Mushkova I.A., Borsenok S.A., Karimova A.N., Shkandina Y.V.
HISTOMORPHOLOGICAL CHANGES IN THE RABBIT CORNEA AFTER IMPLANTATION INTRACORNEAL LENSES AND ELECTRON MICROSCOPIC JUSTIFICATION OF THE RESULTS ^{[№ 12 ' 2015]}
Today on the international market is approved and available for clinical use different models of intracorneal lenses for surgical correction of presbyopia. Using the technical capabilities and production capacity of domestic manufacturers were modeled and manufactured lenses with geometric parameters, calculated using mathematical modeling taking into account characteristics of the cornea, made of modern polymeric materials. To study the biocompatibility of intracorneal lenses it is necessary to conduct preclinical studies of reactivity of cornea in response to the implantation of the developed products hydroxyethylmethacrylate (HEMA) and olygourethanmethacrylate (OUMA) in an experimental study in vivo and conduction electron-microscopic examination of intact "inlays". When carrying out scanning electron microscopy the surface and edges of intact lenses is rendered smooth surface with no visible chipping. In the study of the shape of the edge surface of intracorneal lenses from HEMA visualized jagged, irregular edge, and lenses from OUMA — smooth, with no visible chipping. When conducting in vivo confocal microscopy in the experimental groups was visualized single collagen fibers, activation of keratocytes, was determined hyperreflexivity and hypocellularity in the area of the lens, pseudokeratinization of the surface epithelium. In the group with the use of GEMA's lenses noted decrease of transparency of the extracellular matrix around the implant. During the light microscope in the experimental groups was visualized bed of inlay. Around bed in both groups was detected activation of cells, presumably native keratocytes. The epithelium and endothelium — no visible changes in the area of inlay and outside this zone. In the control group — no significant changes in all layers of the cornea. Thus, in the course of the study it was found that the developed products do not cause pronounced cellular and tissue response of the cornea of the rabbit, the rendered methods of in vivo confocal microscopy and the light microscopy. However, jagged, irregular shape of the edge surface of GEMA's lenses caused, apparently, more technically complicated manufacturing technology ("turning") can cause greater activation of cells around the bed of the cornea and a moderate seal of stroma around the lens, in comparison with OUMA's lenses.

Mushkova I.A., Semenov A.D., Sobolev N.P., Zakharova I.A., Karimova A.N., Maychuk N.V.
EVALUATION OF RESULTS FOR INDUCED AMETROPY REFRACTIVE CORRECTION IN PATIENTS AFTER RECONSTRUCTIVE SURGERY WITH IMPLANTATION IRIS-LENS DIAPHRAGM ^{[№ 12 ' 2014]}
The research is aimed to develop a diagnostic and treatment algorithm of choice kerato-refractive surgery after reconstructive surgery with implantation iris-lens diaphragm and evaluate the results of induced ametropy correction. We observed 41 eyes (41 patients) with residual ametropy after reconstructive surgery with implantation iris-lens diaphragm before and after keratorefractive operations. The developed algorithm of choice in patients with induced ametropy after reconstructive surgery with implantation iris-lens diaphragm, taking into account the data pachymetry, the localization of the scar and the state of anterior surface of the cornea, provides personalized comprehensive approach in determining the techniques of laser keratorefractive correction that allowed increasing uncorrected visual acuity in all cases. FemtoLASIK — effective and safe technologies allowing obtain high functional results in the correction of induced ametropia in patients after the reconstructive surgery with implantation iris-lens diaphragm.

Mushkova I.A., Kishkin Yu.I., Takhchidi N.Kh.
COMPARATIVE ANALYSIS OF OPHTHALMO-ERGONOMIC DATA AFTER FEMTOSECOND LASER-ASSISTED FEMTO-LASIK AND FEMTO-VISUM ^{[№ 4 ' 2013]}
Comparative analysis ophthalmo-ergonomic data after femtosecond laser-assisted Femto-LASIK and FemtoVisum did not reveal differences. Contrast sensitivity under photopic conditions after both types of surgery recovered to preoperative values.Contrast sensitivity under mesopic conditions after both types of surgeries did not recover to preoperative values.

Semenov A.D., Mushkova I.A., Karimova A.N.
COMPARATIVE EVALUATION OF THE RESULTS OF POSTKERATOPLASTY AMETROPY LASER CORRECTION ^{[№ 4 ' 2013]}
We observed and operated 29 patients with residual ametropy after penetrating keratoplasty: by FemtoLASIK technology — 11 eyes, by standard LASIK technology — 18 eyes. There was received an increase of uncorrected visual acuity from 0,12±0,1 to 0,51±0,23 and from 0,11±0,1 to 0,5±0,24, respectively. Comparative analysis of the results of laser correction showed that corneal flap formed by a femtosecond laser, is more uniformity and less deviation in thickness than a flap formed by microkeratome.