Solodkova E.G., Ezhova E.A., Melikhova I.A.
SYSTEM OF AN OBJECTIVE ASSESSMENT THE GISTOMORFOLOGICHESKIKH OF CHANGES OF A CORNEA AFTER SURGICAL TREATMENT ^{[№ 12 ' 2015]}
To investigate and develop criteria for quantitative analysis histomorphological changes in the cornea after different types of effects on the cornea according confocal microscopy. The results of confocal microscopy at 274 patients (487 eyes) after different types of effects on the cornea — LASIK, PRK, corneal collagen crosslinking, and after contact lens orthokeratology lenses. We studied the morphological changes of the cornea, typical for these types of effects. The study developed a single 4-point system assessment of the general morphological changes of the cornea, allowing objectify assessment of all the structures of the cornea and the effectiveness of the treatment, as well as study the features of reparative and regenerative processes in the cornea. When orthokeratology correction observed thickening of stromal nerve fibers and the formation of so-called "acellular zone" in the follow-up of 1 month. After Lasik surgery microjets noted the presence of corneal flap, metallic inclusions in the interface, "fragments" of nerve fibers in the ablation zone. Change innervation to decrease the number of nerve fibers was noted by us and after the PRK and CBC in terms of supervision of up to 1 month. Start reinnervation after surgery occurred in a period of about 1 month. After corneal collagen cross-linking in the follow-up of 1 month or more in all cases observed the appearance of a linear opacities in the middle and back layers of the stroma.

Boriskina L.M., Solodkova H.G., Melikhova I.A.
MODIFICATION OF CORNEAL COLLAGEN CROSSLINKING IN TREATMENT OF PROGRESSIVE KERATOCONUS ^{[№ 12 ' 2014]}
There were studied treatment results in 61 patients with keratoconus of the I–II degree. I group comprised 25 patients (25 eyes), treated by conventional CXL method; II group included 36 persons (36 eyes) who had their surgery performed according to a modified technique. The latter has clinical efficiency and safety which are similar to the corresponding figures of the conventional method, but is distinguished by uncomplicated postsurgical period and a more pronounced positive dynamics in restoration of visual functions, which counts in its favor when choosing method of progressive keratectasia treatment.

Ezhova E.A., Melikhova I.A., Balalin S.V., Makovkin E.M.
CYTOMORPHOLOGICAL AND BIOMECHANICAL CHANGES IN CORNEA ASSOCIATED WITH APPLICATION OF ORTHOKERATOLOGICAL CONTACT LENSES IN MYOPIC CHILDREN AND ADOLESCENTS ^{[№ 12 ' 2014]}
Corneal status was assessed in 54 myopic patients (108 eyes) by means of confocal microscopy and rigidometry of corneoscleral membrane before and over the period of orthokeratological lens application. It was revealed that confocal microscopy enables evaluating cytomorphological changes in cornea, while rigidometry makes it possible to assess biomechanical after-effects of OCL wearing as well as their safety on a customized basis with regard to histomorphological state of corneal structures, findings of corneoscleral rigidity factor and level of intraocular pressure.

Solodkova E.G., Melikhova I.A.
CORNEAL COLLAGEN CROSSLINKING SAFETY EVALUATION IN TREATMENT OF PROGRESSIVE KERATOCONUS BASING ON REMOTE POSTOPERATIVE RESULTS ^{[№ 12 ' 2012]}
Safety and efficiency of two corneal collagen crosslinking (CXL) techniques was brought to comparative analysis. CXL was performed in 25 patients with progressive keratoconus: 9 patients (9 eyes) underwent a conventional CXL; 16 patients (16 eyes) had a modified CXL which novelty consisted of a depth-metered deepithelialization performed by excimer laser with on-line pachymetry Schwind Amaris (Germany). UV-A exposure was made by means of "UV-X" device (version 1000) (IROC Inc., Switzerland). All patients were prescribed to wear silicon-hydrogel soft contact lenses until a complete epithelial recovery. Improvement of NCVA, BCVA, topographic parameters, pachymetric values along with integrity of endothelial cell density was registered in all the cases which allows concluding that both CXL methods are safe and effective.

Shunkevitch O.N., MelikhovaI.A., BoriskinaL.N., BalalinS.V.
ROLE OF DESCEMETOGONIOPUNCTURE IN NORMALIZATION OF INTRAOCULAR PRESSURE IN CASES OF IOP ELEVATION IN THE EARLY POSTOPERATIVE PERIOD AFTER MICROINVASIVE NON-PENETRATING DEEP SCLERECTOMY ^{[№ 12 ' 2012]}
There were analyzed reasons, inducing elevation of intraocular pressure in 49 patients (49 eyes) with primary open-angle glaucoma in 1–3 months following microinvasive non-penetrating deep sclerectomy. A high thickness of trabecular Descemet membrane and presence of hypoechoic contents within the intrascleral space are the main factors leading to worsening of aqueous humor outflow and elevation of IOP in the early postoperative period. Normalization of IOP level basing on findings of ultrasound biometry was achieved in all the patients due to laser Descemetogoniopuncture.