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Orenburg State University january 25, 2022 RU/EN
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Chernykh D.V., Smirnov E.V., Bratko G.V., Gorbenko O.M., Shvayuk A.P., Obukhov O.O., Chernykh V.V., Trunov A.N.
THE RELATIONSHIP BETWEEN THE ACTIVITY OF THE LOCAL INFLAMMATORY, IMMUNE AND PROLIFERATIVE PROCESSES IN THE PATHOGENESIS OF PROLIFERATIVE DIABETIC RETINOPATHY [№ 12 ' 2015]
Currently discussed the significance of the activity of the inflammatory process, immune response, imbalance of cytokines and other biologically active substances in the mechanisms of the development of proliferative diabetic retinopathy. However, many aspects of the pathogenesis of proliferative diabetic retinopathy remain insufficiently studied. In addition the relationship between the activity of the inflammatory process, vascular proliferation and disorders of the immune response in the pathogenesis of proliferative diabetic retinopathy are debated and require in-depth study. In the study was established the importance of the local inflammatory and proliferative processes and activation of the immune response in the pathogenesis of proliferative diabetic retinopathy, what is confirmed by the presence in the vitreous significantly higher concentrations of interleukin 4, 6, 8, 17A, vascular endothelial growth factor, monocyte chemotactic protein-1, transforming growth factor-beta 2, growth factor pigment epithelium and sIgA. Statistically analysis found presence correlative relationship between markers the reflecting activity immune inflammatory and proliferative processes [VEGF and TGF-β2 (r=0.46, p<0.05); VEGF and IL-17A (r=0.45, p<0.05); VEGF and IL-8 (r=0.45, p<0.05); PEDF and IL 17A (r=0.48, p<0.05); PEDF and IL-8 (r=0.58, p<0.05); IL-17A and IL-8 (r=0.59, p<0.05); IL-17A and IL-4 (r=0.62, p<0.05); IL-8 and IL-4 (r=0.71, p<0.01), and others]. The findings suggest an association between the development of local immuno-inflammatory and proliferative processes in the mechanisms of development of proliferative diabetic retinopathy.

Gamm T.A., Smirnova N.V., Gamm A.A.
INFLUENCE OF HEAVY OIL ON THE ECOLOGICAL STATE OF SOIL AND GROUNDWATER AFTER THE TERMINATION OF THE COMPANY [№ 10 ' 2015]
Oil and petroleum products are the most common contaminants of human origin in the environment. Some authors consider that at low levels of oil pollution, from0.06 to 1.22%, the establishment of uniform permissible residual oil concentrations in soils is impossible, since it depends on many factors. SuslonovA.V. for the first time found that oil pollution of soil 1–20-year-old leads to changes in floristic composition and reduce total aboveground plant biomass is 2.2times the total projective cover 1.7times. Also found that oil production affect the state of the small rivers of Bashkortostan and the Orenburg region.

Smirnova E.V.,Tsiganova I.Y.
PROBLEMS OF FORMATION AND THE DISCLOSURE OF INFORMATION BY SEGMENT IN THE STRAEGIC REPORTING [№ 12 ' 2013]
The problems of formation and the disclosure of information by business segment in strategic accounts organization is represented in the article: segmentation; application of management approach that is new for Russian practice; the absence of internal standards regulating the form and content of the strategic reporting.

Smirnova E.V., Spirina A.M.
SYNTHETIC APPROACH TO THE ASSESSMENT OF EFFICIENCY OF STRATEGY OF THE INDUSTRIAL ENTERPRISES [№ 13 ' 2012]
In article shortcomings of used techniques of an assessment of efficiency of strategy of the enterprises are generalized. The complex of the indicators, allowing to carry out an integrated assessment of internal and external efficiency of strategy from positions of profitability, efficiency and productivity is offered

Khvostikov A.S., Kosmynin A.V., Schetinin V.S., Smirnov A.V., Blinkov S.S.
THE CONTROL OF THE SPINDLE ON GAS-STATIC BEARING THE METOD OF VIBRATION ACOUSTIC ISSUE [№ 9 ' 2012]
The technique of the control of position of a spindle on gas-static bearing is stated by a method of vibrating acoustic issue. The description of the experimental stand and the measuring equipment is resulted.

Smirnova N.A.
ORTHODOX TRADITION OF STUDYING OF HISTORY OF EUROPEAN REFORMATION AND PROTESTANTISM [№ 5 ' 2012]
The article deals with problems of the modern historiography of Reformation and the feasibility of reference to the works of Orthodox researchers of the XIX century. On examples of works of V. Sokolov, V. Mikhaylovsky, h. Retivtsev and others author argues the research and worldview importance of Orthodox tradition of studying of the history of the European Reformation and Protestantism — especially Anglicanism.

Smirnova N.A.
RELATIONSHIP OF SECULAR AND SPIRITUAL POWER IN THE ENGLISH REFORMERS UNDERSTANDING [№ 1 ' 2012]
This article discusses the problems of establishing a new system of relations between secular and spiritual authority in the XVI century on the example of England. The changes are associated with the emergence of Protestantism in the British version — Anglicanism, established mainly at the behest of the monarch — Henry VIII Tudor, with the help of his faithful ally — Archbishop of Canterbury Thomas Cranmer, a prominent theologian of his time.

Aralbaev Z.T., Smirnova E.V.
METHODICAL ASPECTS OF FORMATION OF SYSTEM OF INDICATORS OF INDUSTRIAL ENTERPRISES IN THE CONDITIONS OF BUSINEES STRUGGLE [№ 13 ' 2011]
Use of system of indicators in an operation of enterprises allows to achieve its more effective functioning as it displays a current condition and development strategy, gives the chance to a management to control its realization and achievement of necessary financial results.

Smirnova E.V.
THE PURPOSEFUL ORIENTATION OF THE MODIFICATION OF THE SYSTEMS OF PLANNING INDUSTRIAL ENTERPRISES UNDER THE CONDITIONS OF THE MARKET ECONOMY [№ 8 ' 2011]
The need of using the modification as the tool of the adaptation of the systems of planning industrial enterprises to the conditions of the market economy is substantiated. The purposeful orientators of modification and the separate tools of their realization are determined.

Smirnova E.V.
THE EVOLUTION OF THE SYSTEMS OF PLANNING ENTERPRISES, THEIR MODIFICATION AND INTERRELATION WITH ECONOMIC DEVELOPMENT [№ 8 ' 2011]
The appearance of modifications of the base (for the concrete economic system) model of planning system in the dependence on the level of economic development is theoretically substantiated. Development stages of planning system under the conditions of the administrative- command and market economy are isolated.

Smirnov A.V.
SELF-EDUCATION IN THE DEVELOPING SYSTEMS OF CONTINUOUS EDUCATION [№ 6 ' 2011]
The article deals with external and internal prerequisites and conditions for self-education as a part of the continuous education system. A creative activity, which involves the formation of the unity of education, practice and self-education, is considered in this work.

Torshin V.I., Sveshnikov D.S., Smirnov V.M., Yurasova I.A.
VAGAL MOTOR RESPONCES OF GASTROINTESTINAL TRACT ENHANCED BY THE SEROTONINOREACTIVE STRUCTURES [№ 5 ' 2011]
The mechanical activity of the stomach, duodenum and ascending colon were recorded in acute experiments in 29 rabbits. The distal part of the vagus nerve was electrically stimulated in intact animals and on the serotonin adipate background. It was shown that serotonin enhances motor vagal reactions, increasing both intensity and in some cases the duration. Concluded that between serotoninergic structures that regulate the motility of the gastrointestinal tract and parasympathetic portion of the autonomic nervous systemthe functional interaction exists.

Smirnova O.A.
THE NOVEL "OBLOMOV" AND DISCUSSION ABOUT ITS HERO IN XIX — BEGINNING OF XX CENTURY AS SOURCE FOR RUSSIAN NATIONAL CHARACTER SPECIFIC UNDERSTANDING STUDYING [№ 4 ' 2011]
The article is devoted to the analysis of the discussion that took place in the Russian intelligentsia environment in the second half of the XIX — beginning of the XX century, on the occasion of "Oblomov" by I.A.Goncharov. The author shows that this novel was perceived by the main part of the intellectual society like a concentrated expression of national traits of character and a world outlook of a Russian person.

Smirnova I.G.
ON THE PROBLEM OF NECESSITY OF THE NEW LEGAL PROCEDURE STRATEGY FORMATION [№ 3 ' 2011]
The author conducted a survey on legal procedure strategy criteria: reasonability and practicability and defined necessary conditions of their realization: keeping and respecting of human rights, reality, economy, effectiveness. The author proposed the strategy of reasonable social practicability, based on the common law idea, having methodological basis and taking into account positive criminal-legal law features.

Smirnovskaya S.I.
ON THE PROBLEM OF SOCIAL-LAW SUPPORTING FAMILIES WITH CHILDREN IN ORENBURG REGION [№ 3 ' 2011]
Social family and children support — is a very important aspect of healthy way of living development. Key words: health and life of a child, the development of quality and healthy life of a teenager, state and public children and family support.


Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

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