2015, № 12 (187)

Zainutdinova G.H., Aznabaeva L.F., Faizullin A.S. EXTRACELLULAR PEROXIDASE ACTIVITY OF BLOOD IN NEWBORN INFANTS WITH RISK OF RETINOPATHY OF PREMATURITYThe problem of early diagnosis of retinopathy of prematurity (ROP) at the present stage remains very relevant due to the increasing number of children with this pathology. The important point in the pathogenesis of ROP is the development of oxidative stress associated with increased production of free radicals and their destructive effects on various organs, including the retina. Several studies proved that the development of ROP occurs on the background of reducing the activity of antioxidant enzymes superoxide dismutase, glutathione peroxidase. In antioxidant protection has also participated peroxidase system, in particular, the enzyme peroxidase introduced into the extracellular space during phagocytosis, the cellular damage of the organs, tissues and catalyzes the oxidation of various substances with hydrogen peroxide. One of the indicators to assess the state of the peroxidase system is the determination of blood of activity extracellular peroxidase. However, data on the participation of the extracellular peroxidase activity (ЕPA) in blood development and character of the clinical course of ROP in the available scientific literature, the authors found. In this work results of investigations of indicator oxidant-antioxidant protection — extracellular peroxidase activity of the blood in 3-4 week 63 preterm infants. Conducted research indicator of extracellular peroxidase activity in serum in preterm infants showed that 48.8 % of infants with reduced values was the development of some clinical forms of retinopathy of prematurity. The majority (61.9 %) of them developed stage I, almost a third (28,6 %) showed progression to stage II–III, in fewer cases diagnosed (9.5 %) of posterior aggressive form of the disease. Research conducted by the authors found that the risk of developing ROP rises upon detection of concomitant somatic pathology of organs of breathing and circulation with reduced activity of extracellular peroxidases of the blood serum in preterm infants at 3–4 weeks of age.Key words: retinopathy of prematurity, extracellular peroxidase activity of blood.

Download

References:

1. Absalikovа D. K. Rationale of combined systemic nonsteroidal anti-inflammatory and antioxidant therapy of endogenous uveitis: Аbstract diss. ... candidate. medical sciences. — Moscow, 2012. — 130 pp.

2. Aznabaeva L. F., Kilsenbaeva F. A., Aref'eva N.A. Method of determination of the peroxidase activity in biological fluids. The patent for the invention № 2180114, dated 27.02.2002 (Priority dated 13.10.2000).

3. Astasheva I. B., Kan I.G., Degtyarev D. N., Degtyarev A. V. Peculiarities of development and course of retinopathy of prematurity using new approaches to respiratory therapy at the stage of primary resuscitation of newborns // Herald OSU. — 2014. — No. 12. — pp. 17 — 19.

4. Gilmanova V. G. Prediction of course and therapy of bacterial conjunctivitis in children: Аbstract diss. ... candidate. medical sciences. — Krasnoyarsk, 2012. — 122 pp.

5. Katargina L.A., Kogoleva L.V. Retinopathy of prematurity. In book: Neroev V.V., edition. Chosen lectures on children's ophthalmology. Moscow.: GEOTAR-media. — 2009; part 2: pp. 27 — 61.

6. Mukhamedyanova A. S. Clinical and immunological criteria for predicting the course and treatment of age-related macular degeneration: Аbstract diss. ... candidate. medical sciences. — Chelyabinsk, 2008. — 115 pp.

7. Nikolaeva G.V. The analysis of risk factors of development of a retinopathy of prematurity in the intensive care unit and intensive therapy of newborns. Russian pediatric ophthalmology. — 2010. — № 3. — pp. 21-22.

8. Terekhina N. A., Petrovich Y.A. Laboratory work. — 1990. — No. 2. — P. 13 — 18.

9. Khvatova A. V., Katargina L. A. Retinopathy of prematurity. Hereditary and congenital diseases of the retina and optic nerve // In book: A. M. Shamshinova, edition.. Moscow.: Medicine, 2001. — pp. 385 — 418.

10. Cole C. Making Sense of Clinical Determinants of Retinopathy of Prematurity / J. Pediatr. — 2010. — Vol. 157, № 1. — P. 5-7.

11. Ellsbury D.L., Ursprung R. Comprehensive оxygen мanagement for the рrevention of retinopathy of prematurity: the pediatrix experience // Clin. Perinatol. — 2010. — Vol. 37, №1. — Р. 203 — 215.

12. Garg U., Jain A., Singla P. et al. Free Radical Status in Retinopathy of Prematurity / Ind. J. Clin. Biochem. — 2012. — Vol. 27, № 2. — Р. 196 — 199.

13. Li S.Y., Fu Z.J., Lo A.C. Hypoxia-induced oxidative stress in ischemic retinopathy // Oxidative Medicine and Cellular Longevity. — 2012. — 10 pp.

14. Lee J.W., Davis J.M. Future applications of antioxidants in premature infants // Curr Opin Pediatr. — 2011. — Vol. 23, №2. — Р. 161-166.

15. Тhe classification of retinopathy of prematurity revisited // Arch. Ophthalmol. — 2005. — Vol. 123. — P. 991 — 999.

16. Loui A, Raab A, Maier R.F., et al. Trace elements and antioxidant enzymes in extremely low birthweight infants / J Trace Elem Med Biol. — 2010. — Vol. 24, №2. P. 111-118.

About this article

Authors: Fayzullina A.S., Zaynutdinova G.H., Aznabaeva L.F.

Year: 2015

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

© Электронное периодическое издание: ВЕСТНИК ОГУ on-line (VESTNIK OSU on-line), ISSN on-line 1814-6465
Зарегистрировано в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций
Свидетельство о регистрации СМИ: Эл № ФС77-37678 от 29 сентября 2009 г.
Учредитель: Оренбургский государственный университет (ОГУ)
Главный редактор: С.А. Мирошников
Адрес редакции: 460018, г. Оренбург, проспект Победы, д. 13, к. 2335
Тел./факс: (3532)37-27-78 E-mail: vestnik@mail.osu.ru