Bokov D.A., Neverova P.S., Obidchenko M.P., Senchukova M.A., Shevluk N.N.
EXPERIMENTAL MODELING OFTOXIGENIC PATHOLOGYEMBRYOGENESIS: ENVIRONMENTAL ASPECTS ^{[№ 10 ' 2015]}
Using patented models of experimental gastric cancer on the subacute formaldehyde chronic intoxication background, it has been studied its effect on the laboratory rats' pregnancy and development of the embryo and fetus.The results reveal a disorder of the volume and direction of the histological and organ differentiation process that determines the subsequent animals' stillbirth. Particularly, histological examination has found that stillborn rats have fetal and even embryonic organs. Their lungs werein the saccular stage of development. Cuboidal epithelium of saccules was not changed on squamous one. Strom was presented by only cellular elements, its elastic fiber component wasn't expressed.Formation of adequate alveolar-vascular relations was delayed.These structural factors contribute to the inability to maintain an effective gas exchange.The kidneys of these animals were on the metanephrogenicblastema stage.The digestive tube was at the epithelial plug stage.In the skeleton there were no centers of ossification.The whole complex morphogenetic phenomena allows to prove unviability of newborn rats: a significant proportion of their stillbirths.At the same time, fertility, the possibility of pregnancy and its parameters are suppressed, that resulting in a decrease in weight and number of newborn rats. Long-term intake of subthreshold concentrations of formaldehyde, caused by the accumulation of the substance in hydro- and edafosfere, proves embriotoxic value of xenobiotic and poor prognosis of pregnancy and the end of gestation, considering carcinogenic effects and cancer of the mother's stomach.

Egorova I.N., Neverova O.A.
ASSESSMENT OF RADIONUCLIDE POLLUTION MEDICINAL RAW MATERIALS ACHILLEA MILLEFOLIUM L., UNDER CONDITIONS OF WASTE DUMP AT KEDROVSKY COAL MINE ASSESSMENT OF RADIONUCLIDE POLLUTION IN FRUIT ^{[№ 10 ' 2015]}
The article presents the estimation of radionuclide pollution of medicinal plant materials (herbs, flowers) Achillea millefolium L., growing on the waste dump of the Kedrovsky coal mine the Kemerovo region, and the estimation of complementary embryonic soils in matter of natural (K-40, Th-232, Ra-226) and artificial (Sr-90 and Cs-137) radionuclides. Analysis of the results showed no contamination of the embryonic soils dumps artificial radionuclides. The content of Sr-90 and Cs-137 is substantially below the regional average. The level of natural radionuclides is within the background levels of radioactive elements in the earth's crust. The analysis also revealed that the content of natural (K-40, Th-232, Ra-226) and artificial (Sr-90 and Cs-137) radionuclides in embryonic soils is higher than in medicinal plant material Achillea millefolium L.. the Main contribution to the radioactivity of raw materials gives K-40, it accounts for grass — 81 %, for flowers — 76 % of the total radioactivity. The proportion of artificial radionuclides Sr-90 and Cs-137 in grass and flowers of Achillea millefolium L. is in the range of 1.02...0.458 Bq/kg, not to exceed the allowable levels and do not present a hazard to the health of consumers according to SanPiN 2.3.2.1078-01. Analysis of rates of accumulation grass and flowers of Achillea millefolium L. radionuclides showed that they are more likely to accumulate anthropogenic radionuclide group Sr-90 and Cs-137. However, KN is less than one and are in the range of 0.56...0.41, which indicates the absence of data accumulation of radionuclides by plants. The obtained data will allow to assess the possibility of using medicinal plants growing on anthropogenically altered the Kemerovo region and get new resource sources and for harvesting of medicinal raw materials for the needs of the region.

Neverova N.N., Kikalova T.P., Smetanina M.D., Karpunina L.V.
INFLUENCE OF PAENIBACILLUS POLYMYXA LECTIN ON ACTIVITY OF GLUTATHIONE-S-TRANSFERASE IN BLOOD OF RATS AT STRESS ^{[№ 1 ' 2008]}
Influence of LII lectin defined from the surface of Paenibacillus polymyxa 1460 on activity of glutathione-S-transferase of blood erythrocytes of rats in conditions of short-time and long-time cold and immobilization stresses is studied in this article. It is shown that lectin influences favorably on animal’s organism leading enzymes activity to norm at different types of stress.

Neverov A.N., Tretyakov A.A., Stadnikov A.A.
MICROBIOLOGICAL AND MORPHOFUCTIONAL ASPECTS OF SPOROBACTERIN USING AT TREATMENT CORRECTION OF PUNGENT PLEURAL EMPYEMA ^{[№ 6 ' 2006]}
Original model of pungent pleural empyema is worked out in this article. Structural-functional reorganization of tissues forming residual cavity at different types of common and local treatment is studied here. It is established that sporobacterin creates better conditions for realization of adaptive and compensatory opportunities with parenchymatous and stromal elements of lungs and chest wall.