2013, № 4 (153)

Tiganov A.S., Akopyan V.S., Gavrilova S.I., Semenova N.S., Fedorova Ya.B., Gurova Ye.V., Filonenko I.V. THINNING OF RETINAL GANGLION CELLS LAYER IN PATIENTS WITH ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT: THE DIAGNOSTIC VALUE OF SPECTRAL OPTICAL COHERENCE TOMOGRAPHYThis study included 10 patients (20 eyes) with Alzheimer's disease, 10 patients with mild cognitive impairment and 10 age– and sex-matched healthy controls that had no history of dementia. All the subjects underwent psychiatric examination and complete ophthalmological examination, comprising optical coherence tomography. There was a significant decrease in the macular ganglion cell complex (GCC) thickness in patients with Alzheimer"s disease compared to the control group. Weak positive correlation of GCC thickness and psychiatric state was observed.Key words: ganglion cell complex, retinal nerve fiber layer, mild cognitive impairment, Alzheimer's disease, optical coherence tomography.

Download

References:

1. Sperling R.A., Aisen P., et al. Towards defining the preclinical stage of Alzheimer's disease: recommendations from the National Institute on Aging and the Alzheimer's Association workgroup // Alzheimers Dement. — 2011. — Vol. 7. — P. 160-167.

2. Gavrilova S.I., Fedorova Ya.B., Roshchina I.F., Korovaytseva G.I. Prediction of mild cognitive impairment syndrome according to the data of two-year clinical follow-up // Journal of Neurology and Psychiatry. — 2007. — Т. 1. — P. 56-63.

3. Blanks J.C., Torigoe Y., et al. Retinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal/parafoveal retina // Neurobiol Aging. — 1996. — Vol. 17, №3. — P. 377-384.

4. Koronyo-Hamaoui M., Koronyo Y., et al. Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model // Neuroimage. — 2011. — Vol. 54, №1. — P. 204–217.

5. Folstein, M. F., Folstein, S. E, et al. Mini-Mental State. A practical method for grading the cognitive state of patients for the clinician // Journal of Psychiatric Research. — 1975. — Vol. 2. — P. 189–198.

6. Petersen R.C. Mild cognitive impairment as a useful clinical concept // Geriatric Times. — 2004. — Vol. 5 — P. 1-5.

7. Morris J.C. The clinical dementia rating (CDR). Current version and scoring rules // Neurology. — 1993. — Vol.43. — P. 2412-2414.

8. Reisberg B., Ferris S.H., et al. The global deterioration scale (GDS). An instrument for the assessment of primary degenerative dementia // Am J. Psychiatry. — 1982. — Vol. 139. — P. 1136-1139.

9. Hachinski V.C., Lassen N.A., et al. Multi-infarct dementia: a cause of mental deterioration in the elderly // Lancet. — 1974. — Vol. 2. — Р. 207–210.

10. Yesavage J.A. Geriatric Depression Scale // Psychopharmacol Bull. — 1988. — Vol. 24, №4. — P. 709-711.

11. McKhann G., Drachman D., Folstein M., et al. Clinical diagnosis of Alzheimer"s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer"s disease // Neurology. — 1984. — Vol. 146. — P.939-944.

12. Mirra S.S., Hart M.N., Terry R.D. Making the diagnosis of Alzheimer's disease: a primer for practicing pathologists // Arch. Pathol. Lab. Med. — 1993. — Vol. 117. — P. 132-144.

13. Kesler A., Vakhapova V., et al. Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease // Clinical Neurology and Neurosurgery. — 2011. — Vol. 113. — P. 523– 526.

14. Paquet C., Boissonnot M., et al. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease // Neuroscience Letters. — 2007. — Vol. 420. — P. 97–99.

15. Kirbas S., Turkyilmaz K., Anlar O., Tufekci A., Durmus M. Retinal Nerve Fiber Layer Thickness in Patients With Alzheimer Disease // Journal of Neuro-Ophthalmology. — 2013. — Vol. 33, №1. — P. 58-61.

16. Tsolaki F, Gogaki E, et al. Alzheimer's disease and primary open-angle glaucoma: is there a connection? // Clin Ophthalmol. — 2011. — Vol. 5. — P. 887-890.

17. Iseri P.K., Altinas O., et al. Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease // Journal of Neuro-Ophthalmology. — 2006. — Vol. 26, №1. — P. 18–24.

About this article

Authors: Gurova E.V., Tiganov A.S., Akopyan V.S., Gavrilova S.I., Semenova N.S., Fedorova Ya.B., Filonenko I.V.

Year: 2013

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

© Электронное периодическое издание: ВЕСТНИК ОГУ on-line (VESTNIK OSU on-line), ISSN on-line 1814-6465
Зарегистрировано в Федеральной службе по надзору в сфере связи, информационных технологий и массовых коммуникаций
Свидетельство о регистрации СМИ: Эл № ФС77-37678 от 29 сентября 2009 г.
Учредитель: Оренбургский государственный университет (ОГУ)
Главный редактор: С.А. Мирошников
Адрес редакции: 460018, г. Оренбург, проспект Победы, д. 13, к. 2335
Тел./факс: (3532)37-27-78 E-mail: vestnik@mail.osu.ru