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March 2015, № 3 (178)



Shilin V.A., Safronov A.A., Kozhanova T.G. STIMULATION OF REPARATIVE OSTEOGENESIS IN PSEUDOARTHROSIS IN THE EXPERIMENT IN RATSPseudoarthrosis are observed in 16–40 % of cases of long bones fractures. This pathology is observed in young adults. Applied surgical techniques are characterized by a high percentage of failures. The using of hydroxyapatite-collagen complex "Litar" in the experiment on rats showed its high effectiveness in stimulation of reparative osteogenesis. Immunohistochemical method was developed to quantify the proliferative activity of osteoblasts in the experiment compared to the control group. The use of "Litar" increases the processes of osteogenesis. The mechanism is associated with increased activity of blasts cells and stimulation of angiogenesis.Key words: stimulation of osteogenesis, pseudoarthrosis, "LitAr", hydroxyapatite.

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Year: 2015


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