September 2015, № 9 (184)

Karmanova D.S. THE IMPACT OF LOW DOSES OF THE HERBICIDE 2,4-D ACID DICLORFENOXIACETIC ON THE SEVERITY OF OXIDATIVE STRESS IN ANIMALSThe relevance of this topic is not in doubt, because of the ability of low-dose pesticides when you receive to cause oxidative stress, which can be considered as one of the сentral mechanisms underlying the many toxicological effects. These effects will be exacerbated by diet with high caloric value, which is currently quite widespread. Soil herbicide 2,4-dichlorophenoxyacetic dimethylammonium acid salt (2,4-DA), transformed to the toxic metabolite, is able to activate lipid peroxidation (LPO), accompanied by violation of transport and receptor proteins of cell membranes, decreased activity of antioxidant systems. The observed increase in the concentration of malondialdehyde in the group with the joint use of 2,4-DA and fats. In the experimental groups decreased SOD in the serum approximately 40 %, of catalase at 15—45 % relative to the control group, with a more pronounced depression of catalase was observed in animals of the 3rd group (2,4-DA). Thus, the results suggest that prolonged intake of low doses of 2,4-DA is accompanied by oxidative stress, manifested by increased peroxidation products in the liver and serum, as well as changes in the activity of antioxidant enzymes. In conjunction with a high-energy diet these symptoms become more pronounced.Key words: pesticides, rats, lipoperoksidation, blood serum, heart, liver.

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About this article

Author: Karmanova D.S.

Year: 2015

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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