2015, № 12 (187)

Drozdova E.A., Yadykina E.V. SIGNIFICANCE OF INTRLERLEUKIN-17 IN THE DEVELOPMENT OF UVEITIS IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS (JIA)Uveitis related to JIA account for about 75 % of anterior uveitis in children. Uveitis is hard for the development of complications, which make up 40 % of cases and may lead to a reduction of visual acuity and blindness without treatment. Among the risk factors for uveitis related to JIA an important place is given the role of cytokines. Special attention is now paid as interleukin-17 (IL-17). It is known that the increase in IL-17 is observed in the articular syndrome of JIA, but poorly understood role of IL-17 in the development of uveitis associated with JIA. The study was conducted in the last 7 years. Observed 143 children with a diagnosis of juvenile idiopathic arthritis. Uveitis developed in 63 (44 %). Uveitis developed in 25 boys (39.7 %) and 38 girls (60,3 %). Inflammation in one eye proceeded in 29 patients (40 %): 19 girls (65.5 %) and 10 boys (34.5 %). The process was bilateral in 34 patients (60 %): 19 girls (55.9 %) and 15 boys (44.1 %). To determine the role of IL-17 in children with uveitis associated with JIA in children, we conducted a quantitative analysis of IL-17 in the serum of children suffering from arthritis with no signs of intraocular inflammation, and with diagnosis of "uveitis." A statistically significant increase in levels of IL-17 in patients with uveitis associated with JIA, in relation to the group of patients with JIA without uveitis, and in the control group (p ≤ 0.05). Determination of the concentration of IL-17 in the serum of patients with JIA may be a perspective trend of early diagnosis of uveitis in children with JIA and development new treatments.Key words: juvenile idiopathic arthritis, uveitis, intrlerleukin-17.

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About this article

Authors: Drozdova E.A., Yadykina E.V.

Year: 2015

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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