Duskaev G.K., Drozdova E.A., Alyoshina E.S., Bezryadina A.S.
ESTIMATION OF IMPACT ON THE INTESTINAL MICROFLOR OF BIRDS OF SUBSTANCES WITH ANTIBIOTIC, PROBIOTIC AND ANTI-QUORUM SENSING EFFECTS ^{[№ 11 ' 2017]}
The search for ways to increase the productivity of farm animals has always been one of the most important areas of research. Poultry farming was no exception. The study of new possibilities for using preparations of both synthetic and vegetable origin, consideration of their composition and properties, as well as investigation of the effects exerted by them on the intestinal microflora, will make it possible to avoid possible deplorable consequences for both poultry and human beings. Substances such as probiotic Lactobifadol, Biovit antibiotic and oak bark extract, in various volumes have both an overwhelming and stimulating effect on the intestinal microflora of the bird. Extract of the oak bark had a serious depressing effect on the intestinal biota of the bird. There was an obvious relationship between the increase in the volume of the extract and the degree of suppression of the intestinal microflora. The use of the probiotic Lactobifadol stimulated the quantitative composition of the intestinal microflora of the bird, however, when the probiotic was combined with the oak bark extract, the number of microorganisms in the sample was reduced. The use of antibiotic Biovit contributed to a serious inhibition of the intestinal microbiota of the bird. But when studying the joint action of the drug with the extract of the oak cortex, partial inactivation of the bactericidal effects occurred, as evidenced by higher values of the colony forming units (CFU), relative to the single use of the antibiotic.

Drozdova E.A., Khokhlova D.Yu.
EFFECT OF ANTIHYPERTENSIVE MEDICINES ON THE EFFICACY OF INTRAVITREAL RANIBIZUMAB IN PATIENTS WITH RETINAL VEIN OCCLUSION ^{[№ 12 ' 2015]}
The article is devoted to an actual problem in ophthalmology — treatment of macular edema due to retinal vein occlusion (RVO). Systemic hypertension (SH) is one of systemic risk factors of RVO, and treatment of SH is carried out by different groups of medicines. Purpose: to determine the effect of antihypertensive medicines on the efficacy of intravitreal injection (IVI) of ranibizumab in patients with RVO. We investigated 48 patients with RVO, performed standard and modern methods examination, made of (IVI) ranibizumab according to standard. All patients had SH. 25 patients (52 %) had compensation of SH. Of all patients 16 patients (33 %) took for treatment of SH angiotensin converting enzyme inhibitors (ACE inhibitors), 9 (19 %) — β-blockers and calcium channel blockers. 23 patients (48 %) had decompensation of SH. Mean best-corrected visual acuity increased in patients with compensation blood pressure of ACE inhibitors: 0.5 ± 0.1 in group with nonischemic type and 0.12 ± 0.1 in group with ischemic type, and decrease of macular edema. ACE inhibitors increases the efficacy of IVI ranibizumab. The decompensation of SH may worsen the prognosis of visual functions, which need to be considered prior to IVI of ranibizumab.

Drozdova E.A., Yadykina E.V.
SIGNIFICANCE OF INTRLERLEUKIN-17 IN THE DEVELOPMENT OF UVEITIS IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS (JIA) ^{[№ 12 ' 2015]}
Uveitis related to JIA account for about 75 % of anterior uveitis in children. Uveitis is hard for the development of complications, which make up 40 % of cases and may lead to a reduction of visual acuity and blindness without treatment. Among the risk factors for uveitis related to JIA an important place is given the role of cytokines. Special attention is now paid as interleukin-17 (IL-17). It is known that the increase in IL-17 is observed in the articular syndrome of JIA, but poorly understood role of IL-17 in the development of uveitis associated with JIA. The study was conducted in the last 7 years. Observed 143 children with a diagnosis of juvenile idiopathic arthritis. Uveitis developed in 63 (44 %). Uveitis developed in 25 boys (39.7 %) and 38 girls (60,3 %). Inflammation in one eye proceeded in 29 patients (40 %): 19 girls (65.5 %) and 10 boys (34.5 %). The process was bilateral in 34 patients (60 %): 19 girls (55.9 %) and 15 boys (44.1 %). To determine the role of IL-17 in children with uveitis associated with JIA in children, we conducted a quantitative analysis of IL-17 in the serum of children suffering from arthritis with no signs of intraocular inflammation, and with diagnosis of "uveitis." A statistically significant increase in levels of IL-17 in patients with uveitis associated with JIA, in relation to the group of patients with JIA without uveitis, and in the control group (p ≤ 0.05). Determination of the concentration of IL-17 in the serum of patients with JIA may be a perspective trend of early diagnosis of uveitis in children with JIA and development new treatments.

Аleshina Е.S., Drozdova E.A.
ESTIMATION THE BIOTOXICITY OF CARBON NANOTUBES USEBASEDLUMINESCENT MICROORGANISMS ^{[№ 10 ' 2015]}
Despite the fact that carbon nanomaterials (CNM) was opened thirty years ago, it is still expanding the range of their application, as well as the amount of research devoted to the determination of their biological effects. In the literature, are constantly emerging data about the possible adverse effects caused by the CNM, developing at different levels of the organization alive. Therefore, the study questions the potential risks of their use still seems paramount. A possibility to use for this purpose natural and recombinant strains of luminescent bacteria is very important. In this context, the aim of this work was to evaluate the biological effects of carbon nanomaterials represented 8 samples and includes both single-walled and multi-walled nanotubes and nanofibers, methods of bioluminescence assay using luminescent recombinant Escherichia coli strain K12 TG1 with cloned luxCDABE genes of marine luminous bacteria Photobacterium leiognathi 54D10 marketed in a lyophilized form and natural strains Photobacterium phosphoreum-17 677f (based on commercial test systems "Mikrobiosensor-17 677f"). In experiments on E.coli CNM for compounds dispersed in distilled water, followed by ultrasonic treatment with EC20 and EC50 values were calculated from 5 to 8 CNM. When used as Photobacterium phosphoreum EC20 values were established for 7 of 8, and an EC50 of 5 to 8 CNM. It was found that the natural luminescent strain Photobacterium phosphoreum in 17-677f characterized by severe and rapid response to the impact of CNM than recombinant strain of Escherichia coli K12 TG1. At the same time the details of the response to use the touch-term strains determines they are not mutually exclusive, but complementary use.

Drozdova E.A., Аleshina Е.S.
ANTAGONISTIC ACTIVITY OF STRAINS PROBIOTIC PREPARATIONS AGAINST TEST ORGANISM SALMONELLA ENTERITIDIS AND EFFICIENCY OF THEIR JOINT USE WITH ANTIBIOTICS WAS DETECTED ^{[№ 10 ' 2015]}
The result of the experiments was determined by antibiotic resistance and antagonistic activity of the strains entering into probiotic preparations in respect of the test organism Salmonella enteritidis and their possible combined action with antibiotics. The experiment was set in conditions in vitro. Against the background of antibiotic therapy in the treatment of various infections develop microecological bowel disorders such as dysbiosis. For the treatment of the effects of the most studied direction at the present time is the use of probiotics — biological drugs based on representatives of the normal microflora of man. The feasibility of the simultaneous application of probiotics most used in clinical practice, antibiotics are currently the subject of discussion, as probiotic microorganisms are sensitive to many antimicrobial agents. In this regard, we have conducted the following studies and research to substantiate the effectiveness of the joint application of probiotics based nonsporeforming bacteria with antibiotics in the treatment of Salmonella infection in in vitro.

Drozdova E.A., Khokhlova D.Yu.
DEPENDENCE OF THE EFFICIENCY OF ANTI-ANGIOGENIC THERAPY OF COMPENSATION HYPERTENSION IN PATIENTS WITH RETINAL VEIN OCCLUSION ^{[№ 12 ' 2014]}
The article is devoted to the actual problem in ophthalmology — treatment of macular edema (ME) in patients with retinal vein occlusion (RVO). Leading risk factor for RVO is hypertension (62 %). Objective: To evaluate the efficacy of anti-VEGF therapy, depending on the stage of hypertension and blood pressure (BP). Results: the efficiency of anti-VEGF therapy is increased in blood pressure control in patients with non-ischemic type of occlusion, regardless of the stage of hypertension, which is manifested in the increase in visual acuity (average of 0,29) and a decrease in the height of defense.

Yadykina E.V., Drozdova E.A.
MODERN APPROACHES TO COMPLICATED CATARACT SURGERY IN CHILDREN WITH UVEITIS RELATED TO JUVENILE IDIOPATHIC ARTHRITIS (JIA) ^{[№ 12 ' 2014]}
Asses effiiciencyof the surgery of the uveitis cataract related to Juvenile Idiopathic Arthritis depending on the aphakic correction method. Complicated cataract developed in 15 (22,4 %) patients, 22 eyes. The level of visual acuity with the implantation of IOL is higher than without it (0,52±0,2); the longterm post surgery uveitis process does not depend on the presence of IOL. The secondary glaucoma is often observed when implantation IOL is used.

Drozdova E.A., Karimov I.F.
RUMEN FLUID NORMAL COMPONENTS EFFECTS ON LUMINESCENCE LEVEL OF BIOSENSOR ^{[№ 6 ' 2014]}
The effect of real (native) and rumen fluid mixture model on the emission level of luminescent strain E.coli was considered. Revealed similar toxic effects studied biological fluids, developing in the first minutes of contact. Analyzed the impact of individual components on rumen fluid bacteria glow, as well as the contribution of individual components of the trophic substrate.

Drozdova E.A., Balkin A.S., Rakitina N.P.
ANTIBIOTICS AND PROBIOTICS EFFICIENT JOINT USE DUIRING EXPERIMENTAL INFECTION ^{[№ 10 ' 2013]}
Antagonistic activity of strains probiotic preparations against test organism Salmonella enteritidis and efficiency of their joint use with antibiotics was detected.

Drozdova E.A., Bukharina E.S.
DIAGNOSTIC PECULIARITIES OF ISOLATED AND COMBINED CONTUSIONAL FRACTURES OF ORBITAL MEDIAL WALL ^{[№ 12 ' 2012]}
There were investigated the peculiarities of the clinic and modern diagnostic methods of isolated and combined contusional fractures of orbital medial wall. There were obtained the data supporting the need for early implementation of multispiral computed tomography — research for suspected fracture of the orbit medial wall.

Kondakova K.S., Yapryntseva E.V., Drozdova E.A., Mishchenko N.V.
THE DEPENDENCE OF THE DIGESTIBILITY OF MINERALS AND VEGETATION COMPLEXES ON THE DEGREE OF ADHESION OF MICROORGANISMS TO THE SURFACE OF FOOD PARTICLES ^{[№ 12 ' 2011]}
The survey was developed and tested methodology quantifying microorganisms adhered to feed particles by means of a fluorescence microscope. It is noted that the application of mineral supplementation has an effect on bacterial adhesion to the substrate. Established correlation between the number of adhered micro-organisms and food digestion study of substrates.

Kholodilina T.N., Miroshnikov S.A., Grechushkin A.I., Drozdova E.A., Zinyukhin G.B.
BIOAVAILABILITY OF ASH ELEMENTS FROM EXTRUDECONTAINING RATION ^{[№ 12 ' 2007]}
Effectiveness of extrudates using containing buckwheat husks and phuz-sediment at feeding of ruminant animals is researched in this article. Digestion of organic and ash parts of food are appreciated here. The influence of hot extrusion on bioavailability of chemical elements is revealed in this work.

^{[№ 12 (app.1) ' 2006]}

^{[№ 12 (app.1) ' 2006]}

Drozdova E.A., Varnavskaya N.G., Kutepova I.A.
PECULIARITIES OF CLINICAL COURSE AND APPROACHES TO TREATMENT OF UVEAL GLAUCOMA ^{[№ 13 ' 2004]}