Vestnik On-line
Orenburg State University march 29, 2024   RU/EN
Headings of Vestnik
Pedagogics
Psychology
Other

Search
Vak
Антиплагиат
Orcid
Viniti
ЭБС Лань
Rsl
Лицензия Creative Commons

2013, № 4 (153)



Trunov A.N., Arbeneva N.C., Gorbenko О.М., Shvayuk А.P., Obukhova O.O. IMBALANCE CYTOKINES IN THE TEAR FLUID IN PATIENTS WITH AUTOIMMUNE UVEITISStudy activity the local immunoinflammatory process in patients with autoimmune uveitis. We examined 60 patients with autoimmune uveitis (study group) not receiving basic treatment system autoimmune disease and 20 control patients. In the lacrimal fluid of patients before treatment, by enzyme immunoassay, was conducted determination of IL-17A, IL-8, IL-6, IL-4. Found that in the pathogenesis of uveitis associated with systemic autoimmune diseases, an important role is the development of local immunoinflammatory process, which is manifested in a significant increase in tear fluid of surveyed patients, concentrations of proinflammatory cytokines IL-17A, IL-8, that accompanied by increased concentrations of IL-4, IL-6, which play a significant role in the development of autoimmune response and chronic inflammatory processes in their relationship, which was confirmed data correlation analysisKey words: autoimmune uveitis, сytokines immunoinflammatory process.

Download
References:

1. Drozdov E.A. Uveitis in rheumatic diseases: clinical features, diagnosis, immunopathogenesis and treatment: Author. dis.... doctor of medicine. M., 2006. — 41p.

2. Katargina L.A., Starikov A.V., Denisov E. Efficacy of Remicade in the treatment of uveitis associated with diseases of the joints, in children / / Rus. ped. Ophthalmology. — 2009. — №4. -P. 13-17.

3. Chernykh V.V., Egorova E.V., Ermakova O.V., Trunov A.N., Bethke A.N., Obukhova O.O. A possible role immune disorders in the pathogenesis of pseudoexfoliation syndrome / / Bull. RAMS. — 2009. — №4. -P. 131-135.

4. Chernykh V.V., Khodzhaev N.S., Tahchidi E.H., Gorbenko O.M., Shvayuk A.P. Obukhov O.O., Trunov A.N. Pathogenesis initial stage of primary open-angle glaucoma, the importance of immunoinflammatory processes / / Ophthalmosurgery. -2011. — №2. -P. 50-53.

5. Barisani-Asenbauer T., Maca S.M., Mejdoubi L., Emminger W., Machold K., Auer H. Uveitis– a rare disease often associated with systemic diseases and infections– a systematic review of 2619 patients// Orphanet Journal of Rare Diseases -2012.-Vol7, №1.Р.57.(http://www.ojrd.com/content/7/1/57)

6. Commodaro A. G., Bueno V., Belfort R. Jr., Rizzo L. V. Autoimmune uveitis: the associated proinflammatory molecules and the search for immunoregulation // Autoimmun. Rev.– 2011.– Vol. 10, №4. -Р. 205–209.

7. Chen H. T., Wang H., Zhao M., Hou B. Regulation of antigen specific Th17 cells differentiation in experimental autoimmune uveitis // Zhonghua Yan KeZaZhi. -2012.– Vol. 48, №3.– Р. 234–240.

8. Horai R., Caspi R. R. Cytokines in autoimmune uveitis // J. Interferon Cytokine Res.– 2011. -Vol. 31, №10. — P. 734–744.

9. Hohki S., Ohguro N., Haruta H., Nakai K., Terabe F., Serada S., Fujimoto M., Nomura S., Kawahata H., Kishimoto T., Naka T. Blockade of interleukin-6 signaling suppresses experimental autoimmune uveoretinitis by the inhibition of inflammatory Th17 responses // Exp. Eye. Res.– 2010. -Vol. 91, №2. -Р. 162–170.

10. Kang M. H., Kim M. K., Lee H. J., Lee H. I., Wee W. R., Lee J. H. Interleukin-17 in various ocular surface inflammatory diseases // J. Korean Med. Sci. -2011.– Vol. 26, №7.– P. 938–944.

11. Mohsenin A., Huang J.J. Ocular manifestations of systemic inflammatory diseases// Conn. Med. -2012.-Vol.76, №9.-Р.533-544.


About this article

Authors: Arbenyeva N.S., Gorbenko O.M., Obuhova O.O., Shvayuk A.P., Trunov A.N.

Year: 2013


Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

Crossref
Cyberleninka
Doi
Europeanlibrary
Googleacademy
scienceindex
worldcat
© Электронное периодическое издание: ВЕСТНИК ОГУ on-line (VESTNIK OSU on-line), ISSN on-line 1814-6465
Зарегистрировано в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций
Свидетельство о регистрации СМИ: Эл № ФС77-37678 от 29 сентября 2009 г.
Учредитель: Оренбургский государственный университет (ОГУ)
Главный редактор: С.А. Мирошников
Адрес редакции: 460018, г. Оренбург, проспект Победы, д. 13, к. 2335
Тел./факс: (3532)37-27-78 E-mail: vestnik@mail.osu.ru
1999–2024 © CIT OSU