September 2015, № 9 (184)

Lebedeva E.N., Krasikov S.I., Sharapova N.V., Setko N.P., Zakharov A.A. LIPID AND ADIPOKINE PROFILE IN WORKERS OIL REFINERY The most important indicator of the health of society is the health of its employees. The chemical and oil refining industry production factors lead to the disruption of many metabolic processes. Thus, in those long-term employees in enterprises of petrochemical previously noted the presence of traditional risk factors for cardiovascular disease — an increase of total cholesterol, LDL cholesterol, TAG and IA due to lower HDL cholesterol. It was found that the number of individuals with overweight and obesity increases in proportion to length of service in hazardous work. Based on the fact that long-term exposure to toxic substances causes oxidative stress and has obesogenic effect (increases the total weight of the fatty tissue), the aim of study was to evaluate the lipid and adipokine profile of the workers of a petrochemical enterprises in the Orenburg region. A determining the level of leptin, adiponectin, TNF-α performed by ELISA, C-reactive protein (CRP) — turbidimetric method. The study shows that the values of CRP and TNF-α were elevated, indicating that the process of inflammation. Leptin, reflecting the total amount of adipose tissue in the body was significantly higher than normal (in females 2.5 times). Values adiponectin, in contrast, were extremely low, particularly in men: almost 10-fold decrease relative to normal. Thus, the individual long-term employees in enterprises of petrochemical noted the presence of both the traditional risk factors for cardiovascular disease — high cholesterol blood serum (the development of hypercholesterolemia) and a violation of the distribution of cholesterol between atherogenic and antiatherogenic lipoprotein fractions (dyslipoproteinemia) and pro-inflammatory nature of the changes adipokine profile. The data obtained allow us to recommend the use as informative biomarkers of the toxic effects of environment factors determining pro- and antiadipokines — leptin, adiponectin, TNF-α and C-reactive protein. Studies have shown that changes in lipid metabolism in the background of overweight are closely linked to the change in indicators adipokine regulation that dictates the need for the correction of these changes.Key words: lipid metabolism, adipokine profile, adiposopathy, oil refinery.

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About this article

Authors: Zaharov A.A., Lebedeva E.N., Krasikov S.I., Sharapova N.V., Setko N.P.

Year: 2015

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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