|
|
|
Tinkov A.A., Nikonorov A.A. INFLUENCE OF IRON AND COPPER CONSUMPTION ON ADIPOGENESIS AND ATHEROGENESIS INITIATION IN WISTAR RATSThe aim of the current study was investigation of the iron and copper consumption of the adipogenic effect of the high-fat diet and development of atherogenic changes of the lipoprotein profile in Wistar rats. It has been shown that Fe2+ and Cu2+ consumption potentiates the adipogenic effect of the high-fat diet as assessed by absolute and relative adipose tissue content in the rats' organism. It has been estimated that ecologically-relevant doses of iron and copper induce atherogenic changes in the serum lipoprotein spectra in the experimental animals.Key words: iron, copper, high-fat diet, atherogenesis, adipogenesis.
References:
1. Meerson F.Z., Tverdokhlib V.P., Nikonorov A.A., Filippov V.K., Frolov B.A. The role of suppression of cholesterol 7-hydroxylase activity of the liver in the development of atherogenic stress-induced dyslipoproteinemia. Kardiologiia. 1988;28(9):85-87.
2. Baillie-Hamilton PF. Chemical toxins: a hypothesis to explain the global obesity epidemic. J. Altern. Complement. Med. 2002; 8: 185-192
3. Gaenzer H., Marschang P., Sturm W., Neumayr G., Vogel W., Patsch J., Weiss G. Association between increased iron stores and impaired endothelial function in patients with hereditary hemochromatosis. J Am Coll Cardiol. 2002; 40(12):2189-94.
4. Graham R.M., Chua A.C., Carter K.W., Delima R.D., Johnstone D., Herbison C.E., Firth M.J., O'Leary R., Milward E.A., Olynyk J.K., Trinder D. Hepatic iron loading in mice increases cholesterol biosynthesis. Hepatology, 2010; 52(2):462-71.
5. Ohguchi S., Ichimiya H., Yagi A., Hayashi H., Sakamoto N. Copper-induced hypercholesterolemia of golden hamsters: enhanced synthesis of cholesterol in the liver. Gastroenterol Jpn. 1988; 23(6):629-32.
6. Valko M., Morris H., Kronin MTD: Metals, toxicity and oxidative stress. Curr Med Chem. 2005; 12(10):1161-1208
7. Yuan X.M., Li W. The iron hypothesis of atherosclerosis and its clinical impact. Ann Med. 2003; 35(8):578-91.
About this article
Authors: Tinkov A.A., Nikonorov A.A.
Year: 2013
|
|
Editor-in-chief |
Sergey Aleksandrovich MIROSHNIKOV |
|
|