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October 2015, № 10 (185)

Bokov D.A., Neverova P.S., Obidchenko M.P., Senchukova M.A., Shevluk N.N. EXPERIMENTAL MODELING OFTOXIGENIC PATHOLOGYEMBRYOGENESIS: ENVIRONMENTAL ASPECTS Using patented models of experimental gastric cancer on the subacute formaldehyde chronic intoxication background, it has been studied its effect on the laboratory rats' pregnancy and development of the embryo and fetus.The results reveal a disorder of the volume and direction of the histological and organ differentiation process that determines the subsequent animals' stillbirth. Particularly, histological examination has found that stillborn rats have fetal and even embryonic organs. Their lungs werein the saccular stage of development. Cuboidal epithelium of saccules was not changed on squamous one. Strom was presented by only cellular elements, its elastic fiber component wasn't expressed.Formation of adequate alveolar-vascular relations was delayed.These structural factors contribute to the inability to maintain an effective gas exchange.The kidneys of these animals were on the metanephrogenicblastema stage.The digestive tube was at the epithelial plug stage.In the skeleton there were no centers of ossification.The whole complex morphogenetic phenomena allows to prove unviability of newborn rats: a significant proportion of their stillbirths.At the same time, fertility, the possibility of pregnancy and its parameters are suppressed, that resulting in a decrease in weight and number of newborn rats. Long-term intake of subthreshold concentrations of formaldehyde, caused by the accumulation of the substance in hydro- and edafosfere, proves embriotoxic value of xenobiotic and poor prognosis of pregnancy and the end of gestation, considering carcinogenic effects and cancer of the mother's stomach.Key words: embryogenesis, formaldehyde, germ cells, gonads, fertility, developmental disorders.


1. Arshavskiy I. A. Physiological mechanisms and patterns of individual development. — M.: Nauka, 1982. — 270 p.

2. Beletskaya E. N., Onul N. M. The combined effect of lead and zinc in the embryonic development of laboratory rats // Gigienaisanitariya. — 2014. — №6. — P. 55-59.

3. Bokov D. A., Gotskina N. Y., Vdovenko D. V. Destructive and degenerative changes in the laboratory rats' testes in chronic subacute formaldehyde intoxication // VestnikMordovskogouniversiteta. — 2009. — №1. — P. 107-108.

4. Bokov D. A., Demina L. L., Gotskina N. Y. Dynamics of atresia and yellow body of pregnancy in female gonads of wood mouse folliculogenesis in determining the potency of adaptive reproductive activity of organisms // Morfologicheskievedomosti. — 2009. — №3. — S. 276-277.

5. Bokov D. A., Shevlyuk N. N. Characteristic of spermatogenesis in mice CBA Ч C57Bl6 during combined action of chromium and benzene // Problemyreproduktsii. — 2014. — №2. — P. 7-11.

6. Bokov D. A., Shevlyuk N. N., Abdil'danova A. M. Forming variability of cytometric parameters in different clusters of interstitial endocrine cells of the testes of mice CBA Ч C57Bl6 during chrome and benzene intoxication in experiment // Byulleten' eksperimental'noybiologiiimeditsiny. — 2014. — №1. — P. 53-56.

7. Dorogova V. B., Taranenko N. A., Rychagova O. A. Formaldehyde in the environment and its effect on the body (a review) // Byulleten' Vostochno-Sibirskogonauchnogotsentra SO RAMN. — 2010. — №1. — P. 32-35.

8. Zaynalova S. A., Sinchikhin S. P., Stepanyan L. V. Complications of gestation in women living in environmentally disadvantaged areas // IzvestiyaSamarskogonauchnogotsentra RAN. — 2014. — №5(2). — P. 699-701.

9. Zaytseva N. V., Dolgikh O. V., Dianova D. G. Formaldehyde contamination effect on the immune system's parameters in infants // IzvestiyaSamarskogonauchnogotsentra RAN. — 2014. — №5(2). — P. 702-704.

10. Complex report about environmental conditions in Orenburg region in 2013 year.

11. Kotb M. M. Features of the hloridinantimalarials structural analogue's (drug IEM-687) damaging effect at different stages of the white rats' embryogenesis. // Archivanatomii, gistologiiiembriologii.– 1972. — №8. — P. 88-96.

12. Nikolaeva E. A., Bokov D. A., Shurygina E. I. Low-intensity formaldehyde intoxication in the induction of ovarian neoplasia pregnant female laboratory rats// Vestnik RGMU. — 2010. — №2. — P. 279-280.

13. The patent for the invention №2401463. The method of modeling the experimental gastric cancer. Authors: Senchukova M. A., Stadnikov A. A., Kozlov A. V., Bokov D. A.

14. Taranenko N. A., Efimova N. V. Biomonitoring of formaldehyde in the urine samples of the child population of the Irkutsk region // Gigienaisanitariya. — 2007. — №4. — P. 73-75.

About this article

Authors: Shevlyuk N.N., Bokov D.A., Neverova P.S., Obidchenko M.P., Senchukova M.A.

Year: 2015

Sergey Aleksandrovich

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