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November 2015, № 13 (188)

Davydova О.К. ASPECTS OF PRACTICAL USE OF ALKYLRESORCINOLS BIOLOGICAL PROPERTIESThe problem of identification of organism adaptation mechanisms to extreme influences in most cases includes questions of influence of oxidizing stress, therefore a search of antioxidants of a plant and microbic origin, and also development of the concept of nonspecific mechanisms of a cellprotection against active forms of oxygen becomes still more actual. In the work discussion of various biological effects of alkylresorcinol (AR) allowing to use them for development of biomedical technologies and preparations, and also own experimental studies of antioxidant activity of AR in in vitro, in vivo and in silico models of an oxidizing stress which allowed to range differing with length and an arrangement of the alkylradical of AR, to receive an assessment of their direct effects in system of superoxide-anion generation, influences on change of topological properties of molecules of DNA, and also a contribution to modulation of the damaging effect of active forms of oxygen on a cell is presented. The received results were used when receiving on the basis of AR the liposomalstructures by various methods, their sizes investigation, stability in various storage conditions, encapsulation potential by the example of introduction of a fluorescent probe and an additional antioxidant  — α-tocopherol, and also cytotoxicity estimationby the example of cellular test systems. Taking into account the obtained data about ARbiological activities, scientifically based approaches for creation on their basis cosmeceutical composition for protection of skin against extreme influences are offered.Key words: alkylresorcinol, antioxidant effect, reactive oxygen species, DNA damage, liposomal structures, cytotoxicity evaluation.


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About this article

Author: Davydova O.K.

Year: 2015

Sergey Aleksandrovich

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