Vestnik On-line
Orenburg State University december 08, 2021   RU/EN
Headings of Vestnik
Pedagogics
Psychology
Other

Search
Vak
Антиплагиат
Orcid
Viniti
ЭБС Лань
Rsl
Лицензия Creative Commons

November 2015, № 13 (188)



Davydova О.К. ASPECTS OF PRACTICAL USE OF ALKYLRESORCINOLS BIOLOGICAL PROPERTIESThe problem of identification of organism adaptation mechanisms to extreme influences in most cases includes questions of influence of oxidizing stress, therefore a search of antioxidants of a plant and microbic origin, and also development of the concept of nonspecific mechanisms of a cellprotection against active forms of oxygen becomes still more actual. In the work discussion of various biological effects of alkylresorcinol (AR) allowing to use them for development of biomedical technologies and preparations, and also own experimental studies of antioxidant activity of AR in in vitro, in vivo and in silico models of an oxidizing stress which allowed to range differing with length and an arrangement of the alkylradical of AR, to receive an assessment of their direct effects in system of superoxide-anion generation, influences on change of topological properties of molecules of DNA, and also a contribution to modulation of the damaging effect of active forms of oxygen on a cell is presented. The received results were used when receiving on the basis of AR the liposomalstructures by various methods, their sizes investigation, stability in various storage conditions, encapsulation potential by the example of introduction of a fluorescent probe and an additional antioxidant  — α-tocopherol, and also cytotoxicity estimationby the example of cellular test systems. Taking into account the obtained data about ARbiological activities, scientifically based approaches for creation on their basis cosmeceutical composition for protection of skin against extreme influences are offered.Key words: alkylresorcinol, antioxidant effect, reactive oxygen species, DNA damage, liposomal structures, cytotoxicity evaluation.

Download
References:

1. Anderson, H.H., David, N.A., Leake, C.D. Oral toxicity of certain alkylresorcinols in guinea pigs and rabbits //Proc.Soc.Exp.Biol.Med.  — 1931.  — Vol. 28. –P. 609  — 612.

2. Stasiuk M., Kozubek A. Biological activity of phenolic lipids //Cell. Mol. Life Sci.  — 2010. –Vol. 67. –P. 841–860.

3. El-Registan G.I., Mulyukin A.L., Nikolaev Yu.A., Galchenko V.F., Suzina N.E., Duda V.I. Adaptogenic functions of extracellular autoregulators of microorganisms// Microbiology.  — 2006. –Vol. 75.  — №4.  — P. 380-389.

4. Bespalov M.M., Loiko N.G., Doroshenko E.V., Mulyukin A.L., Kozlova A.N., El-Registan G.I., Kolpakov A.I., Varlamova E.A., Kurganov B.I. The role of microbial dormancy autoinducers in metabolism blockade// Microbiology.  — 2000.  — №2.  — С. 217–223.

5. NikolaevYu.A., El-Registan G.I. A method for producing a biologically active component for the composition for skin care, and the component obtained in this manner. Patent RU №2440096 20.03.2011.

6. Galchenko V.F., Gernet M.V., Golovleva L.A., Deryabin D.G., Kalinin M.V., Loiko N.G., Martirosova E.I., Nikolaev Y.A.,Solyanikova I.P., Shanenko E.F., El-Registan G.I. A method of directional changes in the activity of enzyme proteins. Patent RU№2441068 27.01.2012.

7. Deryabin D.G., Romanenko N.A., El-Registan G.I. A method for stabilizing the antibody in aqueous solutions. Patent RU№2447448 10.04.2012.

8. Kanda N., Ishizaki N., Inoue N., Oshima M., Handa A. DB-2073, a new alkylresorcinol antibiotic. I. Taxonomy, isolation and characterization //J Antibiot (Tokyo).  — 1975.  — Vol. 28(12).  — P. 935-42.

9. Nikolaev Y.A., Borzenkov I.A., Kalinin M.V., Loiko N.G., Tarasov A.L., Plakunov V.K., Belyaev S.S., Voronina N.V., Galchenko V.F., El-Registan G.I.Antimicrobic features of phenolic lipids // Applied Biochemistry and Microbiology. — 2010.  — Vol.46.  — №2.  — P. 159-165.

10. Stepanenko I.Yu., Nikolaev Yu.A., Mulyukin A.L., Kozlova A.N., El'-Registan G.I., Strakhovskaya M.G., Belenikina N.S., Revina A.A.Protection of Saccharomyces cerevisiae against oxidative and radiation-caused damage by alkylhydroxybenzenes // Microbiology.  — 2004. —Vol. 73. — №2. —P. 163-169.

11. Davydova O.K., Deryabin D.G., El-Registan G.I. Influence of Chemical Analogues of Microbial Autoregulators on the Sensitivity of DNA to UV Radiation // Microbiology.  — 2006.  — Vol. 75.  — №5.  — Р. 654–661.

12. Deryabin D.G., Davydova O.K. A process for preparing supramolecular composites. Patent RU №2293766 20.02.2007.

13. Deryabin D.G., Davydova O.K. Gryazeva I.V. A method of protecting DNA against UV radiation for detecting the results of gel electrophoresis. Patent RU №2465576 19.09.2011.

14. Deryabin D.G., Davydova O.K., Gryazeva I.V., El-Registan G.I. Involvement of alkylhydroxybenzenes in the Escherichia coli response to the lethal effect of UV irradiation // Microbiology.  — 2012.  — Vol. 81.  — №2.  — P. 168-177.

15. Deryabin D., Davydova O., Gryazeva I. Alkylresorcinols protect the DNA from UV-damage in vitro and in vivo models / "Products and Applications of Biopolymers" / Edited by C.J.R. Verbeek  — Croatia: InTech, 2012.  — P.185-200.

16. El-Registan G.I., Mulyukin A.L., Nikolaev Y.A., Stepanenko I.Yu., Kozlova A.N., Martirosova E.I., Shanenko E.F., StrakhovskayM.G., Revina A.A. The role of microbial low-molecular-weight autoregulatory factors (alkylhydroxybenzenes) in resistance of microorganisms to radiation and heat shock // Advances in Space Research.  — 2005.  — Vol. 36 (9).  — P. 1718–1728.

17. Ilinskaia O.N., Kolpakov A.I., Zelenikhin P.V., Kruglova Z.F., Choidash B., Doroshenko E.V., Muliukin A.L., El-Registan G.I. The effect of anabiosis autoinducers on the bacterial genome// Microbiology.  — 2002.  — Vol. 71.  — №2.  — Р. 194–199.

18. Gasiorowski K., Brokos B., Kozubek A.J., Oszmianski J. The antimutagenic activity of two plant-derived compounds. A comparative cytogenic study // Cellular and Molecular Biology Letters.  — 2000.  — №5.  — Р. 171–190.

19. Chhabra R.S., Huff J.E., Haseman J., Hall A., Baskin G., Cowan M. Inhibition of some spontaneous tumors by 4-hexylresorcinol in F344/N rats and B6C3F1 mice // Fundam Appl Toxicol. –1988.  — Vol. 11(4). –P. 685-690.

20. Ross A.B., Redeuil K., Vigo M., Rezzi S., Nagy K. Quantification of alkylresorcinols in human plasma by liquid chromatography/tandem mass spectrometry // Rapid Communications in Mass Spectrometry.  — 2010.  — Vol. 24.  — №5.  — Р. 554–560.

21. Deryabin D.G., Mikhailenko N.A., El-Registan G.I.The effect of alkylhydroxybenzenes on the antigen-binding capacity of antibodies // Microbiology.  — 2009.  — Vol.78.  — №5.  — P. 569-574.

22. Deryabin D.G., Romanenko N.A., Sviridova T.G., El-Registan G.I. Influence alkiloksibenzolov the stability of the functional characteristics of the antibodies in aqueous solutions // Questions of biological, medical and pharmaceutical chemistry.  — 2012.  — №2.  — P. 38-43.

23. Atrooz O.M. Formation of Highly Antioxidative Liposomes from Crude Acetone Extracts of Canna indica, Cucumus melo, and Prunus Armeniaca //Asian Journal of Biochemistry. 2012. — №7(4).  — Р. 218-225.

24. Kozubek A., Gubernator J., Przeworska E., Stasiuk M. Liposomal drug delivery, a novel approach: PLARosomes // Acta biochimica Polonica.  — 2000.  — Vol. 47.  — №3.  — P. 639–649.

25. Gryazeva I.V., Davydova O.K., Deryabin D.G., Sviridova T.G., Sviridov A.P. The predicted and experimentally detectable antioxidant activity alkiloksibenzolov (alkylresorcinols) // Questions of biological, medical and pharmaceutical chemistry.  — 2013.  — №8.  — P. 41-46.

26. Korotkova A.M., Davydova O.K. Effects of synthetic alkylresorcinols on dna topological changes, mediated by reactive oxygen species in vitro system // Vestnik Orenburgskogo Gosudarsvennogo Universiteta.  — 2015. — №6 (181). — P. 157-164.

27. Gryazeva I.V., Davydova O.K., Deryabin D.G. Evaluation of the potential of alkylresorcinols as superoxide anion scavengers and sox-regulon modulators using nitrobluetetrazolium and bioluminescent cell-based assays // Cellular and Molecular Biology Letters.  — 2015.  — Vol. 20. — №1. — Р. 24-37.

28. Davydova O.K., Gavrish I.A.Creation of liposomal structures on the basis of alkylresorcinols and their properties investigation //Vestnik Orenburgskogo Gosudarsvennogo Universiteta.  — 2013.  — №10 (159).  — P. 108-111.

29. DavydovaO.K., GavrishI.A.Evaluation of cytotoxicity derivatives alkiloksibenzolov using cell test systems// Materials of All-Russian symposium with international participation "Current problems of physiology, ecology and biotechnology of microorganisms" [Otsenka stepeni tsitotoksichnosti proizvodnyih alkiloksibenzolov s ispolzovaniem kletochnyih test-sistem // Materialyi Vserossiyskogo simpoziuma s mezhdunarodnyim uchastiem "Sovremennyie problemyi fiziologii, ekologii i biotehnologii mikroorganizmov"]. –М.: MAKS:Press.  — 2014.  — P. 70.

30. Davydova O.K., Nikiyan H.N., Gavrish I.A. Liposomal Transport Systems Based on Alkylresorcinols with Antioxidant Action. XII Inrernational Conference on Nanostructured Materials, Moscow.  — 2014.

31. Davydova O.K., Deryabin D.G., El-Registan G.I. Long-term preservation of DNA in aqueous solutions in the Presence of the chemical analogues of microbial autoregulators // Microbiology.  — 2006. –Vol. 75.  — №5.  — P. 662-669.


About this article

Author: Davydova O.K.

Year: 2015


Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

Crossref
Cyberleninka
Doi
Europeanlibrary
Googleacademy
scienceindex
worldcat
© Электронное периодическое издание: ВЕСТНИК ОГУ on-line (VESTNIK OSU on-line), ISSN on-line 1814-6465
Зарегистрировано в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций
Свидетельство о регистрации СМИ: Эл № ФС77-37678 от 29 сентября 2009 г.
Учредитель: Оренбургский государственный университет (ОГУ)
Главный редактор: С.А. Мирошников
Адрес редакции: 460018, г. Оренбург, проспект Победы, д. 13, к. 2335
Тел./факс: (3532)37-27-78 E-mail: vestnik@mail.osu.ru
1999–2021 © CIT OSU