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Orenburg State University january 20, 2022 RU/EN
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Korotkov A.M., Lebedev S.V., Rusakov E.A.
DNA-DAMAGING EFFECTS OF NANOPARTICLES NI AND NIO FOR EXAMPLE A PLANT SPECIES TRITICUM VULGARE [№ 10 ' 2015]
The effects of spherical nanoparticles of nickel Ni˚ diameter of 70±0,3nm and nickel oxide NiO diameter of 94±0,3nm in three dilutions— 0.025, 0.05 and 0.1M at the root of the 4-day seedlings of Triticum vulgare. After 48hour incubation with nanoparticles plants recorded dose dependent increase in DNA fragmentation. Electrophoretic separation of DNA showed the change in mobility from the perspective of reducing the amount of content the least migratory agarose gel closest to the start of the fragments formI (1000bp), constituting the largest amount in the control samples, and the transition of the bulk of the DNA fragments from -flowing nucleotides (formII— less than 1000bp). Thus, under the influence of NPs Ni and NiO in concentrations 0.025–0.1M there was an increase of less than 1000bp fragment (formII) to 53–59% and 55–59,8% with simultaneous reduction of formI at 16,6–20,9% and 15,6–22%, respectively, compared to the control. The calculated results for the coefficient electrophoretogram of DNA damage in the case of 0.025, 0.05 and 0.1M nickel nanoparticles was 1.052±0.009, 1.126±0.043 and 1.2±0.03, and nickel oxide nanoparticles— 0.982±0.02, 1.053±0.013 and 1.192±0.21 (against the background of the control 0.398±0.05), respectively. Linear DNA profile electrophoregrams testified that nanoparticles at low concentrations (0.025 and 0.05M) cause system degradation to discrete DNA fragments from the nucleotide-flowing transition from the bulk of the DNA in the region of less than 1000bp and the concentration is 0.1M appearance of apoptotic "steps" represented by a group of split peaks located descending area, in which a multiple number of DNA 180bp.

Korotkova A.M., Davydova O.K.
EFFECTS OF SYNTHETIC ALKYLRESORCINOLS ON DNA TOPOLOGICAL CHANGES, MEDIATED BY REACTIVE OXYGEN SPECIES IN VITRO SYSTEM [№ 6 ' 2015]
The problem of live systems protection against an oxidizing stress by means of various low-molecular organic compounds capable to neutralize reactive oxygen species attracts the growing interest in search, study and prospects of practical use of both naturaland synthetic antioxidants. Alkylresorcinols known by the function of adaptogens at plants and microorganisms can be also included to their number. In turn, a well-documented effect of alkylresorcinols concerning biopolymers and cells is change of their functional activity and resistance to extreme influences. Because the genetic structure is a one of the most vulnerable targets of various destructive factors, including oxidizing stressinductors, the aim of the work is experimental justification of a role of synthetic alkylresorcinols differing in chemical structure in protection of DNA against reactive oxygen species. The effects of destruction of topologically various molecules of pUC19 plasmid DNA associated with formation of single-stranded breaks and which are expressed in change of a ratio of the supercoiled and nicked molecules under the influence of reactive oxygen species are estimated by agarose gel electrophoresis. The system of photochemical induction of superoxide anion by a spontaneous reoxidation of photoreduced flavin with the subsequent formation of multiple active forms of oxygen is used as a model of an oxidizing stress. The significant prevention of DNA deep degradation in the presence of alkylresorcinols, directly dependent both from length of their alkyl and from the used concentration as compared with the oxidized tests is shown. On the basis of data of infrared spectroscopy the question of possible transformations of alkylresorcinols protecting of DNAconformation in the conditions of an oxidizing stress is discussed. The experimental studies of protector effects ofalkylresorcinol from reactive oxygen species concerning to DNA molecules are forming a basis for pharmaceutical preparations development.

Korotkova M.V., Dokukina S.M., Kalinycheva N.L., Nikitina S.O.
OPTIMIZATION OF FINANCING HIGHER EDUCATION: MODERN RUSSIAN AND GLOBAL TRENDS [№ 4 ' 2015]
The article considers the issues related to financing education sector, funding of higher education, particular budget financing, financing pedagogical universities, the need to improve efficiency in funds usage in the higher education system, optimizing the cost of financing formation, mergers and acquisitions in the higher education system, synergies from the merger of universities.the main directions of minimizing the cost of funding for education, mergers and acquisitions, the mechanism of public-private partnership. The contradictory nature of market relations in the education sphere, the educational infrastructure of the market, increasing competition, providing quality educational services, duplication of specialties (training areas) provides by classic, technical, industrial and pedagogical universities. Integration processes occur in developing interactions between its elements for the growth of holistic properties of systems are not new in the industry, agriculture and other industries in the field of malware is a new stage in the development of education, not only in Russia but also abroad. It is known that by combining interests in horizontal or vertically integrated combination provides a synergistic effect: the creation of a unified scientific-research base, accelerating the development of innovative universities, savings on transaction costs, efficient use of material and technical base, entering the ranking of top 200 world universities , effective use of budget resources and the possibility of raising funds for investment purposes. Federal policies and the script higher vocational education (HVE) financing higher education "based on demand" model, which has a number of competitive advantages that can not be the basis of social development. Russia's lack of mechanisms to facilitate the implementation of areas: the effective implementation of the advantages of this scenario: in particular, the mobility of students and the magistral staff (MS), loans, and the difference between the public and private sector of education. Adequate and operational mechanisms of evaluation and accreditation are important, including independent monitoring and IT-technology.

Korotkova M.V.
INVESTMENT RESOURCES AS ECONOMIC CATEGORY AND MANAGEMENT OBJECT OF INDUSTRIAL ORGANIZATIONS [№ 8 ' 2014]
The article discusses various approaches to the definition of investment resources from the standpoint of increasing the application possibilities for the real sector of economy development and product competitiveness.

Timofeeva D.V., Zinyukhina A.G., Popov V.P., Korotkov V.G., Antimonov S.V.
OPTIMIZATION OF THE CHANGES OF THE AGGREGATIVE STATE OF MATERIALS IN THE EXTRUSION PROCESS [№ 3 ' 2013]
On the basis of the pilot research is proposed to develop Saving Technologies extruded products including adhesive-cohesive interactions permits substantive reduce energy and resource consumption in the production process. This paper investigated the effect of extrusion process various kinds of agricultural raw materials to changes in the physical-chemical, structural, and mechanical properties of the materials being processed.

Korotkov V.G., Popov V.P., Vasilevskaya S.P.
APPLICATION OF THE VECTOR OPTIMIZATION FOR SYNTHESIS AN EXTRUTION TECHNOLOGY OF THE BIOTECHNOLOGY FACILITIES [№ 10 ' 2012]
Multi-criteria methods (vector) optimization of the problem of the optimization of biotechnological process based on the processing of the semi products of plant raw material.

Korotkova M.V.
OPTIMIZATION OF BILL PAYABLE MANAGEMENT IN INDUSTRIAL ENTERPRISES [№ 5 ' 2009]
This article is devoted to the analysis of bill payable management in industrial enterprise. The author analyzes following questions: influence of turnover rate on obligations of the enterprise. The author suggests general variants of optimization of bill payable and trends promoting effective management of bill payable in industrial enterprises.

Kirilenko S.G., Korotkova V.G.
SCIENTIFIC – TECHNOLOGICAL ASPECTS OF FAT-AND OIL INDUSTRY DEVELOPMENT OF THE REGION [№ 9 ' 2005]
Open Society "Orenburg EZ" – the partner of Open Society "NZH" – represents fat-and-oil industry of the food-processing industry of Russia in the Orenburg region. Processing of natural vegetative raw material, release of a wide spectrum of the high-quality production, conducting positions in the market, introduction of scientific and technical actions – these are the priority aspects of development of fat-and-oil sectors of region` economy.

Korotkov V.G., Ganin E.V., Antimonov S.V., Solovyh S.U.
MODELING OF THE PROCESS OF MIXTURE WITH SIMULTANEOUS BREAKAGE OF THE FEED MIXTURES. [№ 5 ' 2004]
Modern conditions of preparing of feed in small and middle farms, tendencies of machine development for recycling of grain - products are viewed in the article, kinetics of the process of mixturing by attendant breakage of grain components and power, expended on this process on the basis of halfemperic model of movement of sphere in mixer of chemical production is described.

Korotkov M., Yamolov Iu
RUN INFLUENCE ASSESSMENT ON ECOLOGICAL SAFETY OF THE AUTOMOBILE VAZ 21102 [№ 1 ' 2003]
In connection with different procedures of engines ecological parameters definition (sanitary - hygienic and technical), the synonymous interrelation between them did not exist. The article deals with ecological safety level change of the automobile VAZ 21102 using the method of vehicles ecological safety and technical perfection level integrated assessment, suggested earlier.


[№ 5 ' 2002]

Bondarenko E.V., Korotkov M.V.
CRITERION CHARACTERISTIC OF ECOLOGICAL SAFETY AND TECHNICAL PERFECTION OF MOTOR TRANSPORT FACILITIES [№ 3 ' 2002]
Different methods of determination of internal-combustion engine ecological indices (sanitary-hygienic and technical) were available, but there was no single relation between them. The authors suggest their method of integral estimation.

Korotkov V. G., Polischuk V. Y., Solovyh S. Y.
KINEMATICS OF SPLITING OPERATION IN GRINDER WORKSPACE. [№ 4 ' 2001]
This work is supposed to describe velocity distribution in a flow. It is discovered in grinder workspace on a base of semiempirical model of medium movement in chemical production mixeres.

V.G. Korotkov, T.M. Zubkova, D.A. Musienko
MIXING THE MATERIALS IN A CYLINDRICAL CANAL [№ 1 ' 2001]
The parameter of a clisplacementTs defect may ke used for a definition of the quality of a mixed product in the canal. The cylindrical canals of spinnerets have become of a great importance, that is why the dependence nas given in the article for a definition of the displacementTs defect in the canal of the cylindrical spinneret. The diagrammes of the changing in the displacementTs defect are given on a radius of the spinnerets canals with different lengthes.

V.G.Korotkov, T.M.Zubkova, D.A.Musiyenko
THE MIXING EXTRUDED PRODUCT IN THE SCREW CHANNEL AND IT'S ESTIMATE. [№ 3 ' 2000]
It's possible to estimate the quality of screw channel mixing by means of shift deformation. To determine the shift deformation in screw channel the dependence in the article is obtained. The dependence can be used to make up the mathematical model of plant materials extrusion for the determination of the effect parameter, which is characterized by the quality of mixing pressed mechanism


Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

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