Klimova T.A., Barysheva E.S., Morozova N.V., Korobova I.V.
APPLICATION OF PROBIOTIC PREPARATIONS BASED ON BACILLUS OF THE GENUS BACILLUS IN THE IRON AND ZINC SYSTEM OF DELIVERY IN THE ORGANISM OF LABORATORY ANIMALS ^{[№ 9 ' 2017]}
Studies in the field of iron and zinc deficiency are caused by the high prevalence of iron deficiency and deficient zinc states according to official statistics of the Ministry of Health of the Russian Federation. It is known that metals in comparison with other elements have the ability to bioaccumulate. Microorganisms are able to extract and concentrate metals, in particular, this ability is possessed by microorganisms that are part of probiotic preparations based on bacteria of the genus Bacillus.
The results of the study of the possibility of delivering iron and zinc to the organism of laboratory animals using probiotic preparations based on bacteria of the genus Bacillus are presented. The probiotic strains were the living and inactivated bacteria of the genus Bacillus: B. subtilis 534, B. cereus 5832, B. licheniformis 7038 and B. subtilis 7048. The data obtained indicate that in the iron delivery system, the most effective probiotic strains studied are inactivated with B. licheniformis 7038 and B. subtilis 7048 (increase in iron in the skin of laboratory animals by 31.7 %, in bone tissue — 80.8 %, in muscle tissue — 75.9 %). In the zinc delivery system, the B. subtilis strain 534 proved to be the most effective, while the zinc content in the skin of laboratory animals increased by 60 %, in bone tissue by 78.5 %, and in muscle tissue by 43.6 %.
In the iron delivery system, the most effective of the drugs being tested is “Vetom-2”, and the least “Sporobacterin”. In the zinc delivery system, the most effective is “Sporobacterin”, and the least effective is “Bactisubtil”.