Vestnik On-line
Orenburg State University december 23, 2024   RU/EN
Headings of Vestnik
Pedagogics
Psychology
Other

Search
Vak
Антиплагиат
Orcid
Viniti
ЭБС Лань
Rsl
Лицензия Creative Commons

2014, № 6 (167)



Valeyeva L.A., Kulagina I.G., Yafayeva E.G. THE EFFECT OF DIAZEPAM ON MOTION ACTIVITY OF RATS DEPENDING ON THE CIRCADIAN TIME AND DENSITY OF CEREBRAL GABA RECEPTORSThe effect of diazepam on motion activity in rats after morning and evening introduction has been studied. It has been found that maximal suppressing effect of the medecation on the motion coefficient in a test "open area" is observed after evening introduction at the highest density of cerebral GABA receptors. After morning injection the suppressing effect is observed twice, i.e. immediately after the injection and during evening hours against the background of receptor increase.Key words: motion coefficient, diazepam, chronobiological organization, GABA-receptors, brain

Download
References:

1. Arushunyan E. B. Chronobiological peculiarities of neurotic disturbances and anxiolytic effect of psychotropic preparation // Russian psychiatry Journal. 2000. No.1. — P.27-32.

2. Arushunyan E. B., Beyer E. B. Chronobiological peculiarities of antistress effect of anxiolytic preparation // Experimental and clinical pharmacology. 1998. Vol.61. No.6. — Р.13– 16.

3. Atroshenko O. N., Losev A.S., Sadykov R.F. et al. Effect of bemethyl, ethomerzole and thienazole on the individual mice behaviour // Public health of Bashkortostan. 1999. No.2. — P.53-58.

4. Biological membrane / edited by J. Findley and Ewans World. 1990. — 444 pp.

5. Voronina T.A., Molodavkin G. M., Babayev I.I., Smirnov L.D. Study of antistress and analgetic effect of mexidol diazepam paracetamole and combinations // Experimental and clinical pharmacology. 2006. Vol.69. No.4. — P.6-9.

6. Erdakov L.N. Organization of rhythms of rodents activity. Novosibirsk. — 1984. 115 pp.

7. Zinovyeva V.A., Katushkina E.A., Mozolevskiy Yu. B., Podlubnaya Z.A., Vikhlyantsev I.M., Yakhno N.N. Syndrome of a rigid persone: pathogenesis and treatment // The Journal of Neurology. 2009. Vol.14. No.1. — P.11-17.

8. Kozhechkin S.N. Comparative electroencephalographic assessment of anxiolytics acephabole and diazepam on in-bred rats of MR and MNRA lines with various level of anxiety lighting // Experimental and clinical pharmacology. 2003. Vol. 66. No.2. — P.38-15.

9. Komarov F.I., Rapoport S.I. Chronobiology and chronomedicine. Moscow: Triada-X, 2000. — 488 рр.

10. Manvelyan E.A., Baturin V.A. Sex differenсe in the action of diazepam in rats in conflict situation test // Experimental and clinical pharmacology. 2008. Vol.71. No.4. — P.11-13.

11. Mezentsev V.E., Larionov L.P. The dependence of pharmacological effect of neuro– and psychotropic medications on the state of temporary receptors organization: Fundamental research as the basis for development of medicinal preparations: Collection of abstracts of the 1st Congress of Russian Scientific Society of Pharmacologist. Volgograd. 9-13 October, 1995. — M., 1995. — 274 pp.

12. Rebrova О.Yu. Statistic analysis of medical data Application of a package of applied STATISTICA programs. M.: Mediasphere, 2002. — 312 рp.

13. Tyurenkov I.N., Perfilova V.N. Role of GABA-receptors in the development of pathological processes // Experimental and clinical pharmacology. 2011. Vol.74. No.2. — P.47– 52.

14. Agle M.W., Dunn M.N. Kinetics of [3H]-muscimol binding to the GABAA–receptor in bovine brain membrane // Biochemistry. 1989. Vol.28. — P.275-285.

15. Flaishon R., Halpern P., Sorkine P. [et al.] Cross-sensitivity between isoflurane and diazepam: Evidence from a bidirectional tolerance study in mice // Brain Res. 1999. Vol.815. No.2. — Р.287–293.

16. Grandison L., Cavagnini F., Schmid R. Aminobutiric acid and benzodiasepine — binding sites in human anterior pituitary tissue // Endocrinol. And metabol. 1982. Vol.54. No.3. — P.597-601.

17. Gusev A.G., Swadlow H. А. The impact of "bursting" thalamic impulses at a neocortical synapse // Nature Neurosci. 2001. Vol. 4. No.4. — Р.402 — 408.

18. Gelatti U., Samani F., Donato F., Covolo L., Mazzaglia G., Cremaschini F., Simon G.. Leggieri G., Balestrieri M. Health-related quality of life in older people using benzo-diazepines: A cross-sectional study // Ann.ig.:Med prev e comunita. 2006. Vol.18. No.4. — P. 313-326.

19. Lowry O.H., Rosenbrough N.J., Farr L. [et al.] Protein meagument with Folin phenol reagent // J.Вiol.Chem. 1951. Vol.193. No.1. — Р. 265-275.

20. Shyder S.H., Enna S.J. Properties of?-aminobutyris asid (GABA) receptor binding in rat brain synaptic membrane fractions // Mol. Pharmacol. 1977. Vol.13. — P. 442-453.

21. Vekovischeva Olga, Uusi-Oukari Mikko, Korpi Esa R. Tolerance to diazepam-induced motor impairment. A study with GABAa receptor?6 subunit knockout mice // Neurochem. Res. 2003. Vol.28. No.5. — P. 757-764.


About this article

Authors: Valeeva L.A., Yafaeva E.G., Kulagina I.G.

Year: 2014


Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

Crossref
Cyberleninka
Doi
Europeanlibrary
Googleacademy
scienceindex
worldcat
© Электронное периодическое издание: ВЕСТНИК ОГУ on-line (VESTNIK OSU on-line), ISSN on-line 1814-6465
Зарегистрировано в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций
Свидетельство о регистрации СМИ: Эл № ФС77-37678 от 29 сентября 2009 г.
Учредитель: Оренбургский государственный университет (ОГУ)
Главный редактор: С.А. Мирошников
Адрес редакции: 460018, г. Оренбург, проспект Победы, д. 13, к. 2335
Тел./факс: (3532)37-27-78 E-mail: vestnik@mail.osu.ru
1999–2024 © CIT OSU