Lebedeva E.N., Krasikov S.I., Sharapova N.V., Setko N.P., Zakharov A.A.
LIPID AND ADIPOKINE PROFILE IN WORKERS OIL REFINERY ^{[№ 9 ' 2015]}
The most important indicator of the health of society is the health of its employees. The chemical and oil refining industry production factors lead to the disruption of many metabolic processes. Thus, in those long-term employees in enterprises of petrochemical previously noted the presence of traditional risk factors for cardiovascular disease — an increase of total cholesterol, LDL cholesterol, TAG and IA due to lower HDL cholesterol. It was found that the number of individuals with overweight and obesity increases in proportion to length of service in hazardous work. Based on the fact that long-term exposure to toxic substances causes oxidative stress and has obesogenic effect (increases the total weight of the fatty tissue), the aim of study was to evaluate the lipid and adipokine profile of the workers of a petrochemical enterprises in the Orenburg region. A determining the level of leptin, adiponectin, TNF-α performed by ELISA, C-reactive protein (CRP)  — turbidimetric method. The study shows that the values of CRP and TNF-α were elevated, indicating that the process of inflammation. Leptin, reflecting the total amount of adipose tissue in the body was significantly higher than normal (in females 2.5 times). Values adiponectin, in contrast, were extremely low, particularly in men: almost 10-fold decrease relative to normal. Thus, the individual long-term employees in enterprises of petrochemical noted the presence of both the traditional risk factors for cardiovascular disease — high cholesterol blood serum (the development of hypercholesterolemia) and a violation of the distribution of cholesterol between atherogenic and antiatherogenic lipoprotein fractions (dyslipoproteinemia) and pro-inflammatory nature of the changes adipokine profile. The data obtained allow us to recommend the use as informative biomarkers of the toxic effects of environment factors determining pro- and antiadipokines  — leptin, adiponectin, TNF-α and C-reactive protein. Studies have shown that changes in lipid metabolism in the background of overweight are closely linked to the change in indicators adipokine regulation that dictates the need for the correction of these changes.

Ermolaeva A.А., Setko A.G., Zinullin Y.Z.
ASSESSMENT OF INDUSTRIAL ORGANIZATIONS FOR THE ENVIRONMENT AND PUBLIC HEALTH ^{[№ 12 ' 2013]}
In this paper we consider the problem of environmental pollution poultry industry abroad sanitary protection zone, which by their function is a protective barrier that provides a sufficient level of safety. To solve the problem, we used a complex of modern hygiene, laboratory and instrumental and statistical methods. The paper used data from the regional system of social-hygienic and environmental monitoring. The study provided data characterizing the poultry industry as a source of environmental pollution and health impacts outside the SPZ of the enterprise, which is a violation of sanitary– epidemiological laws.

Matchin A.A., Setko N.P., Nefedova E.S.
DENTAL HEALTHH OF CHILDREN IN AREAS OF VARIOUS ANTHROPOGENIC POLLUTION ^{[№ 12 ' 2013]}
The article provides an assessment of dental diseases and intensity as well as heavy metals concentration levels in dental hard tissue of 12 years old children in Orenburg city (Russia) depending on the levels of anthropogenic environmental contamination in their residential areas.

Matchin A.A., Setko N.P., Nefedova E.S.
DENTAL HEALTHH OF CHILDREN IN AREAS OF VARIOUS ANTHROPOGENIC POLLUTION ^{[№ 10 ' 2013]}
The article provides an assessment of caries prevalence and intensity as well as heavy metals concentration levels in dental hard tissue of 12 years old children in Orenburg city (Russia) depending on the levels of anthropogenic environmental contamination in their residential areas.

Mikhailov A.N., Setko N.P.
ASSESSMENT OF ELEMENTARY PORTRAIT IN CHILDREN AND ADOLESCENTS LIVING 7 KM OFF THE COPPER COMPANY ^{[№ 1 ' 2011]}
The paper presents the estimate of chemical elements in hair of children and adolescents living at a distance of 7 km from the copper smelting plant.

Mikhailov A.N., Setko N.P.
APPRAISAL OF CHEMICAL ELEMENTS BALANCE OF CHILDREN AND TEENAGERS LIVING FOR A DISTANCE OF 5 KM FROM COPPER-SMELTING ENTERPRISE ^{[№ 4 ' 2010]}
The appraisal of chemical elements balance of children and teenagers living for a distance of 5 km from copper-smelting enterprise is given in this article.

Mikhaylov А.N., Setko N.P.
DISBALANCE OF MICROELEMENTS IN CHILDREN AND TEENAGERS LIVING IN THE AREA OF A COPPER SMELTERY ^{[№ 12 ' 2008]}
The article undertakes an assessment of the microelement disbalance in children and teenagers living in the area of a copper smeltery. The object of research was hairs. Possible options of replacement of the one element by another have been shown.

^{[№ 12 (app.1) ' 2006]}

Souetnova Yu.Yu., Setko N.P.
PRCULIARITIES OF FUNCTIONAL STATE OF CITY AND VILLAGE TEENAGER ORGANISM ^{[№ 12 ' 2006]}
The article gives the data of studies of anthropometrical parameters and functional state of basic systems of city and village 14-17 year teenager organism. The analysis of study results permitted to evaluate functional reserves and strain degree of regulatory mechanisms of integrative activity of cardiovascular teenager system.

Setko N.P., Malakhova U.G.
ECOLOGICAL CHARACTERISTIC OF ACTUAL EATING AND ALIMENTARY STATUS OF RURAL PUPILS OF ELEMENTARY SCHOOL, LIVING ON THE TERRITORY OF ORENBURG REGION ^{[№ 4 ' 2006]}
The analysis of actual eating of elementary school pupils living in rural areas of Orenburg region has shown that lack of essential nutrients is connected possibly with contamination of using food substances with xenobiotics. It influences on health indexes of children population, on children height and development, on their physical and psychophysiologic development, which demands eating correction of children of elementary school ages in changes of its structure, adequacy and rationality.

Setko N.P., Skripko I.V.
INFLUENCE OF GAS-CHEMICAL PRODUCTION FACTORS ON CHILDREN HEALTH CONDITION, MOTHERS OF WHOM ARE EMPLOYEES OF ORENBURG GAS-TRANSFERING PLANT AND LIVE IN THE REGION OF ITS LOCATION ^{[№ 12 ' 2005]}
The peculiarities of physical, neuropsychic development, adaptative potential of primary school age children, mothers of whom are employees of Orenburg gas-transfering plant and live in the region of its location, are discovered in this article. Got facts allows to make a conclusion that the level of physical and neuropsychic development, the level of adaptative opportunities of a children organism, mothers of whom are employees of gas-chemical production and who live in the region of its location are sharply decreased.

^{[№ 11 (app.1) ' 2005]}

Artemieva E.K., Setko N.P., Saprykin V.B.
CAUSE-EFFECT RELATION OF PREGNANCY AND ARTIFICIAL ABORTION COURSE, MICROELEMENTS CONTENTS IN PREGNANT WOMEN BIOSPHERE AND IN PLACENTA WITH ANTHROPOGENIC LOAD OF ENVIRONMENT ^{[№ 5 (app.1) ' 2005]}
Comparison of microelements contents in pregnant women biosphere and their fetuses with pollution of environment, is accompanied with differentiated permeation of differing chemical elements in pregnant women organism and it causes their histic distribution.

Setko A.G.
APPRAISAL OF CONSEQUENCES FOR POPULATION HEALTH, LIVING ON THE TERRITORY WITH DEVELOPED INDUSTRY ^{[№ 5 (app.1) ' 2005]}
The matters of influences of industrial enterprises emission to the ambient air of city with developed copper-smelting industry on population health, are regarded in this article. Also the appraisal of consequences at means of risk appraisal methodology is regarded here too.

Setko A.G., Ochneva G.I., Setko I.M.
FACTORS FORMED HEALTH OF CHILDISH POPULATION, LIVING ON URBANIZED TERRITORY AND RISK APPRAISAL OF ITS INFLUENCE ^{[№ 5 (app.1) ' 2005]}
The matters of early diagnostic in childish health deviation from influence of environment factors, in particular from pollution of ambient air, on the base of which it is possible to make management decisions of environment quality improvement, are regarded in this article.