|
|
|
Varvarinsky Е.V., Gorbenko О.М., Shvayuk А.P., Bratko G.V., Trunov A.N., Chernykh V.V. CONTENTS VASCULAR ENDOTHELIAL GROWTH FACTOR AND SEVERAL CYTOKINES IN THE VITREOUS BODY PATIENTS WITH PROLIFERATIVE DIABETIC RETINOPATHYConducted determination of the concentrations of vascular endothelial growth factor, interleukin 17A and 10 in the vitreous body of patients with proliferative diabetic retinopathy. Found that in the pathogenesis of proliferative diabetic retinopathy activity of local immuno-inflammatory process (increased concentrations of IL-17A) and vascular proliferation (increased concentrations of vascular endothelial growth factor) plays significant role. Identified correlations indicate the relationship of these processes.Key words: diabetic retinopathy, cytokines, vascular endothelial growth factor
References:
1. Ocular manifestations of diabetes / Ed. Balashevich L.I. – St. Petersburg, 2004. – 382 p.
2. Libman E.S., Shahova E.V. Blindness and disability due to pathology of the vision in Russia // Journal of Ophthalmology. – 2006. – №1. – P. 35-37.
3. Slepova O.S., Neroev V.V. Ilyukhin P.A., Sarygina O.I. Immunological control of in the surgical treatment of patients with proliferative diabetic retinopathy with preliminary introduction to the vitreous Lucentis / / Russian Ophthalmological Journal. – 2012. – №1. – P.69-74.
4. Chernykh V.V., Lysikov A.G., Obukhova O.O., Gorbenko O.M., Shvayuk A.P., Trunov A.N. Features of local immunoinflammatory process at nonproliferative diabetic retinopathy // Bulletin of the Novosibirsk State University.– 2011. – Vol.9, №1. – P.164-168.
5. Khodzhayev N.S., Chernykh V.V., Romenskaya I.V., Kuntysheva K.E., Trunov A.N. Effect of lasercoagulation retina on clinical-laboratory parameters in patients diabetic macular edema / / Bulletin of the Novosibirsk State University.– 2011. – Vol.9, №4. – P.48-53.
6. Bhavsar A.R. Diabetic retinopathy: the latest in current management // Retina. – 2006. – Vol. 26, №6. – P. 71-79.
7. Citirik M., Kabatas E.U., Batman C., Akin K.O., Kabatas N. Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy // Ophthalmic Res.-2012.– Vol.47, №1.– Р.7-12.
8. Lim A., Stewart J., Chui T.Y., Lin M., Ray K., Lietman T., Porco T., Jung L., Seiff S., Lin S. Prevalence and risk factors of diabetic retinopathy in a multi-racial underserved population. // Ophthalmic Epidemiol. – 2008. – №6. -Р. 402-409.
9. Kollias A.N., Ulbig M.W. Diabetic retinopathy: Early diagnosis and effective treatment // Dtsch. Arztebl. Int. -2010.– №5.– P. 75-83.
10. Kowluru R.A., Zhong Q., Kanwar M. Metabolic memory and diabetic retinopathy: role of inflammatory mediators in retinal pericytes // Exp. Eye Res.-2010. – №5.-Р. 617-623.
11. Murugeswari P., Shukla D., Rajendran A., Kim R., Namperumalsamy P., Muthukkaruppan V. Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease // Retina.– 2008. -№6. – Р. 817-824.
12. Pennock S., Kazlauskas A. Vascular endothelial growth factor A competitively inhibits platelet-derived growth factor (PDGF)-dependent activation of PDGF receptor and subsequent signaling events and cellular responses // Mol. Cell Biol.-2012.-Vol.32,№10.-Р.1955-1966.
13. Rasier R., Gormus U., Artunay O., Yuzbasioglu E., Oncel M., Bahcecioglu H. Vitreous levels of VEGF, IL-8, and TNF-alpha in retinal detachment // Curr. Eye Res.-2010. – Vol.35, №6.– Р.– 505-509.
14. Symeonidis C, Papakonstantinou E, Androudi S, Rotsos T, Diza E, Brazitikos P, Karakiulakis G, Dimitrakos S.A. Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy // Cytokine.– 2011. – Vol.54, №2. – Р. 212-217.
15. Sadaka A., Giuliari G.P. Proliferative vitreoretinopathy: current and emerging treatments // Clin. Ophthalmol. – 2012. –№6. -Р. 1325-1333.
About this article
Authors: Chernyh V.V., Gorbenko O.M., Shvayuk A.P., Varvarinskiy E.V., Bratko G.V., Trunov A.N.
Year: 2012
|
|
Editor-in-chief |
Sergey Aleksandrovich MIROSHNIKOV |
|
|