Aptikeeva R.F., Sharapova N.V., Kovalyova F.F.
THE ANTIOXIDANT STATUS AND INDICATORS OF VEGETATIVE BALANCE OF PATIENTS WITH ALCOHOLISM DEPENDING ON APPLICATION OF A COURSE OF ADAPTATION TO A PERIODIC NORMOBARICHESKY HYPOXIA ^{[№ 9 ' 2015]}
According to static data the number of alcoholics in Russia will amount to 5 000 000 people, 3.4 % of all population. Alcohol caused death by 33 % of menhood and by 15 % women, that is to say 500 000 people per year. In spite of the sufficiently progress in dipsomania treatment that is difficult to value the efficiency of taking medical measures and to prognosis the remission periode. In consideration of impotant role of oxidant stress in development of the addiction to the ethanol, it is essential question relating to research of new actions directed to increase the power of the antioxidant systems and to restriction of oxidant stress in the complex treatment of the people with the alcohol addiction syndrom. The object of this research is to determine the expedience of the use the adoptation to the circulating hypoxia of alcohol addicted patients treatment. Under the influence of adoptation to circulating normabaristic hypoxia the process lipoids perioxide by alcohol addicted patients returned to normal after holding the adoptation's course. The adoptation to the circulating normobaristic hypoxia favoured to increase of the power of the antioxidant systems. Thus, the results of the research denote, that the adoptation to circulating normobaristic hypoxia has an essentially influence on the character of the remission and the somastic condition. The valuable contribution of the adaptative therapy consists in the complete rejection from the ethonol both in the ordinary life's situations and in cases reminding the alcohol use. It allows to improve significantly a modern complex of actions directed to the dipsomania treatment and recommemd the course of the adoptation to circulating normobaristic hypoxia for its.

Lebedeva E.N., Krasikov S.I., Sharapova N.V., Setko N.P., Zakharov A.A.
LIPID AND ADIPOKINE PROFILE IN WORKERS OIL REFINERY ^{[№ 9 ' 2015]}
The most important indicator of the health of society is the health of its employees. The chemical and oil refining industry production factors lead to the disruption of many metabolic processes. Thus, in those long-term employees in enterprises of petrochemical previously noted the presence of traditional risk factors for cardiovascular disease — an increase of total cholesterol, LDL cholesterol, TAG and IA due to lower HDL cholesterol. It was found that the number of individuals with overweight and obesity increases in proportion to length of service in hazardous work. Based on the fact that long-term exposure to toxic substances causes oxidative stress and has obesogenic effect (increases the total weight of the fatty tissue), the aim of study was to evaluate the lipid and adipokine profile of the workers of a petrochemical enterprises in the Orenburg region. A determining the level of leptin, adiponectin, TNF-α performed by ELISA, C-reactive protein (CRP)  — turbidimetric method. The study shows that the values of CRP and TNF-α were elevated, indicating that the process of inflammation. Leptin, reflecting the total amount of adipose tissue in the body was significantly higher than normal (in females 2.5 times). Values adiponectin, in contrast, were extremely low, particularly in men: almost 10-fold decrease relative to normal. Thus, the individual long-term employees in enterprises of petrochemical noted the presence of both the traditional risk factors for cardiovascular disease — high cholesterol blood serum (the development of hypercholesterolemia) and a violation of the distribution of cholesterol between atherogenic and antiatherogenic lipoprotein fractions (dyslipoproteinemia) and pro-inflammatory nature of the changes adipokine profile. The data obtained allow us to recommend the use as informative biomarkers of the toxic effects of environment factors determining pro- and antiadipokines  — leptin, adiponectin, TNF-α and C-reactive protein. Studies have shown that changes in lipid metabolism in the background of overweight are closely linked to the change in indicators adipokine regulation that dictates the need for the correction of these changes.

Albakasova A.A., Veterkova Z.A., Evstifeeva G.Yu., Sumenko V.V., Krasikov S.I., Sharapova N.V.
CHARACTERISTICS OF LIPID SPECTRUM OF BLOOD SERUM IN THE NEWBORN WITH INTRAUTERINE GROWTH RETARDATION ^{[№ 1 ' 2012]}
In studies conducted by the authors, the connection between the serum lipid spectrum and the characteristics of prenatal development is defined. The features of the lipid spectrum of blood serum in newborns with intrauterine growth retardation, revealed the nature of dyslipoproteinemia and set the risk of atherosclerosis.

Alekhina E.M., Zakharova O.V., Tinkov A.A., Bogatov M.A., Sharapova N.V., Krasikov S.I.
INFLUENCE OF CHEMICAL FACTORS OF ENVIRONMENT ON ACTIVITY OF SUPEROXIDE SCAVENGERS AND CATALASES OF ORENBURG REGION POPULATION ^{[№ 6 ' 2009]}

Sharapova E.P.
TO THE HISTORY OF CHEKHOV'S STAGINGS ON ORENBURG STAGE ^{[№ 11 ' 2004]}
Information about stagings of Chekhov's plays in Orenburg theatre at the end of 19 century till present time is systematized in this article. Opinions of critics are given here and appraisal of modern performance is given here too.

Timoshinova S.V., Sharapova N.V., Mikhailova I.V., Krasikov S.I., Boev V.M., Smolyagin V.I.
THE INFLUENCE OF CHRONICAL INTOXICATION WITH CHROME AND BENZOL ON ANTIOXIDANT STATUS OF RATS ^{[№ 10 ' 2004]}
The influence of chronical intoxication with chrome and benzol on antioxidant status of rats was studied in the model experiment on rats of Wistar line. Rats got these matters with water during 45 days. The chemiluminescence indexes of experimented animals were in 1.5 higher than of animals of intact group. Chronical intoxication with potassium dichromate conducted to rise of catalysis activity and superoxide dismutase on the average in 20-40 %. At the same time, the activity of superoxide dismutase depression about in 20-30% at invariance of catalysis activity on the level of intact group was marked at benzol intoxication. Thus the conclusion about different ways of realization of pro-oxidant benzol and chrome influence was made in this article.