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2015, № 12 (187)



Tereshchenko A.V., Belyy Yu.A., Takhchidi E.Kh., Novikov S.V., Maychuk N.In., Usanova, G.Yu. EXPERIMENTAL STUDY OF THE EFFECT OF A 0.1 % SOLUTION OF BENZALKONIUM CHLORIDE ON THE CONDITION OF THE CORNEA IN RABBITSIn order to create an experimental model of toxic corneal erosion in rabbits we have studied clinical and functional condition of the cornea (with use of confocal microscopy and quantitative calculation of the area of desquamated epithelium) and comparative assessment of the effect by instillation surface-active 0.1 % solution of benzalkonium chloride (experimental group) four times a day for 7 days, and saline solution (control group) on the rabbit cornea. It was shown that instillation of 0.1 % benzalkonium chloride for 7 days induced toxic corneal erosion, which is perspective for further development of new methods for treatment and prevention of this nosology.Key words: benzalkonium chloride, corneal erosion, cytotoxicity, confocal microscopy.

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About this article

Authors: Maychuk N.V., Tahchidi E.H., Usanova G.Yu., Tereshchenko A.V., Belyy Yu.A., Novikov S.V.

Year: 2015


Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

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