Sokratov N.V.
PATHOGENETIC MECHANISMS OF CHANGES OF HEMOSTASIS SYSTEM AT DISEASES OF KIDNEYS (REVIEW OF THE LITERATURE) ^{[№ 4 ' 2005]}
The analyses of literature and own researches have allowed to reveal new mechanisms of infringements of hemostasis system at various kidneys diseases. It is shown, that at a pathology of kidneys the change in hemocoagulation system is necessary to examine as transformation of stationary levels of coagulating and anti-coagulating link, and not only as hyper -or hypo hemocoagulating according to concept of DVS-syndrome. At kidneys diseases there is no coagulopathy of consumption, characteristic for the DVS-syndrome, and therefore heparine and fibrinolytics used at treatment of greenstones are not very effective. Therapy of nephritis with glucocorticoids does not give desirable result because it causes acceleration of local system of hemostasis of kidneys. The therapeutic effect is received at prescription of plasmas with high contents of АТ-III which strengthens allocation from ill kidneys of fraction S3-complement, i.e. showingcytoprotective action, and also phentolamine and prodectine, reducing emission in local and general bloodstream active prothrombinase and inactivating kallikrein.