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Тиньков А.А.
Tinkov A.A., Nikonorov A.A.
INFLUENCE OF IRON AND COPPER CONSUMPTION ON ADIPOGENESIS AND ATHEROGENESIS INITIATION IN WISTAR RATS
The aim of the current study was investigation of the iron and copper consumption of the adipogenic effect of the high-fat diet and development of atherogenic changes of the lipoprotein profile in Wistar rats. It has been shown that Fe2+ and Cu2+ consumption potentiates the adipogenic effect of the high-fat diet as assessed by absolute and relative adipose tissue content in the rats' organism. It has been estimated that ecologically-relevant doses of iron and copper induce atherogenic changes in the serum lipoprotein spectra in the experimental animals.
Key words: iron, copper, high-fat diet, atherogenesis, adipogenesis.
Tinkov A.A., Rogachova M.N., Nikonorov A.A.
CHRONIC CONSUMPTION OF IRON AND COPPER SALTS WITH DRINKING WATER INDUCES OXIDATIVE DAMAGE OF SERUM PROTEINS AND LIPIDS
In the current experiment on female Wistar rats the influence of inorganic salts of Fe and Cu on intensity of free radical oxidation was studied. It is shown that consumption of Fe and Cu with drinking water in doses which exceed maximum permissible concentration 2– and 4-fold for three months induces free radical oxidation processes leading to cumulation of lipid peroxidation (TBARS) and protein oxidation (carbonyls and fluorescent amino acids) products. It is estimated that prooxidant action of isolated iron salts is more potent than in case of copper salts, while the combined consumption of copper and iron is more effective in inducing free radical oxidation than isolated metals.
Key words: iron, cooper, free-radical oxidation.
Alekhina E.M., Zakharova O.V., Tinkov A.A., Bogatov M.A., Sharapova N.V., Krasikov S.I.
INFLUENCE OF CHEMICAL FACTORS OF ENVIRONMENT ON ACTIVITY OF SUPEROXIDE SCAVENGERS AND CATALASES OF ORENBURG REGION POPULATION
Popova R.F., Tynkov А.А., Rogacheva М.N.
QUANTITATIVE INDICATORS FOR DORSAL ROOTS OF THE INFERIOR CERVICAL, THORACIC AND LUMBAR SPINAL NERVES
The aim of the work is to obtain morphometric characteristics of dorsal roots of the inferior cervical, thoracic and lumbar spinal nerves. The segmental change to various parameters of dorsal roots of spinal nerves was described. The data obtained might be used in applied medicine.
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Editor-in-chief |
Sergey Aleksandrovich
MIROSHNIKOV |
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