Volkova N.V., Iureva T.N.
RESEARCH OF CYTOKINES BALANCE IN PATIENTS AFTER FISTULIZING ANTIGLAUCOMATOUS SURGERY ^{[№ 12 ' 2015]}
Effect of fistulazing surgery in glaucoma is reduced in every third case in 1–3 years after the intervention. Prevention of inappropriate inflammatory reaction and an attempt to "control" the healing process allow to prolong the hypotensive effect and increase the effectiveness of these interventions. Understanding of the course of postoperative regenerative-reparative process and knowledge of the factors that determine the duration and sequence of its phases at both the local and systemic levels, these approaches do pathogenetically justified. The study of the lacrimal fluid by enzyme immunoassay with determination of the level of interleukin-8 (IL-8), interleukin-6 (IL-6), and isoforms of 121 and 165 of family of vascular endothelial growth factor VEGF-A. The patients (n = 42) with uncompensated glaucoma were examined. The control group included healthy subjects (n = 18). The dynamics of pro-inflammatory and pro-angiogenic cytokines in terms of the day before, on the 3^rd day and after 2 months after surgery was examined. The level of interleukin-8 was (656,8 ± 205,7) / (656,8 ± 205,7) / (175 ± 89,3) pg/ml. Interleukin-6 — (23,28 ± 9,03) / (47,7 ± 25) / (33,0 ± 92) pg/ml. Level of 121 and 165 isoforms of the VEGF family A — (703,8 ± 379,4) / (364,4 ± 150) / (590 ± 230,7) pg/ml (quantitative values are in the order of timeline). In the group of patients receiving prolonged scheme of anti-inflammatory therapy, with the inclusion Restasis ®, the final level of IOP was significantly lower (p < 0.05), as well as the number of patients with a successful outcome of the surgery. Dynamics of proinflammatory cytokines IL-8 and IL-6 indicates the initial changed local tissue reactivity and confirms the course of inflammatory response during for at least 2 months of the postoperative period. Dynamics of isoforms 121 and 165 of the VEGF family confirms long-term nature of processes of fibroplasy and vasculogenesis and justifies the possible inclusion of angiogenesis inhibitors in postoperative rehabilitation of patients. Determination of cytokine balance of lacrimal fluid justifies the schema of postoperative rehabilitation of patients after fistulizing antiglaucomatous surgery. The dynamics of pro-inflammatory IL-8 and IL-6 interleukins indicates the initial changes in local tissue reactivity and confirmed the inflammatory response during for at least 2 months of the postoperative period. Dynamics of isoforms 121 and 165 of the VEGF family confirms long-term nature of processes of fibroplasy and vasculogenesis and justifies the possible inclusion of angiogenesis inhibitors in postoperative rehabilitation of patients.

Savina J.N., Zhukova S.I., Shchuko A.G., Yureva T.N.
OPHTHALMOLOGICAL MANIFESTATIONS OF ESSENTIAL HYPERTENSION IN CHILDREN AND TEENAGERS (PRELIMINARY REPORT) ^{[№ 4 ' 2013]}
The patients of childhood and adolescence with essential hypertension without visual complaints were examined. Disturbances of regional hemodynamics in the orbit vessels, sensory perception and neuronal interactions in the absence of significant ocular symptoms of hypertensive angiopathy were identified.

Zlobina A.N., Malyshev V.V. Shchuko A.G.
LASER TREATMENT OF CHRONIC CENTRAL SEROUS CHORIORETINOPATHY ^{[№ 12 ' 2012]}
Transpupillar thermotherapy (TTT) reduces the height of the detachment of the retina pigment and neuroepithelium and improves visual acuity, and improves blood circulation in the posterior short ciliary arteries, thus being pathogenetically proved safe and effective treatment of chronic central serous chorioretinopathy.

Shchuko A.G., Chesheyko Ye.Yu., Yuryeva T.N.
CRITERIA FOR DIFFERENTIAL DIAGNOSTICS OF FUNCTIONAL ANGULAR BLOCK — LATENT STAGE OF CLOSED-ANGLE GLAUCOMA ^{[№ 12 ' 2012]}
90 patients with suspected angle-closed glaucoma were examined. Control group consisted of 22 healthy patients without glaucoma, and no serious injuries of eyeball structures. Structural and functional changes in the visual system, characteristic for functional angular block, were revealed. They are significantly different from that of patients with functional angular block. UBM criteria of iridociliary zone structure in patients with functional angular block were determined. Functional angular block is an independent pathological status of visual system and is a latent stage of angle-closed glaucoma.