Vestnik On-line
Orenburg State University november 23, 2024   RU/EN
Headings of Vestnik
Pedagogics
Psychology
Other

Search
Vak
Антиплагиат
Orcid
Viniti
ЭБС Лань
Rsl
Лицензия Creative Commons

March 2015, № 3 (178)



Karmanova D.C., Chesnokova L.A., Krasikov S.I. THE IMPACT OF NON-TOXIC DOSES OF THE HERBICIDE 2,4-DA ON THE DYNAMICS OF BODY WEIGHT OF ANIMALS IN THE EXPERIMENTThe article is devoted to assessing the possible role of the herbicide 2,4-DA (2,4-dichlorophenoxy acid dimethylammonium salt) in the development of overweight in long-term intake of low doses of the substance in the organism of laboratory animals with drinking water. This herbicide is of particular interest, since on the one hand it is widely used in agriculture and its inherent unique combination of such qualities as chemical stability and high lipophilicity contribute to its accumulation in the objects of wildlife and the delay in the body. The results of these studies showed that the uptake of the herbicide 2,4-DA led to a more rapid increase in body weight than the control animals. At the same time, in the experimental group rats showed greater accumulation of adipose tissue, as measured by the criterion weight indicate epididymal fat. Overall, the results showed that the intake of pesticide in doses that are an order of magnitude below the maximum allowable, indicate that when assessing the effects of pollutants of anthropogenic origin, should be paid not only on the ecological validity of these pollutants, but also on the fact of their presence, even at doses that do not have toxic effects.Key words: herbicide, 2,4- dichlorophenoxyacetic acid dimethylammonium salt, obesity

Download
References:

1. Kamilov F. H. Pathochemistry of toxic effects of chlororganic and aromatic compounds / F. H. Kamilov // Medical journal of Bashkortostan. — 2007. — Vol. 2, No. 6. p. 76-80.

2. Shakirova G. R. Morphofunctional status of the thyroid gland under the influence of the herbicide 2,4 and subsequent correction tocopherol and mielopid / G. R. Shakirov, A. B. Imashev, N. And. Mutazilah // Successes of modern science. — 2006. — No. 3. — p.87.

3. Baillie-Hamilton, P. F. Chemical toxins: a hypothesis to explain the global

obesity epidemic / P. F. Baillie-Hamilton // J. Altern. Complement. Med. — 2002. — Vol. 8(2). — p. 185-92.

4. B. Bukowska. Toxicity of 2,4-Dichlorophenoxyacetic Acid — Molecular Mechanisms. Polish J. of Environ. Stud. Vol. 15, No. 3 (2006), 365-374. 5.

5. Bornfeldt, K. E. Insulin resistance, hyperglycemia, and atherosclerosis / K. E. Bornfeldt, I. Tabas // Cell Metab. — 2011. — Vol. 14(5). — p. 575-85.

6. Duk-Hee Lee, Michael W.Steffes, Andreas Sjodin, Richard S.Jones, et al. (2011). Low Dose Organochlorine Pesticides and Polychlorinated Biphenyls Predict Obesity, Dyslipidemia, and Insulin Resistance among People Free of Diabetes.PLoS ONE.-2011.-6(1). p.1-9.

7. Garabrant D. Reviewof 2,4- Dichlorfenoxyacetic Acid (2,4 — D). Epidemiology // Critical Rewiews in Toxicology. 2002. — 32(4). p.233-257.

8. Joosten, HF, Van Der Kroon, PH. Enlargement of epididymal adipocytes in relation to hyperinsulinemia in obese hyperglycemic mice (ob/ob). Metabolism 1974. 23:59-66.

9. Kopelman, P. G. Obesity as a medical problem / P. G. Kopelman // Nature. –2000. — Vol. 404. — p. 635-43.

10. Pijl, H. Obesity: evolution of a symptom of affluence / H. Pijl // Neth. J. Med. — 2011. — Vol. 69(4). — p. 159-66.

11. Prentice, A. M. The emerging epidemic of obesity in developing countries / A. M.Prentice // Int. J. Epidemiol. — 2006. — Vol. 35(1). — p. 93-9.

12. Roden, M. Mechanism of free fatty acid-induced insulin resistance in humans / M. Roden, T. B. Price, G. Perseghin, K. F. Petersen, D. L. Rothman, G. W. Cline, G. I. Shulman // J. Clin. Invest. — 1996. — Vol. 97(12). — p. 2859-65.

13. Thayer K.A., Heindel J.J., Bucher J.R., Gallo M.A. Role of environmental chemicals in diabetes and obesity: a national toxicology program workshop review // Environ Health Perspect 2012; 120:779–789.

14. WHO, 2,4-Dichlorophenoxyacetic Acid (2,4-D), Guidelines for Drinking-Water Quality, second ed., Geneva, 1998.

15. Woods, S. C. Central control of body weight and appetite / S. C. Woods, D. A. D''Alessio // J. Clin. Endocrinol. Metab. — 2008. — Vol. 93(11 Suppl 1). — p. 37-50.


About this article

Author: Krasikov S.I.

Year: 2015


Editor-in-chief
Sergey Aleksandrovich
MIROSHNIKOV

Crossref
Cyberleninka
Doi
Europeanlibrary
Googleacademy
scienceindex
worldcat
© Электронное периодическое издание: ВЕСТНИК ОГУ on-line (VESTNIK OSU on-line), ISSN on-line 1814-6465
Зарегистрировано в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций
Свидетельство о регистрации СМИ: Эл № ФС77-37678 от 29 сентября 2009 г.
Учредитель: Оренбургский государственный университет (ОГУ)
Главный редактор: С.А. Мирошников
Адрес редакции: 460018, г. Оренбург, проспект Победы, д. 13, к. 2335
Тел./факс: (3532)37-27-78 E-mail: vestnik@mail.osu.ru
1999–2024 © CIT OSU