2015, № 12 (187)

Chernykh D.V., Smirnov E.V., Bratko G.V., Gorbenko O.M., Shvayuk A.P., Obukhov O.O., Chernykh V.V., Trunov A.N. THE RELATIONSHIP BETWEEN THE ACTIVITY OF THE LOCAL INFLAMMATORY, IMMUNE AND PROLIFERATIVE PROCESSES IN THE PATHOGENESIS OF PROLIFERATIVE DIABETIC RETINOPATHYCurrently discussed the significance of the activity of the inflammatory process, immune response, imbalance of cytokines and other biologically active substances in the mechanisms of the development of proliferative diabetic retinopathy. However, many aspects of the pathogenesis of proliferative diabetic retinopathy remain insufficiently studied. In addition the relationship between the activity of the inflammatory process, vascular proliferation and disorders of the immune response in the pathogenesis of proliferative diabetic retinopathy are debated and require in-depth study. In the study was established the importance of the local inflammatory and proliferative processes and activation of the immune response in the pathogenesis of proliferative diabetic retinopathy, what is confirmed by the presence in the vitreous significantly higher concentrations of interleukin 4, 6, 8, 17A, vascular endothelial growth factor, monocyte chemotactic protein-1, transforming growth factor-beta 2, growth factor pigment epithelium and sIgA. Statistically analysis found presence correlative relationship between markers the reflecting activity immune inflammatory and proliferative processes [VEGF and TGF-β2 (r = 0.46, p < 0.05); VEGF and IL-17A (r = 0.45, p < 0.05); VEGF and IL-8 (r = 0.45, p < 0.05); PEDF and IL 17A (r = 0.48, p < 0.05); PEDF and IL-8 (r = 0.58, p < 0.05); IL-17A and IL-8 (r = 0.59, p < 0.05); IL-17A and IL-4 (r = 0.62, p < 0.05); IL-8 and IL-4 (r = 0.71, p < 0.01), and others]. The findings suggest an association between the development of local immuno-inflammatory and proliferative processes in the mechanisms of development of proliferative diabetic retinopathy.Key words: proliferative diabetic retinopathy, cytokines, growth factors.

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About this article

Authors: Chernyh D.V., Chernyh V.V., Obuhova O.O., Smirnov E.V., Bratko G.V., Gorbenko O.M., Shvayuk A.P., Trunov A.N.

Year: 2015

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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