Zainutdinova G.H., Aznabaeva L.F., Faizullin A.S.
EXTRACELLULAR PEROXIDASE ACTIVITY OF BLOOD IN NEWBORN INFANTS WITH RISK OF RETINOPATHY OF PREMATURITY ^{[№ 12 ' 2015]}
The problem of early diagnosis of retinopathy of prematurity (ROP) at the present stage remains very relevant due to the increasing number of children with this pathology. The important point in the pathogenesis of ROP is the development of oxidative stress associated with increased production of free radicals and their destructive effects on various organs, including the retina. Several studies proved that the development of ROP occurs on the background of reducing the activity of antioxidant enzymes superoxide dismutase, glutathione peroxidase. In antioxidant protection has also participated peroxidase system, in particular, the enzyme peroxidase introduced into the extracellular space during phagocytosis, the cellular damage of the organs, tissues and catalyzes the oxidation of various substances with hydrogen peroxide. One of the indicators to assess the state of the peroxidase system is the determination of blood of activity extracellular peroxidase. However, data on the participation of the extracellular peroxidase activity (ЕPA) in blood development and character of the clinical course of ROP in the available scientific literature, the authors found. In this work results of investigations of indicator oxidant-antioxidant protection — extracellular peroxidase activity of the blood in 3-4 week 63 preterm infants. Conducted research indicator of extracellular peroxidase activity in serum in preterm infants showed that 48.8 % of infants with reduced values was the development of some clinical forms of retinopathy of prematurity. The majority (61.9 %) of them developed stage I, almost a third (28,6 %) showed progression to stage II–III, in fewer cases diagnosed (9.5 %) of posterior aggressive form of the disease. Research conducted by the authors found that the risk of developing ROP rises upon detection of concomitant somatic pathology of organs of breathing and circulation with reduced activity of extracellular peroxidases of the blood serum in preterm infants at 3–4 weeks of age.