2013, № 4 (153)

Solodkova E.G., Boriskina L.N. CORNEAL COLLAGEN CROSSLINKING SAFETY EVALUATION IN TREATMENT OF PROGRESSIVE KERATOCONUS BASING ON REMOTE POSTOPERATIVE RESULTSSafety and efficiency of two corneal collagen crosslinking (CXL) techniques was brought to comparative analysis. CXL was performed in 25 patients with progressive keratoconus: 9 patients (9 eyes) underwent a conventional CXL; 16 patients (16 eyes) had a modified CXL which novelty consisted of a depth-metered deepithelialization performed by excimer laser with on-line pachymetry Schwind Amaris (Germany). UV-A exposure was made by means of "UV-X" device (version 1000) (IROC Inc., Switzerland). All patients were prescribed to wear silicon-hydrogel soft contact lenses until a complete epithelial recovery. Improvement of NCVA, BCVA, topographic parameters, pachymetric values along with integrity of endothelial cell density was registered in all the cases which allows concluding that both CXL methods are safe and have a similar clinical efficiency. Key words: corneal collagen crosslinking, keratoconus.

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References:

1. Solodkova H.G., Remesnikov I.A. Analysis of remote corneal collagen CLX results in treatment of progressive keratoconus // "Practical medicine". — 2012. — Volume 1. — P. 118-120.

2. Feinbaum K. Present-day view at aetiopathogenesis and treatment of keratoconus // Ophthalmosurgery. — 2011. — №3. — P. 80-83.

3. Bahar I., Kaiserman I., Srinivasan S., et al. Comparison of three different techniques of corneal transplantation for keratoconus // Int. Ophthalmol.– 2008.– V. 28. — P.141-146.

4. Colin J., Cochner B., Savary G. et al. Correcting keratoconus with intracorneal rings // J. Cataract. Refract. Surg. — 2000. — V. 26. — P.1117-1122.

5. Ferrara de A., Cunha P. Tecnica cirurgica para correcao de myopia. Аnel corneano intra-estromal // Rev. Bras. Oftalmol. — 1995. — V. 54. — P.577-588.

6. Mazzotta C., Balestrazzi A., Biaocchi S. et al. Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in keratokonus: in vivo confocal microscopic evaluation // Clin. Experiment Ophthalmol. — 2007.-V. 35. — P.580-582.

7. Price F.W., Price M.O., Adult keratoplasty: has the prognosis improved in the last 25 years? // Int. Ophthalmol. — 2008. — V. 28. — P.141-146.

8. Raiskup F., Hoyer A., Spoerl E. Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratokonus // J. Refract. Surg. — 2009. — V.25. — P.824-828.

9. Roe R.H., Lass J.H., Brown G.C., Brown M.M. The value-based medicine comparative effectiveness and cost– effectiveness of penetrating keratoplasty for keratoconus // Cornea. — 2008. — V. 27. — P.1001-1007.

10. Spoerl E., Schreiber J., Hellmund K., Seiler T., Knuschke P. Crosslinking Effects in the cornea of Rabbits // Ophthalmol. — 2000. — V. 97. — P.203-206.

11. Spoerl E., Wollensak G., Seiler T. Inceased Resistance of Crosslinkinked Cornea against Enzymatic Digestion // Current Eye Research. — 2004. — V. 29. — P.35-40.

12. Spoerl E., Wollensak G., Dittert D., Seiler T. Thermomechanical Behavior of Collagen-Crosslinked Porcine Cornea // Ophthalmologica. — 2004. — V. 218. — P.136-140.

13. Wollensak G., Spoerl E., Seiler T. Riboflavin/Ultraviolet-A Induced Collagen– Crosslinking for the Treatment of Keratokonus // Am. J. Oftalmol. — 2003. — V. 135. — P.620-627.

14. Wollensak G., Wilsch M., Spoerl E., Seiler T. Collagen Fiber Diameter in the Rabbit Cornea after Collagen — Crosslinking by Riboflavin/UVA // J. Cornea. — 2004. — V. 23. — P.503-507.

About this article

Authors: Solodkova E.G., Boriskina L.N.

Year: 2013

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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