Kunavina E.A., Dyusenov A.I., Zhdanova A.V., Kozminykh V.O.
HETEROCYCLIZATION OF THE ALKYL(ARYL)METHYLKETONES, DIETHYLOXALATE AND META-REPLACED AROMATIC AMINES IN THE SYNTHESIS OF QUINOLINE-2-CARBOXYLIC ACID ^{[№ 12 ' 2017]}
Rather large number of various medicinal preparations at which molecules there are heterocyclic systems of quinolone is known. Derivatives of a quinoline-2-carboxylic acid are potential biologically active materials, which have various biological activity. So, Atophanum (phenoquin) is received from acetophenone and an isatin by the Frindler method is applied as against arthritis means. Primachinum and plasmochin are the anti-malarial drug operating on gametes of a plasmodium of a malaria. Also some derivatives are applied as anesthetics or as drug against oncological diseases and as antibacterial medicament. Equimolar condensation of a ketone and dimethyl ester of oxalic acid received the intermediate diketoester. At addition to it the bases 7-hydroxy- and 7-amino-4-methylquinolines-2-carboxylic acids, 4-(4’-bromphenil)-7-hydroxy- and 7-amino-4-(4’-bromphenil)quinolines-2-carboxylic acids were received. In this article features of reaction depending on the nature of mother substances (alkyl- or arylmethylketones) and nucleophilic reagents (the meta-replaced arylamines), physical and chemical properties of the received connections are discussed. The structure of connections confirmed with data IR-spectroscopies, spectroscopies of nuclear magnetic resonance 1H and mass spectrometries. Proceeding from similarity of structures of the known biologically active materials of a quinolinic row and again synthesized representatives it is assumed that new substances will have potential biological activity and will find application in medical practice as medical drugs.

Zhirnikova Е.Yu., Kunavina E.A.
IR-SPECTROSCOPIC STUDY OF THE DRUG "DICLOFENAC" DIFFERENT MANUFACTURERS ^{[№ 10 ' 2015]}
This article provides an IR-spectroscopic characterization of popular on the pharmaceutical market drug "Diclofenac" in pill form three different manufacturers — "Ozon", "Hemofarm", Pharmaceutical company "Obolenskoe". The comparative analysis of infrared spectra. In all the samples based on the data of the IR spectra identified the main active ingredient of the medicinal product sodium salt of 2-[(2,6-dichlorophenyl)amino]-phenylacetic acid. In the experimental part presents the methodology of analysis of investigational product, lay down the conditions for recording infrared spectra. It is shown that the method of IR spectroscopy is applicable for the evaluation of authenticity of pharmaceutical drug "Diclofenac" and with a sufficient degree of accuracy can confirm the presence or absence of the medicinal product main active ingredient stated on the packaging.