Notova S.V., Slobodskov A.A., Bokov D.A., Sizova E.A.
SRC GENE EXPRESSION IN CHANGING PLACENTAL TISSUESAFTER EXPOSURE TO COPPER NANOPARTICLES ^{[№ 12 ' 2016]}
The SRC gene is a protooncogene with vague regulatory functions. Protein products of its expression are tyrosinkinases that modulate membrane receptors to cytokines involved in cell proliferation and differentiation. Placental insufficiency and placental immaturity are characterized by complicated pathogenesis, so morphogenetic and regulatory aspects of their development are not clearly defined. In addition, inevitable usage of nanostructured substances for the purpose of medical diagnosis and treatment is presently evident. There were shown toxigenic features of nanoparticles for placental tissues leading to intolerable decline in surface area of the chorion and fetal-placental metabolic rate. The aim of the research is to establish connections between c-src gene expression and structural processes of chorial remodeling after damage. The study shows the main mechanisms of placental adaptation after exposure to copper nanoparticles (dose 1.0 mg/kg) administered to pregnant Wistar rats throughout the gestation period. The first mechanism consists in the increase in the proportion of intermediate villi and their processes, the second one is the increase in volume of syncytial knots. As a result, new formation of structures is observed, including terminal villi. The src gene expression was detected in epithelial cells of syncytial knots, as well as on separate epithelial sites of intermediate and terminal villi (induced epithelium). SRC gene is also actively expressed in fibroblasts of fetal stroma. Decidua and peripheral portion of trophoblast in spongy zone do not contain signs of SRC gene activity. Thus, there was established that SRC gene plays a regulatory role increasing processes of chorionic villi growth in placenta after exposure to copper nanoparticles and consequent damage.

Miroshnikov S.V., Notova S.V., Kiyaeva E.V., Alidzhanova I.E., Slobodskov A.A.
FEATURES OF HAIR AND VARIOUS THYROID STRUCTURES ELEMENT COMPOSITION IN ENDEMIC IODINE DEFICIENCY REGION ^{[№ 10 ' 2013]}
The results of the study of the element composition of the hair and the various structures of the thyroid gland of women living in the Orenburg region are presented. It is established that in the pathogenesis of proliferation of thyroid cells leading to the formation of nodular thyroid pathology not only iodine is important. Cd, Sn, Ni, Zn and Cu participate in the disruption of expression of autocrine growth factors in the thyroid gland.