2013, № 10 (159)

Sizova Е.А., Polyakova V.S. ASSESSMENT OF THE INTENSITY OF REACTION PERLS IN THE TARGET ORGAN IN RATS WHEN ADMINISTERED IRON NANOPARTICLESThe results of studies of the effect of iron nanoparticles on the intensity of display quality response to iron in the spleen and liver in the intramuscular route of administration of the body. The intensity of the reaction in the organs is dose-dependent. In the liver, marked individual hepatocytes and Kupffer cells giving a positive reaction and activation work. In the spleen, only at a dose of 6 mg/kg macrophages give a positive reaction, while increasing the dose to 14 mg/kg reduced the number of cells having positive Perls, indicating deployment kompensatono-adaptation reactions aimed at preventing the organ hemosiderosis.Key words: nanoparticles of iron, liver, spleen, Perls reaction

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About this article

Authors: Sizova E.A., Polyakova V.S.

Year: 2013

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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