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Ushakova Yu.V., Kulagina E.P., Chepasov V.I. DETERMINATION OF IGF-1 AND LEPTIN IN BLOOD SERUM OF PATIENTS WITH PANCREATIC DIABETES AND DIABETIC NEPHROPATHY AND DEVELOPMENT OF METHODS FOR IDENTIFICATION OF GROUPS OF PATIENTS WITH DN Target of examination was study of level of serum IGF-1 and leptin of patients with diabetic nephropathy (DN) and development of the methods which would allow to prognose rates of IGF-1 and leptin of children with DN and identify the group of patients with unknown pathology. 24 children 3-18 years aged (average age 14,78 years{95% DN: 13,52-16,04}) have been examined. Clinico-laboratory figures, rates of concentration of IGF-1 and leptin in blood serum have been valuated. They used multivariate statistics methods (correlation analysis, factor analysis and regression analysis) to detect patterns of relationship between main rates of the examined group. As to children with DN, their serum IGF-1 concentration is determined by the age of a patient at the moment of investigation; index of interlobar renal arteries pulsation; decrease of passing rate of radiopharmaceutical through bloodstream by left kidney; time of getting maximum in left kidney. The level of serum leptin of children belonging to the investigated group is characterized by a relative insulin dose of short effect.
About this article
Authors: Ushakova Yu.V., Kulagina E.P., Chepasov V.I.
Year: 2009
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Editor-in-chief |
Sergey Aleksandrovich
MIROSHNIKOV |
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