2015, № 12 (187)

1. Harper S.J., Bates D.O. VEGF-A splicing: the key to anti-angiogenic therapeutics? // Nat. Rev. Cancer. 2008. Vol. 8, № 11. P. 880–887.

2. Ferrara N., Gerber H.-P., LeCouter J. The biology of VEGF and its receptors. // Nat. Med. 2003. Vol. 9, № 6. P. 669–676.

3. Gerhardinger C. et al. Expression of vascular endothelial growth factor in the human retina and in nonproliferative diabetic retinopathy. // Am. J. Pathol. 1998. Vol. 152, № 6. P. 1453–1462.

4. Qiu Y. et al. Overexpression of VEGF165b in podocytes reduces glomerular permeability. // J. Am. Soc. Nephrol. 2010. Vol. 21, № 9. P. 1498–1509.

5. Stalmans I. et al. Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms // J. Clin. Invest. 2002. Vol. 109, № 3. P. 327–336.

6. Stewart M.W. The expanding role of vascular endothelial growth factor inhibitors in ophthalmology // Mayo Clin. Proc. Elsevier Inc., 2012. Vol. 87, № 1. P. 77–88.

7. Carmeliet P., Tessier-Lavigne M. Common mechanisms of nerve and blood vessel wiring. // Nature. 2005. Vol. 436, № 7048. P. 193–200.

8. Pagиs G., Pouyssйgur J. Transcriptional regulation of the Vascular Endothelial Growth Factor gene — A concert of activating factors // Cardiovasc. Res. 2005. Vol. 65, № 3. P. 564–573.

9. Kim I. et al. Constitutive Expression of VEGF, VEGFR-1, and VEGFR-2 in Normal Eyes // Invest Ophthalmol Vis Sci. 1999. Vol. 40. P. 2115–2121.

10. Blaauwgeers H.G. et al. Polarized vascular endothelial growth factor secretion by human retinal pigment epithelium and localization of vascular endothelial growth factor receptors on the inner choriocapillaris. Evidence for a trophic paracrine relation. // Am. J. Pathol. 1999. Vol. 155, № 2. P. 421–428.

11. Saint-Geniez M. et al. Endogenous VEGF is required for visual function: Evidence for a survival role on Muller cells and photoreceptors // PLoS One. 2008. Vol. 3, № 11. P. 1–13.

12. Campochiaro P. a. Ocular neovascularization // Angiogenes. An Integr. Approach From Sci. to Med. 2008. Vol. 91, № 3. P. 517–531.

13. Smith L.E.H. et al. Oxygen-induced retinopathy in the mouse // Investig. Ophthalmol. Vis. Sci. 1994. Vol. 35, № 1. P. 101–111.

14. Aiello L.P. et al. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. // Proc. Natl. Acad. Sci. U. S. A. 1995. Vol. 92, № 23. P. 10457–10461.

15. Alon T. et al. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. // Nat. Med. 1995. Vol. 1, № 10. P. 1024–1028.

16. Pierce E.A. et al. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. // Proc. Natl. Acad. Sci. U. S. A. 1995. Vol. 92, № 3. P. 905–909.

17. Blanco R., Gerhardt H. VEGF and Notch in tip and stalk cell selection // Cold Spring Harb. Perspect. Med. 2013. Vol. 3, № 1. P. 1–19.

18. Tobe T. et al. Evolution of neovascularization in mice with overexpression of vascular endothelial growth factor in photoreceptors // Investig. Ophthalmol. Vis. Sci. 1998. Vol. 39, № 1. P. 180–188.

19. Kwak N. et al. VEGF is major stimulator in model of choroidal neovascularization // Investig. Ophthalmol. Vis. Sci. 2000. Vol. 41, № 10. P. 3158–3164.

20. Lassota N. et al. Natural history of choroidal neovascularization after surgical induction in an animal model // Acta Ophthalmol. 2008. Vol. 86, № 5. P. 495–503.

21. Oshima Y. et al. Increased expression of VEGF in retinal pigmented epithelial cells is not sufficient to cause choroidal neovascularization // J. Cell. Physiol. 2004. Vol. 201, № 3. P. 393–400.

22. Leonard D.S. et al. Clinicopathologic correlation of localized retinal pigment epithelium debridement // Investig. Ophthalmol. Vis. Sci. 1997. Vol. 38, № 6. P. 1094–1109.

23. Sakamoto T. et al. Vessel formation by choroidal endothelial cells in vitro is modulated by retinal pigment epithelial cells // Arch Ophthalmol. 1995. Vol. 113, № 4. P. 512–520.

24. Gogat K. et al. VEGF and KDR gene expression during human embryonic and fetal eye development. // Invest. Ophthalmol. Vis. Sci. 2004. Vol. 45, № 1. P. 7–14.

25. Yi X. et al. Time-course expression of vascular endothelial growth factor as related to the development of the retinochoroidal vasculature in rats. // Exp. Brain Res. 1998. Vol. 118, № 2. P. 155–160.

26. Roberts W.G., Palade G.E. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. // J. Cell Sci. 1995. Vol. 108. P. 2369–2379.

27. Marneros A.G. et al. Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function // Am J Pathol. 2005. Vol. 167, № 5. P. 1451–1459.

28. Provis J.M. et al. Development of the human retinal vasculature: cellular relations and VEGF expression. // Exp. Eye Res. 1997. Vol. 65, № 4. P. 555–568.

29. West H., Richardson W.D., Fruttiger M. Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes. // Development. 2005. Vol. 132, № 8. P. 1855–1862.

30. Schwarz Q. et al. Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve // Genes Dev. 2004. Vol. 18. P. 2822–2834.

31. Mi H., Haeberle H., Barres B. a. Induction of astrocyte differentiation by endothelial cells. // J. Neurosci. 2001. Vol. 21, № 5. P. 1538–1547.

32. Louissaint A. et al. Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain // Neuron. 2002. Vol. 34, № 6. P. 945–960.

33. Bцcker-Meffert S. et al. Erythropoietin and VEGF promote neural outgrowth from retinal explants in postnatal rats // Investig. Ophthalmol. Vis. Sci. 2002. Vol. 43, № 6. P. 2021–2026.

34. Nishijima K. et al. Vascular endothelial growth factor-A is a survival factor for retinal neurons and a critical neuroprotectant during the adaptive response to ischemic injury. // Am. J. Pathol. 2007. Vol. 171, № 1. P. 53–67.

35. Ruiz de Almodovar C. et al. Role and therapeutic potential of VEGF in the nervous system. // Physiol. Rev. 2009. Vol. 89, № 2. P. 607–648.

36. Foxton R.H. et al. VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma // Am. J. Pathol. American Society for Investigative Pathology, 2013. Vol. 182, № 4. P. 1379–1390.

37. Beazley-Long N. et al. VEGF-A165b is an endogenous neuroprotective splice isoform of vascular endothelial growth factor a in vivo and in vitro // Am. J. Pathol. American Society for Investigative Pathology, 2013. Vol. 183, № 3. P. 918–929.

38. Kurihara T. et al. Targeted deletion of Vegfa in adult mice induces vision loss // J. Clin. Invest. 2012. Vol. 122, № 11. P. 4213–4217.

39. Brar V.S. et al. Bevacizumab neutralizes the protective effect of vascular endothelial growth factor on retinal ganglion cells. // Mol. Vis. 2010. Vol. 16, № May. P. 1848–1853.

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