Musina L.A., Nuraeva A.B.
BURN WOUND HEALING WHEN USING ALLOGENIC BIOMATERIALS (EXPERIMENTAL STUDY) ^{[№ 12 ' 2015]}
Prevention of eyelid cicatricial deformity secondary to trauma or burn is the unmet need in ophthalmosurgery. In order to understand the mechanisms of tissue regeneration after eyelid surgical repair using allogenic biomaterials it is interesting to compare burn wound healing process without treatment, using conventional medications (Actovegin) and with the use of allogenic biomaterials in experiment. In the experiment was conducted on 84 white Wistar male-rats. Heat injury was modeled. In control group without treatment the healing process was accompanied by prolonged eschar presence, late epithelisation and slowdown of newly formed connective tissue maturation due to marked inflammation process. Reparation was incomplete and accompanied by coarse scarring. In the second control group treated with Actovegin the epithelisation was faster, nevertheless slowdown of reparation process in dermal layer was noticed. Inflammatory processes prevailed over reparative ones, granulation tissue stayed immature for a long time and eventually underwent scarring. In treatment group where animals underwent subcutaneous injection of disperse biomaterials (made from derma and tendon) rapid proliferation of epithelium was noted as long as necrotic mass demarcation and fast eschar desquamation. As granulation tissue matured it formed proper connective tissue plate of skin. It was found that the use of allogenic biomaterials in skin burns accelerated epithelisation and leaded to complete defect closure. Biomaterials inhibit coarse scarring during healing process.

Nuraeva A.B.
SURGICAL REPAIR OF EYELID CICATRICAL ENTROPION AND TRICHIASIS ^{[№ 12 ' 2015]}
In this study the results of surgical treatment of eyelid cicatrical entropion and trichiasis with Alloplant biomaterial for eyelid plasty as an adjuct to autological transplantation of labial mucous membrane. Cicatricial entropion could be secondary to chemical burn or trauma, as long as chronical allergic or infectious process in conjunctiva, Stivens-Johnes disease, Layell syndrome and Sjogren's syndrome. Scarring process starting from conjunctiva involves tarsus and changes eyelid position into entropion. This is usually accompanied by trichiasis which promotes chronical inflammation of conjunctiva and may lead to secondary keratitis, corneal ulcer and corneal opacification. Patients usually experience discomfort from eyeball rubbing by eyelashes, excessive tearing and photophobia due to corneal syndrome. 32 patients with cicatricial entropion of upper eyelid and 29 patients with cicatricial entropion of lower eyelid were followed up in reconstructive and plastic surgery department of our clinic. Eyelid deformities were caused by burn, trauma, Layell syndrome and Stivens-Johnes disease. All patients underwent eyelid entropion surgical repair using know-how surgical technique with the use of Alloplant biomaterial for eyelid plasty and autological labial mucous membrane. During follow up of three years complete entropion and trichiasis repair was observed in all patients. All patients experienced symptoms improvement marked as relief in corneal irritation symptoms, excessive tearing and photophobia disappearance. Special regenerative properties of Alloplant for eyelid plasty provided good transplant survival. Newly formed adequate eyelid frame with anatomically correct position of eyelashes prevented from entropion and trichiasis recurrence.

Muldashev E.R., Nigmatullin R.T., Nuraeva A.B., Shcherbakov D.A., Yanborisov T.M., Gizatullina E.R.
THE PROSPECTS OF R4 CONCEPT IMPLEMENTATION IN THE CRANIOFACIAL SURGERY ^{[№ 12 ' 2012]}
There are analyzed the possibilities of the basic points of "P4 Medicine" doctrine implementation in reconstructive surgery of skeleton and soft skeleton face in the article. There are considered the opportunities of personification and predictive of the treatment, relapse prevention and patient responsibility as an example of regenerative surgery of Alloplant technology. It is shown that transplantation methods of therapy in the craniofacial surgery are perfectly fit to the basic principles of medicine P4 and can be considered as its integral part. Transplantology can effectively use the achievements of systemic and evolutionary biology, genomics, information and nanotechnology in the format of the new paradigm of clinical medicine.

Shcherbakov D.A., Nuraeva A.B., Musina L.M.
INFERIOR ORBIT WALL RECOVERY USING CHONDRAL ALLOGRAFTS ^{[№ 12 ' 2012]}
We have proved experimentally what the feasibility of chondral allografts for reimbursement of various defects of the inferior orbit wall. In the clinical part of the study we have developed indications for plate chondral allograft for fractures of the inferior orbital wall type blow-out with prolapse of orbital contents into the maxillary sinus and the combination of connective biomaterials to reconstruct small defects of the inferior orbital wall.

Galimova V.U., Kamilov F.Kh., Gazdalieva L.M., Nuraeva A.B.
INFLUENCE OF SURGERY TREATMENT OF POSTTRAUMATIC EYE PREATROPHY ON THE LEVEL OF NITRIC OXIDE IN BLOOD PLASMA AND LACRIMAL LIQUID ^{[№ 12 ' 2007]}

Muldashev E.R., Galimova V.U., Nuraeva A.B.
INDEXES OF LEVEL OF FINAL STABLE METABOLITES OF NITRIC OXIDE OF PATIENTS WITH BULLOUS CARETOPATHY ^{[№ 12 ' 2007]}

Gazdalieva L.M., Nuraeva A.B., Kamilov F.Kh., Galimova V.U.
LEVEL OF FINAL STABLE METABOLITES OF GOLD OXIDE OF PATIENTS WITH BULLOUS KERATOPATHY ^{[№ 13 ' 2004]}

Muldashev E.R., Galimova V.U., Nuraeva A.B.
RESULTS OF SURGICAL TREATMENT OF ENDOTHELIALIS AND EPITHELIAL DYSTROPHY OF CORNEA ^{[№ 13 ' 2004]}

Salikhov A.Yu., Muldasheva I.E., Salikhov E.A., Nuraeva A.B.
ALLOPLASTY IN OPHTHALMO-ONCOLOGY IS NEW STAGE OF PATIENTS QUALITY LIFE IMPROVMENT ^{[№ 13 ' 2004]}