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Kozminykh V.O., Kirillova E.A., Goncharov V.I., Golotsvan A.V. TERNARY TANDEM HETEROCYCLIZATION OF ACETOPHENONE WITH DIETHYLCSLAD AND M-AMINOPHENOL – NEW METHOD FOR GETTING OF 7-HYDROXY-4-PHENYLQUINOLIN-2-CARBOXYLIC ACIDThe ether condensation of acetophenone with diethyl oxalate and m-aminophenol in presence of sodium followed by treatment of the reaction mixture with acetic acid proceeds unusually to preparatively yield 7-hydroxy-4-phenylquinoline-2-carboxylic acid. This three component tandem heterocyclization is proposed to be used as a new regiodirected method of quinoline-2-carboxylic (quinaldinic) acid synthesis. The reaction pathway and structure peculiarities of the prepared compound as well as alternative structures are under discussion.
About this article
Authors: Kozminyh V.O., Kirillova E.A., Goncharov V.I., Golotsvan A.V.
Year: 2008
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Editor-in-chief |
Sergey Aleksandrovich
MIROSHNIKOV |
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