensures adequate intake of protein, fat and carbohydrates, dietary fiber (2 g microcellulose), vitamins and salts. Deficiency of dietary fiber was modeled by excluding from the diet microcellulose, excess diet — by increasing the level of consumption microcellulose to 4 g/day. Modeling fiber deficiency in the diet of treated animals resulted primarily in a reduction of macroelements such as calcium and phosphorus. Among the essential trace elements mentioned only a change in the content of selenium — lower values as when scarce, and in excess diet. No significant changes in the content of toxic elements in the experimental groups were not observed.

Borisyuk S.V., Notova S.V., Kvan O.V., Rusakova E.A.
FEATURES OF THE ELEMENTAL COMPOSITION OF THE LIVER OF PREGNANT FEMALE RATS ON THE BACKGROUND OF DIFFERENT DIETARY FIBER ^{[№ 4 ' 2016]}
High consumption of food fibers can break mineral balance in an organism. The exception of a diet of food fibers promotes higher content in muscular tissue of copper, iron, iodine, manganese, silicon and arsenic. In this regard interest causes element structure of a liver against various level of consumption of food fibers during pregnancy. Researches of element structure of a liver of pregnant females of the rats who are on a diet with various level of consumption of food fibers before approach and during pregnancy (only 6 weeks) are conducted. The basis of power was a semisynthetic casein diet that ensures adequate intake of protein, fat and carbohydrates, dietary fiber (2 g microcellulose), vitamins and salts. Deficiency of dietary fiber was modeled by excluding from the diet microcellulose, excess diet — by increasing the level of consumption microcellulose to 4 g/day. Comparing the elemental composition of the liver of female rats revealed that simulation deficiency of dietary fibers in the diet leads mainly to a decrease in the content of chemical elements except manganese. The most sensitive to the deficit dietary fibers appeared level of such elements as iodine, nickel, and silicon. Excessive intake of dietary fiber associated with a reduced content of chromium, iodine, nickel, arsenic, silicon, and toxic chemical elements such as mercury and tin, which is probably due to their absorption characteristics. Changes in dietary fiber intake had no effect on the level of most of the chemical elements deposited in the liver, such as iron, potassium, copper, zinc and selenium. These data support an important role in liver hemostasis these elements.

Notova S.V., Kiyaeva E.V., Alidzhanova I.E., Cheremushnikova I.I., Bibartseva E.V.
PSYCHOPHYSIOLOGICAL AND METABOLIC ASPECTSOF ADAPTATIONAND DISADAPTATIONOF STUDENTS ^{[№ 13 ' 2015]}
Stress factors are the causes of emotional stress, reduced functional reserves of the organism, stress leads to increased morbidity and mortality. That's why studying of the mechanisms of adaptation and disadaptation of person has special importance. The article presents the results of long-term studies of the psycho-physiological and metabolic parameters'changes during the adaptation to various environmental conditions. The peculiarities of physical development, lifestyle, eating habits, bad habits, as well as cardio and metabolic parameters in students of different ethnic groups were investigated. Elemental portrait of young men with information about the features of the element status shows that most abnormalities are not related with ethnicity, but are related with the region of residence. At the same time, it was shown the influence of the person individual characteristics on the process of adaptation of students. Correlation analysis between psychological indices and the parameters of adaptation showed that the largest number of correlations between psychological characteristics and cardioindicators were in the group of Tatars. In addition, it is was shown that the functional hemispheric asymmetry of the brain affected on the body's ability to adaptation. Right hemisphere dominant young men hada higher rate of reaction according to the tests "assess attention", "noise immunity", "simple hand-eye reaction". Regardless of the type of functional hemispheric asymmetry, the young men had deficient of cobalt, selenium, an excess of lithium, iron and zinc, compared with the optimal interval centile. Thus, the adaptability of the organism depends on many factors, and defining factors are ethnic characteristics, the type of functional hemispheric asymmetry, lifestyle and environmental living conditions.

Notova S.V., Timasheva A.B., Lebedev S.V., Sizovа E.A.,Miroschnikov S.V.
ELEMENT STATUS AND BIOCHEMICAL COMPOSITION OF BLOOD LABORATORY ANIMALS WHEN ADMINISTERED INTRAMUSCULARLY ASPARGINATA AND COPPER NANOPARTICLES ^{[№ 12 ' 2013]}
The paper presents the results of a study of the element status and biochemical composition of the blood of laboratory animals when copper in various forms. It was revealed that the performance of mineral metabolism depend on the physical and chemical form of the metal. Since the introduction of copper aspartate accompanied by significant increase in concentration of Co, Cu, Ca, P, Sr against decrease I, Se, Pb. At the same time the introduction of copper nanoparticles increases the concentration of Cu, Ca, P, Al, Sr, against reduction Pb and I. when introduced into the body of copper in nanoform, biochemical blood indices have lower values than in a asparginata.

Miroshnikov S.V., Notova S.V., Kiyaeva E.V., Alidzhanova I.E., Slobodskov A.A.
FEATURES OF HAIR AND VARIOUS THYROID STRUCTURES ELEMENT COMPOSITION IN ENDEMIC IODINE DEFICIENCY REGION ^{[№ 10 ' 2013]}
The results of the study of the element composition of the hair and the various structures of the thyroid gland of women living in the Orenburg region are presented. It is established that in the pathogenesis of proliferation of thyroid cells leading to the formation of nodular thyroid pathology not only iodine is important. Cd, Sn, Ni, Zn and Cu participate in the disruption of expression of autocrine growth factors in the thyroid gland.

Notova S.V., Duskaeva A.H., Miroshnikov S.V.
EVALUATION OF INFLUENCE OF DIETARY STRESS ON PSYCHOPHYSIOLOGICAL AND METABOLIC INDICES ^{[№ 10 ' 2012]}
The article presents results assessment of physical development, behavior, and clinical-laboratory indicators of experimental animals the under influence fast preparation products in combination with water and carbonated drink. Observed adverse effects experienced diets at living mass of rats, reducing the horizontal and vertical motion activity, hematological indices of animals.

Miroshnikov S.V., Notova S.V., Kvan O.V.
THE FEATURES OF ADAPTABLE REACTIONS AT PERSONS WITH HIGH- AND LOWNORMAL LEVEL THYRITROPIC OF THE HORMONE, LIVING IN TERRITORY ENDEMOS ON THE CRAW ^{[№ 12 ' 2011]}
In work results of researches of features of adaptable reactions at persons with high lownormal level thyritropic a hormone (ТТH), living on territory endemos on a craw are presented. In the course of research of the analysis of variability of a rhythm of heart at persons with highnormal level ТТH it has been revealed, is established influence highnormal level ТТH on homeostatic parameters of an organism.

Cheremushnikova I.I., Notova S.V., Barysheva E.S., Davydova N.V., Grivko N.V., Smantser T.A.
PSYCHO-PHYSIOLOGICAL TESTING AS A METHOD FOR EVALUATING THE EFFECTIVENESS OF THE TRAINING OF STUDENTS ^{[№ 12 ' 2011]}
In article results of studying of typological features of psychomotor indicators of students, in the form of individual profiles with definition of their interrelation with personal characteristics of the person are presented. The Tepping-test is considered, how the tool of studying of psychophysiological features of educational activity of students, and a technique with application of tables "Shulte — Platonova", as an authentic method of definition of level of their working capacity.

Alidzhanova I.E., Notova S.V., Kiyaeva E.V.
THE INFLUENCE OF THE STRESS-FACTORS OF DIFFERENT NATURE ON THE ACCUMULATION OF CHEMICAL ELEMENTS IN BODIES OF LABORATORY ANIMALS ^{[№ 12 ' 2010]}
The authors studied the special features of the accumulation of chemical elements in bodies of laboratory animals under the action of the stress-factors of different nature (physical load, the scarcity of nutrients). They revealed the unbalance of the chemical elements against the background of intensive physical load in laboratory animals. In this case reduction in the concentration of all of the macro- and overwhelming majority of the essential elements against the background of the accumulation of some toxic elements in bodies of animal experimental groups was observed.

Cheremushnikova I.I., Vitun E.V., Petrosienko E.S., Notova S.V.
THE POSSIBILITIES OF THE LUSHER TEST (8- COLOR VERSION) IN DIAGNOSTICS OF THE CHARACTEROLOGICAL AND BEHAVIORAL SPECIAL FEATURES OF STUDENTS WITH DIFFERENT LEVEL OF PHYSICAL TRAINING ^{[№ 12 ' 2010]}
The authors revealed diagnostic signs of emotional disturbances with the inspection of students with the aid of the color procedure give the possibility of the thinner and more timely recognition of the specific criteria of emotional disorders. The color Lusher test can be used as the means of the estimation of emotional dynamics in students by the force of the small effect of habituation. Possessing the ability of penetration into the peace of experiences, color procedure can be used for the adjusting of personal- emotional contact between the student, the instructor, the psychologist in the conditions of higher school.

Petrosienko Е.S., Cheremushnikova I.I., Notova S.V., Biryukov А.А.
STUDY OVER BEHAVIORAL FEATURES OF ANIMALS IN VIEW OF FUNCTIONAL HEMISPHERIC ASYMMETRY ^{[№ 6 ' 2010]}
Based on the results of the research, the authors have discovered functional hemispheric asymmetry in regulation of rats motor performance control, their level of affectivity and aggression. The animals originally had differences in display of elements of individual behavior depending on functional hemispheric asymmetry.

Notova S.V., Miroshnikova S.A., lebedev S.V., Dubrovina G.V.
STUDYING OF HEAVY METALS LEVEL IN ORGANISM AT DIFFERENT PATHOLOGICAL CONDITIONS CONNECTED WITH VIOLATION OF IMMUNE SYSTEM FUNCTIONING ^{[№ 6 ' 2009]}

Miroshnikov S.A., Burtseva T.I., Golubkina N.A., Notova S.V., Skalniy А.V., Burlutskaya О.I.
HYGIENIC ASSESSMENT OF SELENIUM STATUS OF THE ORENBURG REGION ^{[№ 12 ' 2008]}
The work provides an assessment of the selenium status of the Orenburg Region population. The mean selenium concentration in hairs of the Orenburg residents ranged 0.153 to 0.405 mg/kg. Monitoring of selenium concentrations in food products is therefore very important for characteristics of the selenium geographical distribution. The report provides data on selenium concentrations in curd and whole milk produced in 25 districts of Orenburg Oblast. The microelement concentrations in curd ranged 102 to 341 mkg/kg, whole milk – 23 to 48 mkg /l. The mean selenium concentration in dairy products was 140 mkg/kg (curd) and 30 mkg /l (whole milk) accordingly. Heterogeneous distribution of selenium in the Orenburg Oblast dairy products has been recorded with the maximum values for the Northwestern Part – 149 mkg/kg for curd and 29 mkg /l for milk.