Babushkin A.E., Orenburkina O.I., Matyukhina E.N.
MONITORING OF PRIMARY OPEN ANGLE GLAUCOMA PROGRESSION ON THE BACKGROUND OF MONO- AND COMBINED ANTIHYPERTENSIVE THERAPY ^{[№ 12 ' 2015]}
Purpose of the study is to assess comparatively the frequency of primary open angle glaucoma (POAG) progression along with prolonged mono- and combined antihypertensive therapy at regular medical check-up of patients. It was performed a retrospective analysis of out-patient medical records in 85 patients (165 eyes) with POAG stage I–III compensated within average rate of intraocular pressure (IOP), which were followed for 5–7 years. Of these, 64 patients (124 eyes) received topical antihypertensive treatment in the form of instillations with only non-selective beta-blocker timolol 0.5 % and 21 patients (41 eyes) — non-fixed combination therapy (20 eyes — timolol in combination with cholinomimetic pilocarpine and in 21 eyes — timolol with prostaglandins, mainly xalatan). Progression of the disease was defined by the state of vision fields (kinetic perimetry) and optic disc (ophthalmoscopy). The analysis showed that the POAG progression against the IOP compensated within average rate in patients treated with non-selective beta-blocker timolol was observed in 1.3 times more frequently than in patients treated with non-fixed combination therapy — β-blockers with prostaglandin drugs or cholinomimetics (62.1 % vs 46.3 %). Thus destabilization of the disease while using a combination of timolol with drugs of prostaglandin series was marked by almost 2 times less than at combination with pilocarpine (33.3 % vs 60.0 %). The combination therapy using prostaglandin drugs that can reduce the incidence of POAG progression must be much more widely and actively used as the initial treatment of primary open angle glaucoma.

Shevchuk N.E., Babushkin A.E., Orenburkina O.I., Matyukhina E.N.
CONCENTRATIONS OF TGF-β2 IN TEAR AND SERUM IN PATIENTS WITH OPEN-ANGLE GLAUCOMA IN THE DYNAMICS OF SURGICAL TREATMENT AND ITS ROLE IN EXCESSIVE SCARRING AFTER ANTI-GLAUCOMA OPERATIONS ^{[№ 12 ' 2015]}
To study ТGF-β2 level in lacrimal fluid (LF) and blood serum (BS) in patients with primary open angle glaucoma (POAG) in the course of surgical treatment so as to estimate predictability of antiglaocomatous operations outcome. 23 patients with POAG were analyzed for TGF-β2 concentration in blood serum and lacrimal fluid in the course of surgical treatment. Deep sclerectomy (DS) was applied as an antiglaocomatous operation. TGF-β2 concentration in blood serum and lacrimal fluid was investigated before the operation, one week, 1, 3 and 6 months thereafter. An increased level of TGF-β2 in blood serum and lacrimal fluid was detected in operated patients with advanced stages of POAG. An ocular hypertension relapse due to excessive postoperative scarring was accompanied by TGF-β2 level increase with its peak serum concentration 3 months after penetrating DS. High local preoperative level of TGF-β2 may be applied as a prognostic marker for early excessive postoperative scarring in newly formed intraocular fluid outflow tracts.

Babushkin A.E., Orenburkina O.I.
OPTIMIZATION OF THE SURGICAL TREATMENT OF PRIMARY OPEN-ANGLE AND SECONDARY GLAUCOMA ^{[№ 12 ' 2014]}
The article gives an algorithm for a differentiated approach to the surgical treatment of primary open-angle glaucoma and secondary glaucoma with use of advanced glaucoma interventions (non-penetrating, partially fistulizing, fistulizing and combined), developed on the basis of a complex of clinical studies, the results of surgical treatment of 424 patients (438 eyes) with a follow — up to 3 years (304 patients, 311 eyes).

Aznabaev M.T., Orenburkina O.I., Avertsev G.N.
STUDYING OF HEMODYNAMICS CHANGES IN CENTRAL ARTERY OF RETINA AFTER CATARACT EXTRACTION OF PANCREATIC DIABETES PATIENTS ^{[№ 13 ' 2004]}