October 2017, № 9 (209), pages 82–84

doi: 10.25198/1814-6457-209-82

Pashkova T.M. CHARACTERISTICS OF ANTI-CYTOKINE ACTIVITY OF ENTEROCOCCUS SPP., ISOLATED FROM ANIMALSEnterococcus spp. are typical synanthropic microorganisms that, during evolution, have adapted well to survival in a macroorganism, including through the ability to inactivate the factors of innate immunity. Possessing the factors of persistence, the bacteria of the genus Enterococcus can act as the etiological factor of endogenous infectious and inflammatory diseases of animals that arise against the background of a decrease in the natural resistance of the macroorganism. A number of studies have been devoted to the characterization of the persistent properties of Enterococcus spp. of various origin, but certain properties of Enterococcus spp., in particular, anticytokine activity, have not yet been characterized.
In this regard, the anti-cytokine activity of microorganisms of the genus Enterococcus isolated from healthy and infectious-inflammatory diseases (acute and chronic endometritis, mastitis, soft tissue abscesses) in agricultural animals has been studied and the high prevalence of the trait is shown. A higher level of anti-cytokine activity against IL-4 and IL-8 was detected in Enterococcus spp. isolates isolated from infectious inflammatory diseases in comparison with strains isolated from the intestines of healthy animals. Expression of anti-cytokine activity in clinical enterococci was 1.5–1.7 times higher than in intestinal isolates (p < 0.05). Data on the high level of anti-cytokine activity in clinical isolates Enterococcus spp. in comparison with intestinal ones testify to the possible influence of their exometabolites on the local cytokine balance, which supports the inflammatory process.
Thus, the results obtained on the modification of Enterococcus spp. of different origin of cytokine dynamics can be used to differentiate pathogenic strains of Enterococcus spp.Key words: Enterococcus spp., anti-cytokine activity, agricultural animals, intestinal microflora, infectious-inflammatory diseases.

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About this article

Author: Pashkova T.M.

Year: 2017

doi: 10.25198/1814-6457-209-82

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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