October 2015, № 10 (185)

Fomina M.V., Kirgizova S.B., Aznabaeva L.M., Mikhailova E.A. NEW OPPORTUNITIES DRUGS USED IN TREATMENT OF BACTERIAL INFECTIONS, FOR THE PREVENTION OF BACTERIA CARRIERSanation / preventive measures of carrier state from the body — one of the problems of modern medicine. Search for fundamentally new approaches, which should include an environmentally sound and individualized methods needed to improve the rehabilitation / prevention of bacteria. The possibility of using biologically active substances (endogenous interferon inducers and antibiotics) used in therapy for the prevention of bacterial infections Staphylococcus aureus carriers on the mucosa of the upper respiratory tract was investigated. Anticarnosine sign of staphylococci that in the differential diagnosis of transient resident of bacteria, was the most highly informative and the ability of bacteria to biofilm formation, is caused by infection and long-term persistence of the pathogen in the body used to work as a biological targets. It was found that the most significant reduction in anticarnosine feature of the original value recorded under the influence of substances of synthetic origin. The highest result of inhibiting drugs accounted for interferon inducers of class acridone — Neovir (71.2 ± 10.0 % ↓) and Cicloferon (74.6 ± 7.9% ↓). Chosen concentration and studied the action subinhibitory concentrations of antibiotics ampicillin and ceftriaxone. It was revealed that in subbacteriostatic concentrations, they have the same in direction but at different severity of effect on the ability of bacteria to form a biofilm. Both drugs inhibit the ability of bacteria to form a biofilm, thus more effective was ceftriaxone (67.7 ± 3.5% ↓) compared with ampicillin (55.1 ± 3.9% ↓). The data on the nature of the impact of drugs on the persistent characteristics of staphylococci can be used for the selection of promising new drugs for preventive measures of Staphylococcus aureus bacteria carriers.Key words: bacteria carriage, Staphylococcus aureus, interferon inductors, antibiotics.

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About this article

Authors: Mihaylova E.A., Fomina M.V., Kirgizova S.B., Aznabaeva L.M.

Year: 2015

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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