Musina L.A., Nuraeva A.B.
BURN WOUND HEALING WHEN USING ALLOGENIC BIOMATERIALS (EXPERIMENTAL STUDY) [№ 12 ' 2015]
Prevention of eyelid cicatricial deformity secondary to trauma or burn is the unmet need in ophthalmosurgery. In order to understand the mechanisms of tissue regeneration after eyelid surgical repair using allogenic biomaterials it is interesting to compare burn wound healing process without treatment, using conventional medications (Actovegin) and with the use of allogenic biomaterials in experiment. In the experiment was conducted on 84 white Wistar male-rats. Heat injury was modeled. In control group without treatment the healing process was accompanied by prolonged eschar presence, late epithelisation and slowdown of newly formed connective tissue maturation due to marked inflammation process. Reparation was incomplete and accompanied by coarse scarring. In the second control group treated with Actovegin the epithelisation was faster, nevertheless slowdown of reparation process in dermal layer was noticed. Inflammatory processes prevailed over reparative ones, granulation tissue stayed immature for a long time and eventually underwent scarring. In treatment group where animals underwent subcutaneous injection of disperse biomaterials (made from derma and tendon) rapid proliferation of epithelium was noted as long as necrotic mass demarcation and fast eschar desquamation. As granulation tissue matured it formed proper connective tissue plate of skin. It was found that the use of allogenic biomaterials in skin burns accelerated epithelisation and leaded to complete defect closure. Biomaterials inhibit coarse scarring during healing process.
Shangina O.R., Musina L.A.
ELASTIC-DEFORMATIVE PROPERTIES OF COMBINED ALLOGRAFTS FOR THE RESTORATION OF THE ORBITAL WALLS [№ 12 ' 2015]
The necessity of studying biomechanical properties of allografts stems from the inquiries of practical medicine. Problems of restoration surgery, transplantology and other sciences are solved based on the study of strength and deformative properties of tissues. The aim of physico-mechanical investigations is the evaluation of allograft as the material which temporary or constantly performs mechanical functions following the transplantation. Different methods of manufacture, preservation, lyophilization and sterilization of allografts lead, on frequent occasions, to the changes of biomechanical properties. The conservation of elastic-deformative properties of allografts during the process of their manufacture is an important factor which sets conditions for the effect of their clinical practice. Biomechanical tests were carried out in the tissue bank of the Russian Eye and Plastic Surgery Centre to evaluate strength properties of combined allografts manufactured according to Alloplant technology for the restoration of orbital walls. Combined allografts were modeled from the derma of the foot supporting areas and then were reinforced by the costal cartilage. The carried out tests showed the following results — the parameters of relative elongation, ultimate strength and Young's modulus of elasticity of derma allografts didn't subject to reliable changes (compared with the control group — native derma). It allows to make a conclusion that mechanical properties of the given allografts are preserved after the physico-chemical treatment. Ultimate strength and plastic deformation parameters of the allografts reinforced by the costal cartilage treated as per Alloplant technology didn't undergo considerable changes as well, compared with the control group (native derma). It is established that multistage physico-chemical treatment as per Alloplant technology does not have an adverse effect on the strength characteristics of the derma of the foot supporting areas and costal cartilage which are used to manufacture a combined allograft for the restoration of the orbital walls. Such strength properties of allografts as tension and deformation, which in their turn, are of the utmost significance play an important part in reconstructive surgeries.
Musina L.А., Khismatullina Z.R., Balkhiyeva L.Kh., Baygildin S.S., Vakhitova E.A.
CHARACTERISTIC PROPERTIES OF THE EYE RETINAL RADIAL GLIOCYTES OF EXPERIMENTAL RATS WITH PIGMENTED DEGENERATION [№ 12 ' 2014]
It was established that eye retinal radial gliocytes of WAG/Rij experimental rats with differences of genotype as per Tag 1A locus of DRD2 are characterized by destructive and proliferative changes accompanied by the expression of various degree of GFAP acidic glial fibrillar protein.
Shangina O.R., Musina L.А., Gaynutdinova R.D., Bulgakova L.A
EXPERIMENTAL AND MORPHOLOGICAL SUBSTANTIATION OF THE USE OF LASER RADIATION IN MODELING THE GRAFTS FOR OPHTHALMOSURGERY [№ 12 ' 2014]
There was carried out and experimental and morphological investigation of allografts for ophthalmosurgery modeled by laser radiation. It was established that modeling with laser cutting mode selection and peculiarities of the graft fibroarchitectonics taken into account allows to make the most of retaining their structure and it doesn't have a negative effect on the process of substitution and regeneration of tissues in grafting.
Musina L.A., Muslimov S.A., Kornilaeva G.G., Solovyeva E.P., Kornilaeva M.P.
THE MORPHOLOGY OF SPONGE ALLOGRAFT IN THE LONG-TERM PERIOD FOLLOWING THE ANTIGLAUCOMATOUS SURGERY [№ 4 ' 2013]
The enucleated eye balls of four patients who earlier underwent antiglaucomatous surgery using a sponge allograft have been investigated by histologic and electron-microscopic methods. It was revealed that in the long-term period (up to 8 years) following the surgery there had been detected the tissue on the place of the allograft similar to the eye trabecular meshwork structure maintaining drainage properties.
Muhsinova L.H., Musina G.R.
KEY AREAS OF INNOVATION IN OIL PRODUCTION UNDER RUSSIA'S ENTRY INTO WTO [№ 13 ' 2012]
In this paper the following issues are grounded: development of the national strategy for monitoring the activities of oil industry, strengthening of the state regulatory role in the field of enhanced oil recovery, creation of high-tech innovative oilfield service companies and oilfield engineering in partnership with the state.
Musina L.А., Balkhiyeva L.Kh., Khismatullina Z.R., Tabanakova Т.М.
THE EXPERIMENTAL MODEL OF THE EYE RETINAL PIGMENTAL DEGENERATION [№ 12 ' 2012]
The pigmental epithelial cell structure of WAG/Rij rat strain retina has been studied with histological and electron-microscope methods. A new potentially useful experimental model was recommended to develop the methods for the treatment of the eye retinal degenerative diseases.
Shcherbakov D.A., Nuraeva A.B., Musina L.M.
INFERIOR ORBIT WALL RECOVERY USING CHONDRAL ALLOGRAFTS [№ 12 ' 2012]
We have proved experimentally what the feasibility of chondral allografts for reimbursement of various defects of the inferior orbit wall. In the clinical part of the study we have developed indications for plate chondral allograft for fractures of the inferior orbital wall type blow-out with prolapse of orbital contents into the maxillary sinus and the combination of connective biomaterials to reconstruct small defects of the inferior orbital wall.
Bulatov R.T., Galimova V.U., Musina L.A., Rodionov O.V.
EXPERIMENTAL SCLEROPLASTY WITH TENDINOUS-FASCIAL ALLOGRAFT [№ 12 ' 2007]
Bulatov R.T., Galimova V.U., Rodionov O.V., Musina L.A.
MORPHOLOGICAL RESEARCHES ANALYSIS OF BIOPTIC MATERIAL FRAGMENTS OF DIFFERENT ALLOGRAFTS AFTER SCLEROPLASTY [№ 12 ' 2007]
Bulatov R.T., Galimova V.U., Rodionov O.V., Musina L.A.
EXPERIMENTAL SCLEROPLASTY WITH ALLOGRAFT OF TESTICLE ALBUGINEA [№ 12 ' 2007]
Volgareva E.A., Muslimov S.A., Musina L.A., Kornilaeva G.G.
ROLE OF MELANOCYTES IN CHOROIDS AT GLAUCOMA PATHOGENESIS [№ 12 ' 2007]
|Sergey Aleksandrovich |