2015, № 12 (187)

Shevchuk N.E., Babushkin A.E., Orenburkina O.I., Matyukhina E.N. CONCENTRATIONS OF TGF-β2 IN TEAR AND SERUM IN PATIENTS WITH OPEN-ANGLE GLAUCOMA IN THE DYNAMICS OF SURGICAL TREATMENT AND ITS ROLE IN EXCESSIVE SCARRING AFTER ANTI-GLAUCOMA OPERATIONSTo study ТGF-β2 level in lacrimal fluid (LF) and blood serum (BS) in patients with primary open angle glaucoma (POAG) in the course of surgical treatment so as to estimate predictability of antiglaocomatous operations outcome. 23 patients with POAG were analyzed for TGF-β2 concentration in blood serum and lacrimal fluid in the course of surgical treatment. Deep sclerectomy (DS) was applied as an antiglaocomatous operation. TGF-β2 concentration in blood serum and lacrimal fluid was investigated before the operation, one week, 1, 3 and 6 months thereafter. An increased level of TGF-β2 in blood serum and lacrimal fluid was detected in operated patients with advanced stages of POAG. An ocular hypertension relapse due to excessive postoperative scarring was accompanied by TGF-β2 level increase with its peak serum concentration 3 months after penetrating DS. High local preoperative level of TGF-β2 may be applied as a prognostic marker for early excessive postoperative scarring in newly formed intraocular fluid outflow tracts.Key words: POAG, tear, serum, TGF-β2, scarring.

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About this article

Authors: Matyuhina E.N., Shevchuk N.E., Babushkin A.E., Orenburkina O.I.

Year: 2015

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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