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2015, № 1 (176)

Mikhailov N.R., Kalinina T.N., Tuchkov D.Y., Losin E.I., Abakumov G.G. TOXOPLASMOSIS OF THE BRAIN OF HIV-INFECTED PATIENTS IN ORENBURGToxoplasmosis of the brain is one of the leading opportunistic infection in patients with HIV infection, it takes third place in the structure of deaths in patients with AIDS. Deaths in toxoplasmosis is a profound immunosuppression due to severe, late diagnosis and treatment. Early detection of cerebral toxoplasmosis in HIV infection is very difficult due to the lack of pathognomonic clinical symptoms, low information content of results of routine laboratory studies. The analysis of the survey results 42 HIV-infected patients with cerebral toxoplasmosis treated in Orenburg regional infectious diseases hospital from 2009 to November 2014. The estimation of the frequency and severity of major clinical symptoms, results of the survey studied by PCR for the presence of toxoplasma DNA in the cerebrospinal fluid, determined by the frequency of detection of immunoglobulin G to Toxoplasma gondii in the blood, their importance for the verification of toxoplasmosis of the brain in patients with HIV infection. The main radiographic manifestations of cerebral toxoplasmosis. It was found that the risk group are HIV-infected patients with CD4 lymphocyte level of less than 100 cells in 1 l of serum. It is shown that in most cases of toxoplasmosis combined with other opportunistic infections, so that all patients have been identified candidiasis of the oral mucosa. A clinical case illustrates typical for toxoplasmosis of the brain in HIV-infected patients with severe immune deficiency. Timely diagnosis, adequate treatment started with the accession of subsequent antiretroviral therapy has a positive effect.Key words: HIV infection, toxoplasmosis of the brain, immune suppression.


1. HIV: clinical features, diagnosis and treatment / V.V. Basil, T.N. Ermak V. Belyaeva et al. — M .: GEOTAR-MED, 2003. — 488 p.

2. Hoffman, K. Treatment of HIV Infection: 2011. / Ed. K. Hoffman, J.K. Rokshtro. — M .: R.Valent, 2012. — 736 p.

3. Belyakov, N.A. Neuroscience and HIV / N.A. Belyakov, T.N. Trofimova, V.V. Rassokhin. — Medical theme archive. — St. Petersburg: Baltic Medical Education Center, — 2013. — 306 p.

4. Proliferations of weakly suppressive regulatory CD4 + T cells is associated with over-active CD4 + T cell responses in HIV-positive patients with mycobacterial immune restoration disease / N. Seddiki, S.C. Sasson, B. Santer et al. // Eur. J. Immunol. — 2009. — Vol.39. — P. 391-403.

5. Pharmacoeconomic analysis of highly active antiretroviral therapy for HIV resistance / N.A. Belyakov, N.V. Sizov, S.E. Toporov and others. // HIV and immunosuppression. — 2010. — V.2. №4. — S. 17.

6. Sergey V. Parasitic diseases of man (protozoonozy and helminth infections): A Guide for Physicians / V.P. Sergei Y. Lobzin, S.S. Kozlov. — SPb .: OOO "Publishing Tome", 2006. — 592 p.

7. Bartlett, J. Clinical aspects of HIV infection. 2009-2010 / J. Bartlett, J. Gallant, P. Farm. — M .: RValent, 2010. — 490 p.

8. Reasons for discontinuation of HAART results of long-term monitoring of patients with HIV / S.I. Dvorak, E.V. Stepanova, N.V. Sizov et al. // HIV and immunosuppression. — 2011 — V.3. — №3. — S.52-57.

9. Onishchenko G.G. HIV — human problem / G.G. Onishchenko // HIV and immunosuppression. — 2009. — Vol.1. №1. — P. 5-9.

10. Belyakov, N.A. Human immunodeficiency virus — Medicine / N.A. Belyakov, A.G. Rakhmanov. — SPb .: The Baltic Medical Education Center, 2010. — 323 p.

11. The use of immunological and molecular — biological methods for the diagnosis of cerebral toxoplasmosis in HIV / E.V. Gubarev, D.B. Goncharov, E.A. Domonova et al. // Medical Parasitology and parasitic diseases. — 2013 №1. — P. 7-12.

12. Cerebral toxoplasmosis in the structure of secondary lesions of the central nervous system in patients with HIV infection in the Russian Federation. Clinical diagnostic features / T.N. Ermak, A.B. Peregudova, V.I. Shakhgildyan et al. // Medical Parasitology and parasitic diseases — 2013.- №1.- C. 4.

13. Stankeeva, O.B. Toxoplasmosis of the brain in HIV — infected patients / O.B. Stankeeva, V.B. Musatov, A.A. Yakovlev // HIV and immunosuppression. — 2013. — Volume 5.- №1. — S. 61.

14. Peregudova, A.B. Toxoplasmosis in HIV-infected patients: clinical features and diagnosis: Abstract of dissertation for the degree of candidate of medical sciences / A.B. Peregudova. — Moscow, 2013. — 23 p.

About this article

Authors: Mihaylova N.R., Kalinina T.N.

Year: 2015

Sergey Aleksandrovich

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