2011, № 12

Torshin V.I., Teplov A.Y. CHANGE MECHANISM OF CONTRACTILE FUNCTION OF STRIATED MUSCLE MOUSE IN VITRO BY PROTEIN SENSITIZATION. INVOLVEMENT OF ATPWe investigated the involvement of ATP in the mechanism of the effect of protein sensitization (PS) on contractile function and non-quantum secretion of acetylcholine in the area of end-plate (H-effect) of isolated skeletal muscles of leg (m.soleus and m. extensor digitorum longus (m.EDL)) and stripes m . diaphragma mouse. In m.soleus and m.diaphragma dynamics of the force vector of muscle contraction is correlated with changes in the H-effect in all the studied experimental models. However, the extent of these changes in sensitized animals is less pronounced. It has been suggested that ATP is a party change in the mechanisms of functional properties m.soleus and m.diaphragma in PS and reflects the development of resistance mechanisms in these muscles to external loads. The reasons for the changes in contraction force m.EDL PS not related to ATP-mediated excitation mechanism of the muscle.Key words: contractile properties, nonquantum secretion of acetylcholine, m.diaphragma, m.soleus, m.extensor digitorum longus, mouse, protein sensitization, ATP.

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About this article

Authors: Teplov A.Yu., Torshin V.I.

Year: 2011

Editor-in-chief

Sergey Aleksandrovich
MIROSHNIKOV

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