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Fadeeva A.V. COMPARATIVE ANALYSIS OF THE PHOTORECEPTOR LAYER PATIENTS WITH SUBRETINAL NEOVASCULARIZATION FOLLOWING PHOTODYNAMIC THERAPY AND ANTI-VEGF-THERAPYThis article describes the problems in the treatment of subretinal neovascularization. A comparative analysis of the photoreceptor layer thickness in patients with subretinal neovascularization after photodynamic therapy and anti-VEGF-therapy for age-related macular degeneration.Subretinal neovascularization is one of the leading reasons for the decline of central vision in the age group of patients older than 50 years. With the introduction of the treatment of this group of patients photodynamic therapy and anti-VEGF-therapy there was a significant improvement in treatment outcomes.Since November 2002, in the laser department of the Samara Regional Clinical Hospital named after ophthalmic T.I. Eroshevsky performed PDT using the photosensitizer Vizudin (firm Novartis Ophthalmics) and laser photoactivators OPAL (firm Lumenis).). Since 2009, the practice GBUZ SOKOB by T.I. Eroshevsky technique has been introduced anti-VEGF therapy with Lucentis. During this time held in 1536 intravitreal injections of Lucentis (IVVL) in 591 patients with age-related macular degeneration (AMD). This treatment was carried out in the framework of the Programme,developed by the Ministry of Health and Social Development of the Samara region "in order to implement the activities of the priority national project in the field of health care, improve the quality and availability of high-tech medical aid to the population of the Russian Federation." There were analyzed 31 patients with subretinal neovascularization developed against age-related macular degeneration after photodynamic therapy and anti-VEGF-therapy. Of these patients after PDT, 16 (9 patients after PDT, patients after PDT combined with corticosteroids 7), 15 patients after IVVL photoreceptor layer measurement was carried out at a distance of 500 to1000 m from the edge of the subretinal membrane optical coherence tomography RTVue.Key words: vizudin, subretinal neovascularization, photodynamic therapy, anti-VEGF-therapy.
References:
1. Ranibiumab versus verteporfin for neovascular age-related macular degeneration / D.M. Brown [et al.] // N Engl J Med. — 2006. — 355. — P. 1432–1444.
2. Effects of photodynamic therapy using verteporphin on experimental choroidal neovascularization and normal retina and choroids up to 7 weeks after treatment / D. Husain [et al.] // Invest. Ophtalmol. Vis. Sci. — 1999. — Vol. 40. — Р. 2322–2331.
About this article
Author:
Year: 2014
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Editor-in-chief |
Sergey Aleksandrovich
MIROSHNIKOV |
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