2012, № 6 (142)

Tinkov A.A., Rogachova M.N., Nikonorov A.A. CHRONIC CONSUMPTION OF IRON AND COPPER SALTS WITH DRINKING WATER INDUCES OXIDATIVE DAMAGE OF SERUM PROTEINS AND LIPIDSIn the current experiment on female Wistar rats the influence of inorganic salts of Fe and Cu on intensity of free radical oxidation was studied. It is shown that consumption of Fe and Cu with drinking water in doses which exceed maximum permissible concentration 2– and 4-fold for three months induces free radical oxidation processes leading to cumulation of lipid peroxidation (TBARS) and protein oxidation (carbonyls and fluorescent amino acids) products. It is estimated that prooxidant action of isolated iron salts is more potent than in case of copper salts, while the combined consumption of copper and iron is more effective in inducing free radical oxidation than isolated metals.Key words: iron, cooper, free-radical oxidation.

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About this article

Authors: Rogacheva M.N., Tinkov A.A., Nikonorov A.A.

Year: 2012

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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