Vestnik On-line
Orenburg State University november 20, 2024 š RU/EN
Current issue About edition Editorial board To authors Subscription Our authors Files
Headings of Vestnik
Pedagogics
Psychology
Other

Search
Author Article
ðÏÄÁÞÁ ÓÔÁÔÅÊ
Vak
áÎÔÉÐÌÁÇÉÁÔ
Orcid
Viniti
üâó ìÁÎØ
Rsl
ìÉÃÅÎÚÉÑ Creative Commons

2015, №š12š(187)



Shevchuk N.E., Babushkin A.E., Orenburkina O.I., Matyukhina E.N. CONCENTRATIONS OF TGF-β2 IN TEAR AND SERUM IN PATIENTS WITH OPEN-ANGLE GLAUCOMA IN THE DYNAMICS OF SURGICAL TREATMENT AND ITS ROLE IN EXCESSIVE SCARRING AFTER ANTI-GLAUCOMA OPERATIONSTo study ôGF-β2 level in lacrimal fluid (LF) and blood serum (BS) in patients with primary open angle glaucoma (POAG) in the course of surgical treatment so as to estimate predictability of antiglaocomatous operations outcome. 23špatients with POAG were analyzed for TGF-β2 concentration in blood serum and lacrimal fluid in the course of surgical treatment. Deep sclerectomy (DS) was applied as an antiglaocomatous operation. TGF-β2 concentration in blood serum and lacrimal fluid was investigated before the operation, one week, 1, 3 and 6šmonths thereafter. An increased level of TGF-β2 in blood serum and lacrimal fluid was detected in operated patients with advanced stages of POAG. An ocular hypertension relapse due to excessive postoperative scarring was accompanied by TGF-β2 level increase with its peak serum concentration 3šmonths after penetrating DS. High local preoperative level of TGF-β2 may be applied as a prognostic marker for early excessive postoperative scarring in newly formed intraocular fluid outflow tracts.Key words: POAG, tear, serum, TGF-β2, scarring.

Download
References:

1. Vasilenkova L.V., GankovskajÁ L.V., Kalinina O.M. Lokal'najÁ citokinoterapijÁ pri fistuliziruyushih antiglaukomatoznyh operacijÁh // Sb. nauch. st. "Oftal'moimmunologijÁ. Itogi i perspektivy".š— M., 2007.š— S. 79-84.

2. Zahidov A.B. Kombinirovannoe hirurgicheskoe lechenie pervichnoi otkrytougol'noi glaukomy s lokal'noi immunokorrekciei reparativnyh processov: Avtoref. … kand.med.nauk, M., 2010.š— 20 s.

3. Kurysheva N.I., GankovskajÁ L.V., Koval'chuk L.V. i dr. Immunologicheskie aspekty izbytochnogo rubcevanijÁ tkanei glaza posle antiglaukomatoznyh operacii.š— Mater. III Evro-Aziatskoi konf. po oftal'mohirurgii.š— Ekaterinburg, 2003.š— S. 79-80.

4. Lebedev O.I., Surov A.V. Immunnye mehanizmy reguljÁcii reparativnyh processov posle antiglaukomatoznyh operacii // Sb. nauch. st. "Oftal'moimmunologijÁ. Itogi i perspektivy".š— M., 2007.š— S. 163-165.

5. Lovpache D.N. Kliniko-immunologicheskoe prognozirovanie i hirurgicheskajÁ profilaktika izbytochnogo rubcevanijÁ posle antiglaukomatoznyh operacii: Avtoref. … kand.med.nauk, M., 2000.š— 25 s.

6. Wax M., Barrett D., Pestronk A. Increased incidence of paraproteinemia and autoantibodies in patients with glaucoma //Invest. Ophthalmol.š— 1994.š— Vol. 117.š— P. 561-568.

7. Priglinger S.G., Alge C.S., Kook D., Thiel M., Schumann R., Eibl K. Potential role of tissue transglutaminase in glaucoma filtering surgery // Invest. Ophthalmol. Vis. Sci.š— 2006.š— Vol. 47.š— № 9.š— P. 3835-3845.

8. Hodzhaev N.S., Nersesov YU.Ye., Zahidov A.B. Antiproliferativnyi yÅffekt lokal'noi citokinoterapii v yÅksperimental'noi modeli antiglaukomatoznoi operacii // Fedorovskie chtenijÁš— 2009: nauch.-prakt. konf. s mezhdunar. uchastiem, 8-jÁ: Sb. nauch. st.š— M., 2009.š— S. 225-226.

9. Cvenkel ÷., Kopitar A.N., Ihan A. Inflammatory molecules in aqueous humor and on ocular surface and glaucoma surgery outcome // Mediators Inflamm.š— 2010.š— Vol. 102.š— № 7.š— P. 902-1007.

10. Meyer-Ter-Vehn ô., Grehn F., Schlunck G. Localization of TGF-beta type II receptor and ED-A fibronectin in normal conjunctiva and failed filtering blebs//Mol. Vis.-2008.-Vol. 25.-No. 14.-P. 136-141.

11. Dugina A.E. Osobennosti techenijÁ postoperacionnogo perioda i rol' protivomikrobnyh peptidov i interleikina-17 v ranevom processe pri hirurgicheskom lechenii bol'nyh pervichnoi otkrytougol'noi glaukomoi: Avtoref. … kand.med.nauk, M., 2010.š— 23 s.

12. Erichev V.P., GankovskajÁ L.V., Koval'chuk L.V. i dr. Izmenenie nekotoryh immunologicheskih pokazatelei sleznoi zhidkosti pri izbytochnom rubcevanii posle antiglaukomatoznyh operacii u pacientov s pervichnoi otkrytougol'noi glaukomoi / Vestn. oftal'mol.š— 2010.š— T.126.š— №3.š— S. 25-29.

13. GankovskajÁ L.V., Erichev V.P. CitokinoterapijÁ reparativnyh processov pri antiglaukomatoznyh operacijÁh // Sb. trudov RGMU "Sovremennye problemy allergologii, klinicheskoi immunologii i immunofarmakologii"š— M., 1998.š— S. 756.

14. Tahchidi E.H. Kliniko-patogeneticheskoe obosnovanie mikroinvazivnoi nepronikayushei glubokoi skleryÅktomii v hirurgii pervichnoi otkrytougol'noi glaukomoi: Avtoref. … kand.med.nauk, M., 2008.š— 23 s.

15. Vasilenkova L.V. KorrekcijÁ reparativnyh processov metodom lokal'noi citokinoterapii pri antiglaukomatoznyh operacijÁh: Avtoref. … kand.med.nauk, M., 2005.š— 24 s.


About this article

Authors: Matyuhina E.N., Shevchuk N.E., Babushkin A.E., Orenburkina O.I.

Year: 2015

Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

Crossref
Cyberleninka
Doi
Europeanlibrary
Googleacademy
scienceindex
worldcat
Current issue About edition Editorial board To authors Subscription Our authors Files
¿ üÌÅËÔÒÏÎÎÏÅ ÐÅÒÉÏÄÉÞÅÓËÏÅ ÉÚÄÁÎÉÅ: ÷åóôîéë ïçõ on-line (VESTNIK OSU on-line), ISSN on-line 1814-6465
úÁÒÅÇÉÓÔÒÉÒÏ×ÁÎÏ × æÅÄÅÒÁÌØÎÏÊ ÓÌÕÖÂÅ ÐÏ ÎÁÄÚÏÒÕ × ÓÆÅÒÅ Ó×ÑÚÉ, ÉÎÆÏÒÍÁÃÉÏÎÎÙÈ ÔÅÈÎÏÌÏÇÉÊ É ÍÁÓÓÏ×ÙÈ ËÏÍÍÕÎÉËÁÃÉÊ
ó×ÉÄÅÔÅÌØÓÔ×Ï Ï ÒÅÇÉÓÔÒÁÃÉÉ óíé: üÌ № æó77-37678 ÏÔ 29 ÓÅÎÔÑÂÒÑ 2009 Ç.
õÞÒÅÄÉÔÅÌØ: ïÒÅÎÂÕÒÇÓËÉÊ ÇÏÓÕÄÁÒÓÔ×ÅÎÎÙÊ ÕÎÉ×ÅÒÓÉÔÅÔ (ïçõ)
çÌÁ×ÎÙÊ ÒÅÄÁËÔÏÒ: ó.á. íÉÒÏÛÎÉËÏ×
áÄÒÅÓ ÒÅÄÁËÃÉÉ: 460018, Ç. ïÒÅÎÂÕÒÇ, ÐÒÏÓÐÅËÔ ðÏÂÅÄÙ, Ä. 13, Ë. 2335
ôÅÌ./ÆÁËÓ: (3532)37-27-78 E-mail: vestnik@mail.osu.ru
 1999–2024 ¿ CIT OSU