Kartashova O.L., Pashkova T.M., Pashinina O.A.
INFLUENCE OF MEDICINAL PREPARATIONS OF PLANT ORIGIN ON ANTILIZOZYMIC ACTIVITY OF PRIORITY TYPES OF UROFLORA ALLOCATED FROM UROLITHIASIS PATIENTS ^{[№ 9 ' 2017]}
One of the most common urological diseases is urolithiasis, the therapy of which uses herbal medicines, effective in the presence of a disease associated with the inflammation in the urinary tract. A pathogenetically determined relationship between the presence of urinary stones and the occurrence of a chronic urinary infection is established in which the causative agent has a set of persistent properties that allow it to persist for a long time in the host organism. Phytopreparations have a different effect on the body, which is due to the biologically active substances that make up their composition. At the same time, the effect of herbal medicines on the persistent potential of microorganisms, in particular, antilysozyme activity, which is one of its significant factors, has not been studied.
In this connection, the effect of a number of phytopreparations, differing in composition and used for the treatment and prevention of urinary tract infections, on the antilysozyme activity of priority uroflora species isolated from patients with urolithiasis (P. aeruginosa and E. coli) was studied in vitro. The study of the possibility of phytopreparation regulation of the antilysozyme sign of bacteria in an in vitro experiment revealed their unidirectional inhibitory effect and found that the maximum reduction in antilysozyme activity in P. aeruginosa occurred under the action of the drug Gentos, and in E. coli — Kanefron.
Thus, the revealed ability of phytopreparations to unilaterally reduce the antilysozyme activity of Pseudomonas sp. and Escherichia sp. under in vitro conditions can be considered as one of the possible mechanisms of their biological activity in vivo.