Chernykh D.V., Smirnov E.V., Bratko G.V., Gorbenko O.M., Shvayuk A.P., Obukhov O.O., Chernykh V.V., Trunov A.N.
THE RELATIONSHIP BETWEEN THE ACTIVITY OF THE LOCAL INFLAMMATORY, IMMUNE AND PROLIFERATIVE PROCESSES IN THE PATHOGENESIS OF PROLIFERATIVE DIABETIC RETINOPATHY ^{[№ 12 ' 2015]}
Currently discussed the significance of the activity of the inflammatory process, immune response, imbalance of cytokines and other biologically active substances in the mechanisms of the development of proliferative diabetic retinopathy. However, many aspects of the pathogenesis of proliferative diabetic retinopathy remain insufficiently studied. In addition the relationship between the activity of the inflammatory process, vascular proliferation and disorders of the immune response in the pathogenesis of proliferative diabetic retinopathy are debated and require in-depth study. In the study was established the importance of the local inflammatory and proliferative processes and activation of the immune response in the pathogenesis of proliferative diabetic retinopathy, what is confirmed by the presence in the vitreous significantly higher concentrations of interleukin 4, 6, 8, 17A, vascular endothelial growth factor, monocyte chemotactic protein-1, transforming growth factor-beta 2, growth factor pigment epithelium and sIgA. Statistically analysis found presence correlative relationship between markers the reflecting activity immune inflammatory and proliferative processes [VEGF and TGF-β2 (r = 0.46, p < 0.05); VEGF and IL-17A (r = 0.45, p < 0.05); VEGF and IL-8 (r = 0.45, p < 0.05); PEDF and IL 17A (r = 0.48, p < 0.05); PEDF and IL-8 (r = 0.58, p < 0.05); IL-17A and IL-8 (r = 0.59, p < 0.05); IL-17A and IL-4 (r = 0.62, p < 0.05); IL-8 and IL-4 (r = 0.71, p < 0.01), and others]. The findings suggest an association between the development of local immuno-inflammatory and proliferative processes in the mechanisms of development of proliferative diabetic retinopathy.

Trunov A.N., Arbeneva N.C., Gorbenko О.М., Shvayuk А.P., Obukhova O.O.
IMBALANCE CYTOKINES IN THE TEAR FLUID IN PATIENTS WITH AUTOIMMUNE UVEITIS ^{[№ 4 ' 2013]}
Study activity the local immunoinflammatory process in patients with autoimmune uveitis. We examined 60 patients with autoimmune uveitis (study group) not receiving basic treatment system autoimmune disease and 20 control patients. In the lacrimal fluid of patients before treatment, by enzyme immunoassay, was conducted determination of IL-17A, IL-8, IL-6, IL-4. Found that in the pathogenesis of uveitis associated with systemic autoimmune diseases, an important role is the development of local immunoinflammatory process, which is manifested in a significant increase in tear fluid of surveyed patients, concentrations of proinflammatory cytokines IL-17A, IL-8, that accompanied by increased concentrations of IL-4, IL-6, which play a significant role in the development of autoimmune response and chronic inflammatory processes in their relationship, which was confirmed data correlation analysis

Varvarinsky Е.V., Gorbenko О.М., Shvayuk А.P., Bratko G.V., Trunov A.N., Chernykh V.V.
CONTENTS VASCULAR ENDOTHELIAL GROWTH FACTOR AND SEVERAL CYTOKINES IN THE VITREOUS BODY PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHY ^{[№ 12 ' 2012]}
Conducted determination of the concentrations of vascular endothelial growth factor, interleukin 17A and 10 in the vitreous body of patients with proliferative diabetic retinopathy. Found that in the pathogenesis of proliferative diabetic retinopathy activity of local immuno-inflammatory process (increased concentrations of IL-17A) and vascular proliferation (increased concentrations of vascular endothelial growth factor) plays significant role. Identified correlations indicate the relationship of these processes.