Vestnik On-line
Orenburg State University november 23, 2024   RU/EN
Headings of Vestnik
Pedagogics
Psychology
Other

Search
Vak
Антиплагиат
Orcid
Viniti
ЭБС Лань
Rsl
Лицензия Creative Commons

2013, № 12 (161)



Tinkov A.A., Nikonorov A.A. INFLUENCE OF IRON AND COPPER CONSUMPTION ON ADIPOGENESIS AND ATHEROGENESIS INITIATION IN WISTAR RATSThe aim of the current study was investigation of the iron and copper consumption of the adipogenic effect of the high-fat diet and development of atherogenic changes of the lipoprotein profile in Wistar rats. It has been shown that Fe2+ and Cu2+ consumption potentiates the adipogenic effect of the high-fat diet as assessed by absolute and relative adipose tissue content in the rats' organism. It has been estimated that ecologically-relevant doses of iron and copper induce atherogenic changes in the serum lipoprotein spectra in the experimental animals.Key words: iron, copper, high-fat diet, atherogenesis, adipogenesis.

Download
References:

1. Meerson F.Z., Tverdokhlib V.P., Nikonorov A.A., Filippov V.K., Frolov B.A. The role of suppression of cholesterol 7-hydroxylase activity of the liver in the development of atherogenic stress-induced dyslipoproteinemia. Kardiologiia. 1988;28(9):85-87.

2. Baillie-Hamilton PF. Chemical toxins: a hypothesis to explain the global obesity epidemic. J. Altern. Complement. Med. 2002; 8: 185-192

3. Gaenzer H., Marschang P., Sturm W., Neumayr G., Vogel W., Patsch J., Weiss G. Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol. 2002; 40(12):2189-94.

4. Graham R.M., Chua A.C., Carter K.W., Delima R.D., Johnstone D., Herbison C.E., Firth M.J., O'Leary R., Milward E.A., Olynyk J.K., Trinder D. Hepatic iron loading in mice increases cholesterol biosynthesis. Hepatology, 2010; 52(2):462-71.

5. Ohguchi S., Ichimiya H., Yagi A., Hayashi H., Sakamoto N. Copper-induced hypercholesterolemia of golden hamsters: enhanced synthesis of cholesterol in the liver. Gastroenterol Jpn. 1988; 23(6):629-32.

6. Valko M., Morris H., Kronin MTD: Metals, toxicity and oxidative stress. Curr Med Chem. 2005; 12(10):1161-1208

7. Yuan X.M., Li W. The iron hypothesis of atherosclerosis and its clinical impact. Ann Med. 2003; 35(8):578-91.


About this article

Authors: Tinkov A.A., Nikonorov A.A.

Year: 2013


Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

Crossref
Cyberleninka
Doi
Europeanlibrary
Googleacademy
scienceindex
worldcat
© Электронное периодическое издание: ВЕСТНИК ОГУ on-line (VESTNIK OSU on-line), ISSN on-line 1814-6465
Зарегистрировано в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций
Свидетельство о регистрации СМИ: Эл № ФС77-37678 от 29 сентября 2009 г.
Учредитель: Оренбургский государственный университет (ОГУ)
Главный редактор: С.А. Мирошников
Адрес редакции: 460018, г. Оренбург, проспект Победы, д. 13, к. 2335
Тел./факс: (3532)37-27-78 E-mail: vestnik@mail.osu.ru
1999–2024 © CIT OSU